This episode does a deep dive into a two-year, randomized-controlled trial, investigating the effect of menopausal hormone therapy (MHT) on bone mineral density (BMD) in postmenopausal women. The study compared different dosages of conjugated equine estrogen (CEE) combined with either micronized progesterone (MP) or dydrogesterone (DHG) across three groups. Researchers measured changes in lumbar and hip BMD, along with bone metabolism biomarkers like ALP, Ca, P, Cr, and Ca/Cr, to evaluate treatment effectiveness and safety.

Zuo H, Sun A, Gao L, et al. Effect of Menopausal Hormone Therapy on Bone Mineral Density in Chinese Women: A 2-Year, Prospective, Open-Label, Randomized-Controlled Trial. Med Sci Monit. 2019;25:819-826. Published 2019 Jan 28. doi:10.12659/MSM.912166

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This episode does a deep give into a systematic review and meta-analysis investigating the connections between social media use (SMU), problematic social media use (PSMU), mental health, and sleep in young individuals. The research synthesizes findings from a large number of studies to understand these complex relationships, particularly noting the inconsistent results in previous literature. The authors aim to identify specific associations, determine directionality where possible, and explore potential moderating factors like geography, age, and gender.

Ahmed O, Walsh EI, Dawel A, Alateeq K, Espinoza Oyarce DA, Cherbuin N. Social media use, mental health and sleep: A systematic review with meta-analyses. J Affect Disord. 2024;367:701-712. doi:10.1016/j.jad.2024.08.193

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This episode dissects a qualitative study exploring patient expectations of healthcare providers concerning healthy aging. The research, based on focus group discussions with a diverse age range, identified three core themes: patients desire respect and collaboration from their providers, seek alternatives to medication including lifestyle interventions, and prioritize preventative care over solely treating existing conditions.

Duplantier SC, Undem T. Patient Expectations: A Qualitative Study on What Patients Want From Their Healthcare Providers to Support Them in Healthy Aging. Am J Lifestyle Med. Published online May 21, 2025. doi:10.1177/15598276251344856

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This episode does a deep dive into the relationship between creatine levels and mortality risk. Conducted as part of the PREVEND study in the Netherlands, the research analyzed plasma creatine concentration, estimated intramuscular creatine, and the transcellular gradient in a large population-based cohort.

Doorenbos CSE, Post A, Stegmann ME, Franssen CFM, Dullaart RPF, Navis G, Connelly MA, Bakker SJL. Plasma creatine, estimated intramuscular creatine, transcellular gradient and the risk of mortality: Results from the PREVEND study. Eur J Clin Invest. 2025;00:e70110. doi:10.1111/eci.70110

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This episode dissects an article on "Explaining Pain" (EP), a collection of educational interventions designed to alter an individual's comprehension of pain's biological underpinnings. This approach aims to reframe pain not as a direct indicator of tissue damage, but as a signal of the perceived need for bodily protection. The article explores the historical context, core objectives, and common misconceptions surrounding EP, asserting its biological plausibility and reviewing its clinical effectiveness, often in conjunction with other treatments, for reducing pain, disability, and catastrophizing in various chronic pain conditions.

Moseley GL, Butler DS. Fifteen Years of Explaining Pain: The Past, Present, and Future. J Pain. 2015;16(9):807-813. doi:10.1016/j.jpain.2015.05.005

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This episode does a deep dive on an updated approach to managing soft-tissue injuries, moving beyond traditional acronyms like RICE to the more comprehensive PEACE and LOVE framework. Ultimately, the article advocates for a holistic, patient-centered approach that prioritizes long-term outcomes and empowers individuals in their recovery process, moving away from a "magic cure" mindset.

Dubois B, Esculier JF. Soft-tissue injuries simply need PEACE and LOVE. Br J Sports Med. 2020;54(2):72-73. doi:10.1136/bjsports-2019-101253

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This episode does a deep dive investigating the acute effects of resistance training (RT) and high-intensity interval training (HIIT) on anti-cancer myokines and the suppression of breast cancer cell growth in survivors. The study randomly assigned 32 breast cancer survivors to either a single bout of RT or HIIT, collecting blood samples at baseline, immediately after exercise, and 30 minutes post-exercise.

Bettariga F, Taaffe DR, Crespo-Garcia C, et al. A single bout of resistance or high-intensity interval training increases anti-cancer myokines and suppresses cancer cell growth in vitro in survivors of breast cancer. Breast Cancer Res Treat. 2025;213:171-180. doi:10.1007/s10549-025-07772-w.

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This episode does a deep dive into a systematic review and meta-analysis of qualitative evidence concerning barriers and enablers to exercise adherence in individuals with nonspecific chronic low back pain (CLBP). The study synthesizes perceptions and beliefs from 23 papers involving 677 participants, identifying four main themes: exercise, pain, and the body; psychological factors; social factors; and external factors.

Gilanyi YL, Shah B, Cashin AG, et al. Barriers and enablers to exercise adherence in people with nonspecific chronic low back pain: a systematic review of qualitative evidence. Pain. 2024;165(10):2200-2214. doi:10.1097/j.pain.0000000000003234

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