New medications for obesity, such as semaglutide and tirzepatide, are highly effective but can be associated with adverse effects that reduce adherence. Obesity expert and author Robert Kushner, MD, joins JAMA Deputy Editor Mary McDermott, MD, to discuss a recent JAMA Insights article on managing adverse effects of obesity medications.

Related Content:

• Managing Adverse Effects of Incretin-Based Medications for Obesity

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JAMA Editors' Summary

A patent foramen ovale (PFO) is present in approximately 25% of all adults. Author David M. Kent, MD, MS, of Tufts Medical Center and JAMA Associate Editor David Simel, MD, MHS, discuss how to evaluate the likelihood that a PFO was causal in a patient with a cryptogenic ischemic stroke, and closure of a PFO to lower the incidence of recurrent strokes for affected patients.

Related Content:

• Patent Foramen Ovale and Stroke
• Patent Foramen Ovale and Dysarthria in a Man in His 60s
• Management of Patients With a Patent Foramen Ovale With History of Stroke or TIA
• Heterogeneity of Treatment Effects in an Analysis of Pooled Individual Patient Data From Randomized Trials of Device Closure of Patent Foramen Ovale After Stroke
• Transesophageal Echocardiogram Detecting a High-Risk Patent Foramen Ovale

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JAMA Editors' Summary

Approximately 200 000 people are hospitalized for diverticulitis each year in the US, and the incidence of diverticulitis is increasing, particularly among younger people. Author Anthony Charles, MD, MPH, of the University of Vermont and JAMA Deputy Editor Mary M. McDermott, MD, discuss current evidence regarding the epidemiology, diagnosis, and treatment of diverticulitis.

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• Diverticulitis
• Quality-of-Life and Recurrence Outcomes Following Laparoscopic Elective Sigmoid Resection vs Conservative Treatment Following Diverticulitis
• Racial and Ethnic Disparities in Locoregional Recurrence Among Patients With Hormone Receptor–Positive, Node-Negative Breast Cancer

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JAMA Editors' Summary

A recent Review discusses the epidemiology, risk factors, diagnosis, and treatment of ovarian cancer. William Cliby, MD, and John Weroha, MD, PhD, both from the Mayo Clinic in Rochester, Minnesota, discuss this and more with JAMA Associate Editor Margaret Wheeler, MD.

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• Ovarian Cancer
• Endometriosis Typology and Ovarian Cancer Risk
• Screening for Ovarian Cancer

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JAMA Editors' Summary

Early-onset gastrointestinal cancers, typically defined as occurring in patients younger than age 50, are increasing worldwide. A recent JAMA Review summarizes current data on early-onset colorectal, pancreatic, and esophagogastric cancers. Coauthor Kimmie Ng, MD, MPH, of Dana-Farber Cancer Institute joins JAMA Deputy Editor Kristin Walter, MD, MS to discuss.

Related Content:

• Early-Onset Gastrointestinal Cancers
• Screening for Helicobacter pylori to Prevent Gastric Cancer
• First-Line Sugemalimab Plus Chemotherapy for Advanced Gastric Cancer

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JAMA Editors' Summary

Approximately 40% of men older than 50 have urinary frequency or urgency that affects their quality of life. Author John T. Wei, MD, MS, of the University of Michigan Department of Urology and JAMA Deputy Editor Mary M. McDermott, MD, discuss diagnosis and management of these symptoms in older men.

Related Content:

• Lower Urinary Tract Symptoms in Men

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JAMA Editors' Summary

In the 25 years since its emergence in the US, West Nile virus has become the leading cause of domestic mosquito-borne disease. It causes approximately 1300 neuroinvasive disease cases and 130 deaths annually in the US. Coauthor Carolyn Gould, MD, of the CDC joins JAMA Senior Editor Karen Lasser, MD, to discuss the review on this topic published in JAMA.

Related Content:

• West Nile Virus
• What Is West Nile Virus Infection?

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JAMA Editors' Summary

Worldwide, 1 in 3 women and 1 in 5 men older than 50 years experience osteoporotic fractures in their lifetime. Author Suzanne N. Morin, MD, MSc, of McGill University and JAMA Deputy Editor Mary M. McDermott, MD, discuss the diagnosis and management of osteoporosis.

Related Content:

• Osteoporosis