検索キーワード： 歴史・解説

The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity - by chewing, brewing, and snorting - some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the 5,000-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze Age medicine, a worm-killing birch fungus, knotted to his leggings.

He has been called the greatest surgeon of the 20th century. The son of Lebanese immigrants, Michael DeBakey rose from humble beginnings in a backwater Louisiana town to dominate the landscape of modern medicine. His contributions to our understanding and treatment of cardiovascular disease, in particular, were innumerable and epoch-making. DeBakey led a life of high drama, from the streets of Jazz Age New Orleans and the operating theaters of pre-war Europe, to the battlefields of World War II and the floodwaters of Hurricane Katrina.  

Based on extensive research into the business records of mountain entrepreneurs, country stores, and pharmaceutical companies, Ginseng Diggers: A History of Root and Herb Gathering in Appalachia is the first book to unearth the unique relationship between the Appalachian region and the global trade in medicinal plants. Historian Luke Manget expands our understanding of the gathering commons by exploring how and why Appalachia became the nation’s premier purveyor of botanical drugs in the late-nineteenth century.

Cystic fibrosis was once a mysterious disease that killed infants and children. Now it could be the key to healing millions with genetic diseases of every type - from Alzheimer's and Parkinson's to diabetes and sickle cell anemia. Told from the perspectives of the patients, families, physicians, scientists, and philanthropists fighting on the front lines, Breath from Salt is a remarkable story of unlikely scientific and medical firsts, of setbacks and successes, and of people who refused to give up hope....

Beginning with opium, the “joy plant,” which has been used for 10,000 years, Thomas Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.

Is it smart to skip your annual physical? Should you put your trust in medical research? Is "low T" an actual disease? This book will examine these questions and more you've always wondered about in a collection of 50 essays on the medicine. The Doctor Will See You Now is a quirky and eclectic collection of short essays that explore evolving patient-physician relationship and reporting on medicine; famous doctors and notorious patients; surprising hospital practices and the future of healthcare; medical research, ethics, drugs, and money; and the brave new world of neurology.

In Patient Zero, Richard A. McKay presents a carefully documented and sensitively written account of the life of Gaetan Dugas, a gay man whose skin cancer diagnosis in 1980 took on very different meanings as the HIV/AIDS epidemic developed - and who received widespread posthumous infamy when he was incorrectly identified as patient zero of the North American outbreak.

With poignant insight and humor, Frank Vertosick, Jr., MD, describes some of the greatest challenges of his career, including a six-week-old infant with a tumor in her brain, a young man struck down in his prime by paraplegia, and a minister with a .22-caliber bullet lodged in his skull. Told through intimate portraits of Vertosick's patients and unsparing-yet-fascinatingly detailed descriptions of surgical procedures, When the Air Hits Your Brain illuminates both the mysteries of the mind and the realities of the operating room.

Most stories of medical progress come with ready-made heroes. John Snow traced the origins of London's 1854 cholera outbreak to a water pump, leading to the birth of epidemiology. Florence Nightingale's contributions to the care of soldiers in the Crimean War transformed hospitals from crucibles of infection to sanctuaries of recuperation. Yet histories of individual innovators ignore many key sources of medical knowledge.

Mescaline, LSD, and psilocybin mushrooms. There’s been a lot of discussion in the medical world lately about the potential benefits of these and other drugs for certain medical conditions, such as anxiety and depression. As we consider the place of psychedelics in the future, we can draw insight and guidance from the history of how psychedelics have been described, sought after, applied, and prohibited over the centuries. Erika Dyck, professor of history at the University of Saskatchewan, introduces you to the world of hallucinogens.

When Thomas Edison began wiring New York City with a direct current electricity distribution system in the 1880s, he gave humankind the magic of electric light, heat, and power; in the process, though, he inadvertently opened a Pandora's Box of unimaginable illness and death. Dirty Electricity tells the story of Dr. Samuel Milham, the scientist who first alerted the world about the frightening link between occupational exposure to electromagnetic fields and human disease.

The extraordinary Siddhartha Mukherjee has written a biography of the gene as deft, brilliant, and illuminating as his extraordinarily successful biography of cancer. Weaving science, social history, and personal narrative to tell us the story of one of the most important conceptual breakthroughs of modern times, Mukherjee animates the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices.

A History of the World in Six Plagues shows that throughout history, outbreaks of disease have been exacerbated by and gone on to further expand the racial, economic, and sociopolitical divides we allow to fester in times of good health. Princeton-trained historian Edna Bonhomme’s examination of humanity’s disastrous treatment of pandemic disease takes us across place and time from Port-au-Prince to Tanzania, and from plantation-era America to our modern COVID-19-scarred world to unravel shocking truths about the patterns of discrimination in the face of disease.

Measles, once seemingly defeated, is resurgent around the globe. Why, at a time when biomedical science is so advanced, do parents turn away from vaccination, endangering their own children and the health of the wider population? Using a combination of patient narrative, historical analysis, and scientific research, Dr. Adam Ratner, pediatrician and infectious disease specialist, argues that the reawakening of measles and the subsequent coronavirus pandemic are bellwethers of forgotten knowledge—indicators of decaying trust in science and an underfunded public health infrastructure.

When Rachel Somerstein had an unplanned C-section with her first child, the experience was anything but the “routine” operation her doctor described. A series of errors by her clinicians led to a real-life nightmare: surgery without anesthesia. The ensuing mental and physical complications left her traumatized and desperate for answers about how things could have gone so wrong. In the United States, one in three babies is born via C-section, a rate that has grown exponentially over the past fifty years.

Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor Southern tobacco farmer who worked the same land as her slave ancestors, yet her cells - taken without her knowledge - became one of the most important tools in medicine: The first “immortal” human cells grown in culture, which are still alive today, though she has been dead for more than 60 years. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects.

Between August 1918 and March 1919, the Spanish influenza spread worldwide, claiming over 25 million lives. In this vivid narrative, Alfred W. Crosby recounts the course of the pandemic during the panic-stricken months of 1918 and 1919, measures its impact on American society, and probes the curious loss of national memory of this cataclysmic event. This edition includes a preface discussing the then-recent outbreaks of diseases, including the Asian flu and the SARS epidemic. 

Since early 2020, the world has experienced a series of catastrophic events - a global pandemic caused by a so-called novel coronavirus; international lockdowns and border closings causing widespread business closures, economic collapse, and massive unemployment; and an unprecedented curtailment of civil liberties and freedoms in the name of keeping people safe by locking them up in their homes.

John C. Kendrew (1917-1997) was a pioneer in structural biology and a catalyst for the emergence of molecular biology in the second half of the 20th century. He was the first person to determine the three-dimensional structure of a protein at atomic resolution and, for this, was awarded the Nobel Prize in Chemistry in 1962. Kendrew ultimately became an international organizer, administrator, and advocate for science, and his expansive legacy lives on today.  

Plagues upon the Earth is a monumental history of humans and their germs. Weaving together a grand narrative of global history with insights from cutting-edge genetics, Kyle Harper explains why humanity’s uniquely dangerous disease pool is rooted deep in our evolutionary past, and why its growth is accelerated by technological progress. He shows that the story of disease is entangled with the history of slavery, colonialism, and capitalism, and reveals the enduring effects of historical plagues all around us, in patterns of wealth, health, power, and inequality.