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Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. John Fralick. This week, he discusses a recently published trial exploring the effects of add-on sotatercept in patients with advanced pulmonary arterial hypertension and a high risk of death. Here we go!

1. Sotatercept in Patients with Pulmonary Arterial Hypertension at High Risk for Death (0:00 – 5:38).

The Good Stuff:

• 2025 Scripps National Spelling Bee winning word: éclaircissement (5:39 - 6:34)

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back today with a special Rapid Fire Podcast. This week, Dr. Mike Fralick and guest host Danielle Cutler discuss the top papers from the 2025 American Diabetes Association (ADA) Scientific Session. Hot off the presses, here we go!

1. Once-Monthly Maridebart Cafraglutide for the Treatment of Obesity — A Phase 2 Trial (0:00 - 6:05)
2. Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (6:06 - 13:22)
3. Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes (13:23 - 20:35)

The Good Stuff:

• Diabetes Trial Files - Free monthly newsletter! Subscribe at https://diabetestrialfiles.substack.com/ (20:36 - 21:00)
• Congrats to Danielle and all the med students finishing their academic year! (21:01 - 21:57)

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! Today we have the next episode in our Clinical Practice Guidelines series. Drs. Mike and John Fralick discuss the top takeaways from the 2024 KDIGO Clinical Practice Guidelines for chronic kidney disease. Here we go!

1. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease (0:00 - 24:24)

Access the KDIGO 2024 "Top 10 Takeaways" PDFs here: https://kdigo.org/guidelines/ckd-evaluation-and-management/

The Good Stuff:

• Nephrology Trial Files - https://nephrotrialfiles.substack.com/ (24:25 - 24:48)
• The Phoenician Scheme (24:49 - 25:33)

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! Today we have another special episode— Trial Files turns two years old this June, and we're celebrating with an episode summarizing the Top 5 RCTs in the Trial Files catalogue to date. Dr. Mike Fralick takes us through five trials in 15 minutes. Here we go!

1. Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes (0:00 - 3:08)

2. Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia (3:09 - 5:37)

3. Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis (5:38 - 8:33)

4. Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections (8:34 - 11:22)

5. Finerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction (11:23 - 13:23)

Happy 2nd Birthday, Trial Files!

• A free monthly newsletter on practice-changing trials, delivered straight to your inbox-- sign up at https://trialfiles.substack.com/ (13:24 - 14:19)

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! Today we're introducing a new format—the first episode in our Trial Files series, where we provide an overview of a recent Trial Files issue. This week, Dr. Mike Fralick discusses three trials included in a recent throwback issue: opioids versus non-opioids for chronic pain; IV albumin for renal impairment and mortality; and omeprazole before endoscopy in patients with GI bleed. Three trials, 9 minutes, here we go!

1. Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain: The SPACE Trial (00:00 - 2:46)

2. Effect of Intravenous Albumin on Renal Impairment and Mortality in Patients with Cirrhosis and Spontaneous Bacterial Peritonitis (2:47 - 4:50)

3. Omeprazole before Endoscopy in Patients with Gastrointestinal Bleeding (4:51 - 7:39)

What is Trial Files?

• A free monthly newsletter on practice-changing trials, delivered straight to your inbox-- sign up here! (7:40 - 8:40)

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! Today we have a solo episode with Dr. Mike Fralick. This week, he discusses a recently published head-to-head trial exploring the safety and efficacy of tirzepatide compared to semaglutide for obesity management. Here we go!

1. Tirzepatide as Compared with Semaglutide for the Treatment of Obesity (0:00 – 7:07).

The Good Stuff:

• Trial Files, a free monthly newsletter on practice-changing trials, delivered straight to your inbox. (7:08 - 7:53)

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back Rounds Table Listeners! We are back this week with a special podcast episode. Dr. Mike Fralick sits down with Dr. David Juurlink, pharmacologist and internist, Professor of Medicine at the University of Toronto, and head of the Clinical Pharmacology and Toxicology division at Sunnybrook Health Sciences Centre, to chat about the top drug interactions you might be missing. Here we go!

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

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Welcome back, Rounds Table Listeners! This week we have a solo episode with Dr. John Fralick, discussing a recently published trial of the GLP-1 receptor agonist semaglutide for the treatment of metabolic dysfunction–associated steatohepatitis (MASH). Here we go!

1. Phase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis (0:00 – 6:33).

The Good Stuff:

• Go Leafs go!

Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods