Welcome to The Pet Longevity Lab, where science meets pet wellness. In this episode, we explore the fascinating interplay of osteoclasts, osteoblasts, testosterone, and osteocalcin in bone health. Dive deep into the biology of bone remodeling, the crucial role of hormones in maintaining skeletal integrity, and how disruptions can lead to significant health challenges for both humans and pets.

We’ll uncover how testosterone stimulates bone-building cells while inhibiting bone-resorbing cells, and examine osteocalcin as a powerful marker of bone formation and its surprising connection to metabolic health. Whether you’re a pet owner, veterinary professional, or science enthusiast, this episode provides an engaging look at the critical role of hormones in shaping health and longevity.

Special thanks to researchers and veterinarians advancing this field, and join us to discover how hormonal insights are paving the way for better care and longer lives for our furry companions. Don't miss this enlightening journey into the science of bone health!

In this episode, we explore the surprising and powerful link between testosterone and inflammation—and why this matters not just for humans, but for our pets too.

Drawing from peer-reviewed human studies by Mohamad et al. and Bianchi, we break down how testosterone influences pro-inflammatory cytokines, impacts adipose tissue, and plays a key role in chronic disease prevention. You’ll learn how low testosterone levels are associated with systemic inflammation and how hormone therapy in men has shown promising results in reducing markers like IL-6, TNF-α, and CRP.

So why are we talking about this on a pet health podcast?

Because pets—especially those that are spayed or neutered—also suffer from hormone deficiency and many of the same inflammation-driven conditions: arthritis, cognitive decline, obesity, and more. This episode lays the foundation for understanding how research in human endocrinology can guide integrative, evidence-based approaches to extending pet healthspan.

🔬 Key Topics Covered:

• Testosterone’s role in immune modulation

• The connection between fat tissue, inflammation, and hormone loss

• What the human data tells us about restoring balance in neutered/spayed pets

• Why this research is central to Pet Longevity Lab’s hormone-first philosophy

🎧 If you care about science-backed pet wellness, aging, and inflammation—this episode is a must-listen.

👉 Learn more at 1mpet.org

In this episode of The Pet Longevity Lab Podcast, we explore the latest research linking testosterone, osteoarthritis, and joint health in both women and companion dogs. A recent study suggests higher testosterone levels may protect women from knee OA, while another large-scale study in dogs identifies neutering and weight gain as major OA risk factors—raising critical questions about the role of sex hormones in joint health.

Join us as we break down the science, risks, and practical takeaways for both human and veterinary medicine. Could hormone balance be the key to longevity and mobility? Tune in to find out!

In this episode of The Pet Longevity Lab Podcast, we take a closer look at Librela (bedinvetmab), the FDA-approved monoclonal antibody for canine osteoarthritis pain management. While Librela is marketed as a breakthrough in pain relief, recent reports—including an FDA Dear Veterinarian Letter—raise serious concerns about its safety, long-term effects, and potential risks of accelerated disease progression.

We explore the mechanism behind Librela’s NGF blockade, why blocking pain without addressing joint degeneration may lead to unnoticed microtrauma and worsening osteoarthritis, and the FDA-reported adverse events such as ataxia, seizures, paresis, and even euthanasia cases.

Plus, we discuss alternative approaches, including Testosterone Replacement Therapy (TRT) and Adequan (PSGAGs), which offer joint support, metabolic benefits, and regenerative potential rather than just masking symptoms.

Tune in as we break down the science, the risks, and the best approaches for keeping senior dogs active, healthy, and truly supported in their osteoarthritis care. Is Librela really the best solution, or are there better, safer alternatives? Listen in to find out!

In this episode of The Pet Longevity Lab Podcast, we break down the debate between Loyal’s experimental IGF-1 modulating drugs and Testosterone Replacement Therapy (TRT) for senior dog health and longevity. Loyal is developing drugs to manipulate IGF-1 levels in older dogs, but with potential safety concerns, high costs, and a long road to FDA approval, are they the best option?

We explore why TRT is a superior, immediately available, and cost-effective alternative that naturally regulates IGF-1 levels while offering broader health benefits, including improved metabolism, muscle strength, joint support, and cognitive function.

Join us as we discuss the scientific evidence, cost comparisons, and real-world implications of both approaches—helping pet owners and veterinarians make informed decisions about what’s best for canine longevity today, not a decade from now.

In this episode of The Pet Longevity Lab Podcast, we dive deep into the latest research on the effects of spaying and neutering (gonadectomy) on dogs. Conventional wisdom tells us that neutering is the best option for every pet, but new studies challenge this one-size-fits-all approach. We discuss the increased risks of immune disorders, joint problems, and cancers, highlighting how breed, sex, and timing play crucial roles.

We also explore alternative sterilization options and the emerging field of hormone restoration therapy, which is showing promising results in improving mobility, muscle mass, and overall well-being in neutered dogs. Whether you’re a pet parent or a veterinarian, this episode provides critical insights to help you make informed decisions about your dog’s health.

For more information please visit 1mpet.org

In this episode of The Pet Longevity Lab, we explore the groundbreaking research featured in "Rottweiler Study Links Ovaries with Exceptional Longevity" by Dr. David J. Waters and his team. This pivotal study sheds light on the fascinating relationship between ovarian preservation and extended lifespan in female Rottweilers, a discovery with profound implications for both veterinary and human health.

Join us as we discuss how retaining ovaries beyond six years of age significantly increases the likelihood of reaching exceptional longevity, a pattern mirrored in human studies on ovarian health. We’ll dive into the science behind the findings, including the hormonal and biological mechanisms that influence aging, and consider what this means for spay/neuter protocols.

Through this deep dive, we’ll challenge conventional wisdom and explore how individualized approaches to sterilization could revolutionize pet wellness. Special thanks to Dr. Waters and the Gerald P. Murphy Cancer Foundation for advancing our understanding of longevity and aging in both pets and people.

Tune in to uncover how preserving hormonal balance could be the key to a longer, healthier life for our furry companions!

In this episode of The Pet Longevity Lab, we dive into the seminal study, "Endogenous Gonadal Hormone Exposure and Bone Sarcoma Risk", authored by Dr. Dawn M. Cooley and her team from Purdue University. This pivotal research investigates the link between lifetime exposure to gonadal hormones and the risk of bone sarcoma in Rottweilers, a breed predisposed to this aggressive cancer.

We’ll explore how early gonadectomy significantly increases the lifetime risk of bone sarcoma and discuss the protective role of sex hormones in skeletal health. This study’s findings highlight the intricate connection between hormonal balance and cancer risk, providing insights into both canine and human health. We'll also examine the broader implications for pet owners and veterinarians, as well as how these results could shape future preventative strategies for osteosarcoma.

Special thanks to the authors for shedding light on the critical importance of preserving hormonal balance in pets. Join us as we unpack the science, implications, and actionable takeaways for improving pet care and wellness. Don’t miss this eye-opening episode!