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Yip (Zico) Tszho is the Chief Executive of Lonvi Biosciences, a longevity-drug start-up, in Shenzhen, China. They're developing pharmaceuticals for extending human lifespan. We discuss their first senolytic called PCC1.

Timestamps:00:00 Intro00:15 Articles about a pill making people live to 15002:50 What is PCC1 and how is it made07:10 How much can targeting senescence extend lifespan12:25 Bon Charge sponsorship13:15 Dose of PCC1 for senolytic and senomorphic effects18:30 PCC1 extending lifespan in mice by 9.4%23:20 Absorption rate of PCC1 and other senolytics27:10 Senolytics for young vs old age31:10 Human study on PCC134:40 What’s the optimal dose for senolytics38:05 Biomarkers of cell senescence40:10 Senolytic benefits on skin and retina46:35 What’s going on in Chinese longevity science52:10 Future direction of PCC1PCC1 studies: https://lonvibio.com/pages/science

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Brady Holmer is a science writer and researcher with a Master's degree in Human Performance from the University of Florida

Timestamps:00:00 Intro00:40 Why heat acclimation has performance benefits08:10 How to train heat acclimation12:40 Bon Charge sponsorship13:30 Benefits of the sauna for fitness18:25 Saunas and injury recovery22:30 Cold exposure and exercise performance26:45 Cooling down during and before exercise31:40 How often to train heat acclimation and sauna37:05 Sauna and HRV38:10 How long to stay in the sauna41:15 Electrolytes and dehydration acclimation46:25 Differences between men and women in heat acclimation47:00 Does heat acclimation have longevity benefits49:05 Does cold exposure have longevity benefits54:30 Which research should be done more on heat acclimation

First podcast with Brady about VO2 max: https://youtu.be/xLDaFhN6h8I

Brady Holmer Twitter: https://x.com/B_Holmer

Brady Holmer website: https://www.bradyholmer.com/Start rewinding your biological clock: https://www.siimland.co/course

Join our upcoming retreat in January 2026: https://www.siimland.co/retreat

Timestamps:Introduction (00:00)Discussion on longevity clinics and testing (01:52)Essential health tests and biomarkers (05:45)Improving VO2 Max and cardiovascular health (11:28)Blood tests and metabolic health (16:42)Hormone tests and longevity (21:35)Microbiome tests and toxicity (26:55)Microplastics and environmental toxicity (32:14)Food sensitivity testing (39:01)NAD testing and energy metabolism (41:50)Comprehensive health retreat (49:29)

Dr. Joy Kong Youtube channel: https://www.siimland.co/retreat

Dr. Mark Tarnopolsky is a Professor and Division Head of Neuromuscular and Neurometabolic Disorders in the Department of Pediatrics at McMaster University. He completed a PhD in Cell Biology and Metabolism in 2001.

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Timestamps:00:00 Intro00:25 What are mitochondria03:55 Mitochondria in aging and longevity06:00 Oxidative stress, inflammation, and longevity09:30 Antioxidants and benefits of exercise12:40 Bon Charge sponsorship13:30 Who should take antioxidants21:30 Mark’s antioxidant cocktail study24:30 Why is exercise the best thing for your mitochondria30:35 How endurance training shapes the mitochondria35:10 High intensity interval training36:50 Role of mitochondria in muscle loss42:00 Nutrition for mitochondrial health46:50 Supplements for mitochondrial health53:35 Stimulating mitophagy

Dr Mark Tarnopolsky research page: https://scholar.google.com/citations?user=4jhi_KkAAAAJ&hl=en

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Timestamps:00:00 Intro00:48 The genetics of a 117-year-old woman08:16 Resilience, immunity and longevity14:33 Muscle building genetics19:33 FOXO3 and stress resilience24:53 FOXO3 gene editing32:08 Can telomere lengthening be harmful to some individuals38:58 IGF-1 and growth hormone and longevity50:08 Genetically short sleepers54:38 What you should know about your longevity genes

First podcast with Tyler about genetics and supplements: https://youtu.be/9GLbTEYewUs

Tyler Panzner channel: https://www.youtube.com/@drtylerpanzner

Timestamps

0:00 – Introduction

4:12 – Humans adapt, and that changes the rules

9:58 – Diet diversity, sensitivities, and n of 1

16:51 – Assess first: biomarkers that predict disease risk

18:27 – Fixing sleep, movement, diet, environment

22:47 – Caution on rapamycin, metformin, methylene blue

25:54 – FOXO3 stem-cell study and what it means

37:15 – Mindset and willpower as real enhancers

41:44 – TMG, astaxanthin, melatonin, creatine

47:09 – VO2 max priorities and performance trade-offs

48:51 – Balancing fitness with joy and purpose

53:18 – Biomarkers mediate risk more than labels

1:01:00 – 2030–2040: what is realistic

1:04:02 – Immortality probabilities and living well now

Julian Issa video podcast: https://youtu.be/vV8yMVGLG6Y?si=XiLxOx0bSSM-xT-v

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Timestamps:

00:00 Does exercise increase inflammation

03:03 Melatonin megadosing research

04:23 NOVOS vs Blueprint VS DoNotAge

07:44 Hidden things that contribute to my health

12:14 Bon Charge sponsorship

13:05 How to improve night shift work

15:40 Supplements to take before the sauna

17:15 Does caffeine age the brain

19:34 Can you make up for lost sleep

20:40 Thoughts on Urolithin A

23:14 Doing too much for longevity

27:59 How to stop waking up at 3AM

30:57 How much sodium do I consume

33:20 Do sleep supplements blunt natural sleep

37:07 Inflammation in longevity

41:23 Importance of good relationship with food

Get my 2025 supplement guide: https://www.siimland.co/supplement-list-2025

Timestamps:00:00 Intro00:14 Taurine01:19 Apigenin01:55 Resveratrol03:20 Rapamycin04:55 Metformin06:11 Calcium AKG07:30 Melatonin08:16 SIRT609:05 NAC09:43 NMN, NR, Niacinamide11:10 Niacin13:58 Glycine15:16 Spermidine16:44 Omega-3s17:40 Creatine18:48 Pterostilbene19:19 Magnesium20:16 Vitamin K220:45 Sulforaphane21:34 Curcumin22:08 Methylated B vitamins22:33 Glutathione24:08 Lithium24:55 Lutein & Zeaxanthin25:30 Vitamin C26:29 Ergothioneine27:23 Methylene blue28:46 Multivitamin29:37 Aged garlic extract30:22 Astaxanthin31:06 TMG31:50 Ginger32:15 CoQ1032:53 PQQ33:24 Chondroitin33:45 MSM32:25 Glucosamine34:54 Conclusion

100 supplements ranked worst to best: https://youtu.be/W8DZbYyuDmA

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