Peptides are everywhere—but so are questions about safety, quality, access, and regulation.

In this episode of The Synergee Podcast, Kelly and Lori welcome back Jim LaValle for an inside look at the recent FDA advisory committee discussions surrounding peptides and what they could mean for the future of peptide therapy.

Jim shares what has changed since 2023, why gray-market and research-grade peptides are such a concern, and why provider oversight, quality, and monitoring matter.

They also discuss promising uses for peptides in areas like mitochondrial health, recovery, gut health, chronic pain, muscle preservation, and healthy aging.

Plus, Jim shares his own approach to longevity—and why movement, nutrition, sleep, recovery, and lifestyle still come before peptides.

A must-listen for anyone curious about where peptide therapy is headed and how to approach it safely and responsibly.

What if just 15 minutes of exercise could help your body use oxygen more efficiently and support better energy, recovery, and healthy aging?

In this episode of the Synergee Podcast, Lori and Kelly sit down with Brad Pitzele, founder of One Thousand Roads, to explore Exercise With Oxygen Therapy (EWOT)—a modality that combines light-to-moderate exercise with breathing high-concentration oxygen to enhance oxygen delivery throughout the body.

Brad shares his personal journey through autoimmune arthritis, chronic pain, Lyme disease, and melanoma, and explains how EWOT became an important part of his healing. Together, they discuss how oxygen, microcirculation, and mitochondrial health are connected, why VO₂ max matters for longevity, and how EWOT may support exercise recovery, energy production, circulation, and healthy aging.

Whether you're looking to improve athletic performance, recover from chronic illness, or better understand the science of oxygen and resilience, this episode offers an insightful look at an emerging wellness therapy.

Special Listener Offer

Check us out on YouTube

Learn more about EWOT

Learn more about Red Light Therapy

If you're eating well, exercising, and doing "all the right things" but still struggling with fatigue, stubborn weight, poor sleep, brain fog, or mood changes, cortisol may be part of the missing piece.

In this episode of the Synergee Podcast, Lori Esarey and Kelly Engelman sit down with endocrinologist Dr. Jay to explore the powerful connection between cortisol and blood sugar.

They discuss how chronic stress can raise glucose, contribute to insulin resistance, disrupt sleep and hormones, and affect metabolic health. You'll also learn what continuous glucose monitors can reveal, why blood sugar variability matters, how menopause and GLP-1 medications fit into the conversation, and why lasting change requires looking beyond food alone.

This episode will change the way you think about stress, blood sugar, and your body.

GLP-1 medications have become one of the biggest conversations in health and weight loss — but are they good, bad, or simply misunderstood?

In this episode, Kelly and Lori have an honest, balanced conversation about GLP-1s, metabolic health, blood sugar, muscle loss, nutrient depletion, hormone changes, gut health, and why these medications should never be treated as a quick fix. They discuss why GLP-1s may be helpful for the right person, at the right time, in the right amount — but only when paired with the foundations of health, proper testing, body composition tracking, and qualified clinical guidance.

You'll hear what GLP-1s actually do in the body, why food noise changes, how muscle loss and nutrient deficiencies can become real concerns, what labs should be considered before starting, and natural ways to support your body's own GLP-1 production through fiber, protein, blood sugar balance, probiotics, movement, sleep, and gut health.

This episode is a must-listen for anyone considering GLP-1s, currently using them, worried about a loved one, or wondering how to approach weight loss without sacrificing long-term health, energy, strength, and vitality.

What if aging isn't simply the passage of time—but the result of inflammation, cellular breakdown, and lost communication within the body?

In this fascinating conversation, Kelly and Lori sit down with stem cell biologist Dr. Ian White to explore a completely different way of thinking about aging. Together, they dive into the emerging science of regeneration, stem cells, cellular communication, inflammation, fasting, nutrition, environmental toxins, and the everyday choices that may influence how we age.

Dr. White challenges the belief that decline is an inevitable part of getting older and shares why biological age may matter far more than chronological age. You'll discover practical strategies for supporting the body's natural repair mechanisms, reducing inflammation, and creating an environment where healing and resilience can thrive.

If you've ever wondered whether you have more control over aging than you've been told, this episode will leave you inspired, empowered, and looking at your health through an entirely new lens.

In this episode you'll learn:

• Why aging may be driven by breakdown rather than time
• The role of stem cells in repair and regeneration
• How inflammation accelerates biological aging
• Why food, fasting, and nutrient status matter
• The connection between cellular communication and longevity
• Emerging therapies shaping the future of regenerative medicine
• Simple ways to support your body's natural healing potential

What if your fatigue isn't just about getting older… or being busy?

In this powerful episode, Dr. Sam Shay returns to The Synergee Podcast to uncover the deeper root causes behind low energy, brain fog, burnout, hormone shifts, poor recovery, inflammation, and feeling like your body just isn't functioning the way it used to.

This conversation goes far beyond "just being tired." We dive into the hidden physiology behind mitochondrial dysfunction, toxic burden, mineral depletion, viral load, mold exposure, hormone imbalance, and chronic stress — and how all of these can impact energy production at the cellular level.

In this episode, we discuss:
• Why your mitochondria may not be producing energy efficiently
• The connection between heavy metals, toxins, and low energy
• How stress and inflammation deplete minerals and impact recovery
• The hidden role viruses like Epstein-Barr may play in chronic fatigue
• Mold exposure, brain fog, and the "hijacked brain" feeling
• Why over-exercising and pushing harder can backfire
• The truth about testosterone clinics and incomplete hormone testing
• Why men deserve a deeper functional medicine workup
• How gut health and detox pathways affect healing and energy
• The mindset shifts needed to rebuild resilience from the inside out

If you've been doing "all the right things" but still feel exhausted, foggy, unmotivated, or stuck in survival mode, this episode will help you understand why — and what deeper healing may actually look like.

What if the foods most people consider "healthy" aren't actually giving the body what it truly needs?

In this eye-opening episode, we sit down with a professional chef turned health advocate to discuss the difference between simply eating "real food" and eating foods that are truly nutrient-dense and bioavailable. After a frightening health crisis involving his young daughter, his entire perspective on nutrition changed — leading him down the path of ancestral nutrition, organ meats, and understanding how the body naturally communicates what it needs.

In this conversation, we discuss:
• Why flavor and the palate matter more than most people realize
• The hidden problem with modern processed foods and "health marketing"
• Why healing has to be both easy and delicious to become sustainable
• How stress, toxins, and inflammation disconnect us from our body's signals
• The concept of "like supports like" when it comes to organ meats
• Practical ways to introduce nutrient-dense foods into everyday meals
• Why mindset and belief play a major role in healing
• The importance of slowing down, eating mindfully, and reconnecting with the body

This episode is packed with practical nutrition insights, ancestral wisdom, and a refreshing perspective on how to nourish the body in today's modern world.

Click here to purchase Pluck and use code SYNERGEE at checkout for 15% off your entire order.

What if your constant cravings… your "food noise"… and your struggle with willpower weren't actually your fault?

In this episode of the Synergee Podcast, we sit down with Sarah Kennedy, CEO of Calocurb, to unpack the real science behind hunger, appetite, and metabolic health.

This is not another "eat less, try harder" conversation.

We dive into:

• Why your brain is wired to think about food (and how evolution plays a role)
• The truth about GLP-1, appetite hormones, and hunger signaling
• The difference between true hunger vs. food noise
• Why restrictive dieting actually makes cravings worse over time
• How gut health and bitter taste receptors influence appetite control
• The key difference between natural appetite support and synthetic GLP-1 medications
• What women in perimenopause and beyond need to understand about metabolism shifts

If you've ever felt stuck in the cycle of restrict → crave → overeat → repeat, this episode will feel like a breath of fresh air.

Because the goal isn't more discipline…
It's restoring calm, clarity, and confidence in your body.

This conversation will challenge what you've been taught about hunger—and give you a more grounded, science-backed path forward.

🎧 Tune in and discover what it actually feels like to experience freedom from food noise.