The FDA has just dropped a bombshell that could affect nearly 2 million Americans taking natural thyroid medication. In a controversial move, they've reclassified desiccated thyroid extract, or DTE, as a biologic rather than a traditional drug. This means compounding pharmacies have exactly one year before they must stop making the customized thyroid medications that countless patients depend on. Critics are calling foul, arguing the decision is based on an inactive pig protein that gets digested in your stomach anyway, and pointing out that the real active ingredients - T4 and T3 hormones - haven't changed. What's really raising eyebrows is that this shift appears linked to a petition from AbbVie, the company behind brand-name Armour Thyroid, potentially setting up a monopoly situation.

This episode reviews information from Dr. Ryan Flannigan, a urologist specializing in reproductive and sexual medicine, and provides a comprehensive overview of penile injection therapy for erectile dysfunction. He details what the treatment entails, including common medications like Trimix and Bimix, and how it works by locally stimulating blood flow and muscle relaxation within the penis. The video outlines reasons for considering this therapy, such as failure of other treatments or nerve damage from prostate cancer, alongside contraindications like dexterity issues or bleeding disorders. A significant portion of the video is dedicated to a step-by-step guide on performing the injection safely, from preparing the medication and the injection site to delivering the dose. Finally, Dr. Flannigan addresses the critical risk of priapism (prolonged erection), explaining its dangers and providing detailed instructions on prevention and management, including when to seek emergency medical attention.

Join us as we dive into the world of testosterone therapy with insights from Dr. Khera a leading voice in men's health. With over 100 published articles, Dr. Khera brings credibility and depth to this crucial discussion. This episode serves as "Testosterone 101," cutting through the noise to explore the real risks, benefits, and the latest guidelines.

We address common myths surrounding testosterone therapy, such as its links to blood clots, heart attacks, and prostate cancer. Dr. Kara's research provides a nuanced perspective, challenging outdated assumptions and offering a comprehensive view of hormonal health.

Explore the impact of testosterone on fertility and the natural contraceptive effects it can have. We discuss alternative options like clomiphene citrate and HCG for those wanting to boost testosterone while preserving fertility.

Discover the "four pillars of testosterone optimization"—diet, exercise, sleep, and stress reduction—and how they can naturally enhance testosterone levels. Dr. Khera emphasizes the importance of these lifestyle changes in creating a balanced hormonal environment.

Looking to the future, we delve into exciting possibilities like nanotechnology and stem cell research that could revolutionize testosterone therapy. Imagine a future where lifespan is extended and hormonal health is restored naturally.

As we wrap up, the key takeaway is the importance of personalized medicine. Every individual is different, and having a knowledgeable doctor is essential for tailored treatment. Stay informed, stay curious, and make empowered decisions about your health.

This podcast episode provides an extensive discussion on the complex interplay of factors influencing male sexual function, particularly sex drive and erection quality, beyond just testosterone. It outlines the neurochemical symphony involving dopamine, serotonin, testosterone, oxytocin, and vasopressin, explaining their individual roles and interactions within the hypothalamic command center. Furthermore, the text identifies multifactorial influences on sexual dysfunction, such as obesity, diabetes, cardiovascular disease, sleep deprivation, and stress. Finally, it addresses clinical implications and treatment approaches, emphasizing lifestyle interventions, testosterone therapy considerations, and sleep optimization, underscoring that optimal sexual health is deeply interconnected with overall physical and mental well-being.

This Beyond Testosterone podcast episode comes from an academic review article from the Asian Journal of Andrology, published in September-October 2025. This article, titled "Regulation of testosterone synthesis by circadian clock genes and its research progress in male diseases," examines the relationship between circadian rhythms and testosterone production in males. It explores how circadian clock genes centrally and peripherally regulate testosterone synthesis and secretion, and how disruptions in these rhythms are linked to various male health issues, including late-onset hypogonadism, erectile dysfunction, male infertility, and prostate cancer. The authors also discuss potential therapeutic approaches, such as chronotherapy and non-pharmacological interventions, for these conditions based on circadian rhythmicity. The episode concludes by highlighting current limitations in research and suggesting future directions for investigation.

This episode addresses common misconceptions about testosterone, particularly regarding its role in women's health. She explains that testosterone is present in all bodies, not just male, and that administering testosterone to women is not illegal in the U.S., despite the lack of FDA-approved female-specific doses. Dr. Casperson clarifies that physiological female doses will not masculinize women and highlights that testosterone's benefits extend beyond libido, influencing mood, cognition, and energy. Finally, she debunks the idea that testosterone therapy negatively impacts fertility or is only for postmenopausal women, noting its linear decline with age starting in the twenties.

This podcast episode discussed Ibogaine, a powerful psychedelic with significant potential for treating addiction, trauma, and various mental health and neurological conditions. The conversation highlights Ibogaine's historical use, its unique therapeutic mechanisms, and the current landscape of its clinical application and policy in Brazil and the United States. Key themes include Ibogaine's efficacy, the critical need for safe and professionally supervised administration, challenges related to cost and stigma, and the urgent call for systemic reforms to healthcare and drug policy to maximize its accessibility and impact. The overarching message emphasizes Ibogaine's potential for "human restoration" and its role as a "genuine emancipation medication" against the backdrop of current, often ineffective, treatment models.