Dr. Michael Snyder is a genomicist, professor, and former chair of genetics at Stanford University School of Medicine. He is the Director of the Center for Genomics and Personalized Medicine at Stanford University and a pioneer in precision medicine and multi-omic profiling.

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Timestamps:

00:00 Intro

00:26 Dr. Snyder’s paper that changes the way we look at aging

05:46 Why aging accelerates after 44 and 60

09:31 What’s good for young people might not be good for someone who’s old

12:10 Metabolic changes that happen during aging

15:57 How big of a role does genetics play in longevity

21:57 What’s going to extend lifespan more: genetic engineering or lifestyle interventions

27:37 What is Multi-omics

31:10 Continuous glucose monitoring

35:10 Different types of glucose spikers

38:40 HRV tracking

42:00 How collecting more data can predict your health risks

47:48 Is tracking health preemptively bad

52:25 What people should track about their health

57:00 How the retina reflect systemic health risks

59:45 Biological age clocks

Dr. Michael Snyder's lab website: https://med.stanford.edu/snyderlab/about.htmlStart rewinding your biological clock: https://www.siimland.co/course

Siim Land returns as the current leader of the Longevity World Cup, to break down supplements, biomarkers, VO2 max, inflammation, sleep, and the difference between building health versus simply maintaining it.

Watch on YouTube: https://www.youtube.com/watch?v=ogy7l0nka-Y

Dr. Alexis Ortega is board-certified in longevity, regenerative and aesthetic medicine. He has a clinic Ad Astra in Barcelona, Spain.

Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland

Timestamps:

00:00 Intro

00:55 How to counteract age-related loss of facial harmony aside from just wrinkles

12:30 Does growth hormone change the face

18:10 Bon Charge sponsorship

19:17 What's the minimum effective dose of at-home skincare — the three things that actually move the needle?

21:28 Retinoids

24:05 Skin barrier support

27:00 Effect of sun exposure on extrinsic skin aging

31:02 Best evidence-based sunscreen ingredients

34:34 List of best sunscreen ingredients

36:00 Worst sunscreen ingredients

37:45 Daily sunscreen vs using the UV index as a guide

39:43 Do people overuse skincare products

42:33 Castor oil, beef tallow and egg yolks for skin

49:08 Are natural sunscreens effective

49:59 If someone had unlimited money today, what are the most promising rejuvenation interventions actually available?

51:08 What diagnostics Alexis would do with an unlimited budget

54:30 Rejuvenation therapies Alexis would do

55:18 Alexis approach to peptides

56:00 Intravenous senolytics

56:20 NAD injections

57:14 What you can do now to practically extend lifespan

59:40 Intravenous exosomes

01:00:25 Therapeutic plasma exchange

01:03:06 Stem cell therapy

01:05:30 Gene therapies

01:07:48 What biomarkers matter most for predicting long-term health

Alexis Ortega MD Instagram: https://www.instagram.com/alexis_ortega_md/