Obesity affects more than 1 billion people worldwide and is recognized by the World Health Organization as a chronic, relapsing disease. WHO recently published a guideline in JAMA on the use and indications of GLP-1 therapies for the treatment of #obesity in adults. Francesca Celletti, MD, PhD, and Ezekiel Emanuel, MD, PhD, join JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss.

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• World Health Organization Guideline on the Use and Indications of Glucagon-Like Peptide-1 Therapies for the Treatment of Obesity in Adults

Head and neck cancer is the seventh most common cancer worldwide and is commonly associated with tobacco and alcohol use, or human papillomavirus (HPV) infection. Author Lara Dunn, MD, of Memorial Sloan Kettering Cancer Center joins JAMA Associate Editor Margaret Wheeler, MD, to discuss the epidemiology, risk factors, diagnosis, treatment, and prognosis of head and neck cancer.

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• Head and Neck Cancer

Allergic rhinitis affects about 1 in 6 US adults. A recent JAMA Insights summarizes evidence regarding the associations of climate change and air pollution with allergic rhinitis and sinusitis. The discussion includes prevention and management strategies. Coauthor Neelima Tummala, MD, joins JAMA Deputy Editor Mary McDermott, MD, to discuss.

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• Climate Change, Allergic Rhinitis, and Sinusitis