エピソード

  • Conservation Genetics at the San Diego Zoo Wildlife Alliance | Marisa Korody, PhD

    Conservation Genetics at the San Diego Zoo Wildlife Alliance | Marisa Korody, PhD
    2025/12/17
    Marisa Korody, PhD, serves San Diego Zoo Wildlife Alliance as a scientist in conservation genetics, working on the northern white rhino rescue project. She works closely with collaborators at The Scripps Research Institute to optimize the production of induced pluripotent stem cells (iPSCs) from banked rhino fibroblast cells in the Frozen Zoo® for potential use in assisted reproductive technologies. This episode was recorded on Aug. 13, 2025, and information is current as of the date of recording. Hosted by Bobby Gordon.
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    30 分
  • The Evolution of DNA Editing and Stem Cells | Alexis Komor, PhD

    The Evolution of DNA Editing and Stem Cells | Alexis Komor, PhD
    2025/12/04
    This episode features our conversation with Alexis Komor, PhD, who serves as deputy director of the Sanford Stem Cell Innovation Center and assistant professor in the Department of Chemistry and Biochemistry at UC San Diego. Not long after the discovery of CRISPR technology, Komor Identified how to edit DNA in a new, more precise way, down to a single base unit in the DNA sequence. Komor's contributions in teaching, mentoring, and research have been recognized with many awards, including the Cottrell Scholar Award, the "Talented 12" recognition by C&EN News, an NSF Faculty Early Career Development (CAREER) award, a U.S. National Institutes of Health early stage investigator Maximizing Investigators' Research Award (MIRA), and a "40 under 40" recognition in healthcare by Fortune magazine. Hosted by Bobby Gordon. This episode was recorded on July 7, 2025, and information presented is accurate as of this date.
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    38 分
  • Dan Kaufman, MD, PhD | Manufacturing Stem Cell-Based Therapies at UC San Diego

    Dan Kaufman, MD, PhD | Manufacturing Stem Cell-Based Therapies at UC San Diego
    2025/11/14
    This episode features a conversation Dan Kaufman, PhD, Director of the Sanford Advanced Therapy Center at the Sanford Stem Cell Institute, and his extensive background in the field of regenerative medicine. At UC San Diego, Dr. Kaufman performs clinical work in hematology and blood and marrow transplantation. He also oversees the Advanced Cell Therapy Laboratory (ACTL), a cGLP/cGMP-compliant facility which provides good manufacturing practice and cell manufacturing to translate new cell-based therapies to clinical trials; to help investigators advance cell therapy products from research to clinical manufacturing. Hosted by Bobby Gordon. This episode was recorded on Aug. 14, 2025, and information was current as of the date of recording.
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    31 分
  • Alex Khalessi, MD, MBA | Stem Cell Therapy and Neurological Disorders

    Alex Khalessi, MD, MBA | Stem Cell Therapy and Neurological Disorders
    2025/10/22
    Our discussion in this episode features Alex Khalessi, MD, MBA, and his innovative work on the intersection between stem cell therapies, regenerative medicine, and neurological disorders. He serves as co-director of the Brain Tumor and Neurorestoration Program at the Sanford Stem Cell Institute. Khalessi is the former president of the Congress of Neurological Surgeons (CNS), and is chair of the Department of Neurological Surgery, professor of neurological surgery, radiology and neurosciences and the inaugural Don and Karen Cohn Chancellor's Endowed Chair in Neurosurgery at UC San Diego. As a board-certified neurosurgeon, he specializes in complex cranial surgery, endovascular neurosurgery, stroke care, and neurological oncology. Hosted by Bobby Gordon. This episode was recorded Aug. 15, 2025; information presented was current as of the date of recording.
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    43 分
  • Pinar Mesci, PhD | Innovative Stem Cell Research in Space

