In I Am Legend, a plague has decimated the world, and those unfortunate enough to survive are transformed into blood-thirsty creatures of the night. Robert Neville is the last living man on earth. Everyone else has become a vampire, and they are all hungry for Neville's blood. By day, he stalks the sleeping undead, by night, he barricades himself in his home and prays for the dawn.

Leda, a middle-aged divorcee, is alone for the first time in years when her daughters leave home to live with their father. Her initial, unexpected sense of liberty turns to ferocious introspection following a seemingly trivial occurrence. Throughout the novel, Ferrante's language is as finely tuned and intense as ever, and she treats her theme with a fierce, candid tenacity.

Six days ago, astronaut Mark Watney became one of the first people to walk on Mars. Now, he's sure he'll be the first person to die there. After a dust storm nearly kills him and forces his crew to evacuate while thinking him dead, Mark finds himself stranded and completely alone with no way to even signal Earth that he’s alive - and even if he could get word out, his supplies would be gone long before a rescue could arrive. But Mark isn't ready to give up yet.

Six years after four family members died of arsenic poisoning, the three remaining Blackwoods—elder, agoraphobic sister Constance; wheelchair-bound Uncle Julian; and 18-year-old Mary Katherine, or, Merricat—live together in pleasant isolation. Merricat has developed an idiosyncratic system of rules and protective magic to guard the estate against intrusions from hostile villagers. But one day a stranger arrives—cousin Charles, with his eye on the Blackwood fortune.

Traumatized by the bombing of Dresden at the time he had been imprisoned, Pilgrim drifts through all events and history, sometimes deeply implicated, sometimes a witness. He is surrounded by Vonnegut's usual large cast of continuing characters (notably here the hack science fiction writer Kilgore Trout and the alien Tralfamadorians, who oversee his life and remind him constantly that there is no causation, no order, no motive to existence).