    Pinar Mesci, PhD | Innovative Stem Cell Research in Space
    2025/09/30
    This episode is a robust conversation with Pinar Mesci, PhD, the Senior Program Manager for In-Space Manufacturing at Axiom Space. Our discussion includes her postdoctoral work with Alysson Muotri, PhD, at UC San Diego and her ongoing work leading and facilitating space-based research in low-Earth orbit. Previously, Dr. Mesci was a project scientist at UC San Diego studying human neurodevelopment using human induced pluripotent stem cells (iPSCs). Her career includes experience in translational and biomedical research with a track record of publications in the fields of neuroscience, stem cells, inflammation, Zika virus and coronavirus infections. Dr. Mesci holds a patent for the development of methods to generate functional human brain organoids. In 2021, she received the International Rett Syndrome Foundation (IRSF) Innovation Award for her work studying the immune interactions in Rett Syndrome using iPSCs. Hosted by Bobby Gordon. This episode was recorded Aug. 8, 2025; information presented was current as of the date of recording.
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    32 分
  • Joel Castellanos, MD | Stem Cells and Spinal Cord Injuries

    Joel Castellanos, MD | Stem Cells and Spinal Cord Injuries
    2025/09/09
    The Sanford Stem Cell Institute's Bobby Gordon sits down with Joel Castellanos, MD, one of UC San Diego's premiere spinal cord injury researchers and practitioners. He serves as one of the Alpha Clinic's Trial Experts, and as the associate clinical professor of anesthesiology at UC San Diego School of Medicine. Our discussion includes his ideas and work formulating and building a foundational infrastructure across disciplines to treat and rehabilitate spinal cord injuries and function. He is a board-certified physical medicine and rehabilitation and pain medicine physician, and serves as medical director of Inpatient Rehabilitation. Dr. Castellanos' prime focus is improving function using an individualized approach. His expertise with interventional pain techniques allows for an integrative strategy to preserve and restore function. Dr. Castellanos evaluates, diagnoses and treats all forms of functional disability and pain using a multi-disciplinary team-based approach. He is particularly interested in neuromodulation at various levels including spinal cord stimulation and peripheral nerve stimulation, interventional spine procedures, radiofrequency neurotomy, ultrasound-guided and fluoroscopically-guided procedures, and regenerative medicine such as platelet-rich plasma, stem cells, and Tenex (minimally invasive technology for treatment of chronic pain). Hosted by Bobby Gordon. This episode was recorded Jan. 21, 2025; information presented was current as of the date of recording.
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    26 分
  • Dr. Catriona Jamieson | The Search for Cancer Cures in Outer Space

    Dr. Catriona Jamieson | The Search for Cancer Cures in Outer Space
    2025/08/25
    This episode's conversation focuses on the innovative work of Dr. Catriona Jamieson, Director of the Sanford Stem Cell Institute at UC San Diego, and the Axiom-4 (Ax-4) launch. This space research mission includes the Institute's testing of the efficacy of "rebecsnib" on tumor organoids derived from cancer stem cells of consenting patients with secondary acute myeloid leukemia, ovarian cancer, metastatic breast cancer and glioblastoma multiforme. The drug holds potential to fight 23 types of cancer — any that involve ADAR1 in their development and progression. The hope is that the investigational new drug prevents the miniature tumors from growing, as it did on Axiom Space's previous Ax-3 mission, with cell line-derived triple negative breast cancer tumor organoids. Hosted by Bobby Gordon This episode was recorded on June 6, 2025, and information presented is accurate as of this date.
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    29 分
  • Sarah Karpen, PA-C, Stem Cell Therapies at UC San Diego

    Sarah Karpen, PA-C, Stem Cell Therapies at UC San Diego
    2025/08/22
    This episode features our conversation with Sarah Karpen, PA-C, who serves as an APP supervisor with the Alpha Clinic, CRM service, and Sanford Stem Cell Clinical Center at UC San Diego. Sarah provides an overview for what it's like to participate in regenerative medicine and stem cell clinical trials from a patient perspective, and discusses our holistic, inter-disciplinary approach to healthcare. Hosted by Bobby Gordon. This episode was recorded on January 24, 2025 and information presented is current as of this date.
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    31 分