This episode dissects a Mendelian randomization study that identifies a high body mass index (BMI) as a causal risk factor for vascular-related dementia.

Nordestgaard LT, Luo J, Emanuelsson F, et al. High body mass index as a causal risk factor for vascular-related dementia: a Mendelian randomization study. J Clin Endocrinol Metab. Published online January 22, 2026. doi:10.1210/clinem/dgaf662

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This episode dissects a randomized clinical trial that investigated whether weighted vest use or resistance training could prevent the bone density loss typically caused by intentional weight reduction in older adults with obesity. Over a 12-month period, researchers compared a diet-only group to groups adding either a weighted vest or supervised exercise to their regimen.

Beavers KM, Lynch SD, Fanning J, et al. Weighted vest use or resistance exercise to offset weight loss–associated bone loss in older adults: a randomized clinical trial. JAMA Netw Open. 2025;8(6):e2516772. doi:10.1001/jamanetworkopen.2025.16772

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This episode does a deep dive into an article that advocates for a paradigm shift in how we perceive the intervertebral disc, moving away from the idea that it is a fragile structure destined for decay.

Shala R. Rethinking the disc: from degenerative narrative to adaptive potential. Br J Sports Med. 2026;0:1-3. doi:10.1136/bjsports-2025-11087

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This episode does a deep dive into a study that evaluates the efficacy of ChatGPT-3.5 compared to certified personal trainers in providing exercise advice.

D’hoe B, Kirk D, Boone J, Colosio A. ChatGPT outperforms personal trainers in answering common exercise training questions. Journal of Sports Science and Medicine. 2026;25:235-261. doi:10.52082/jssm.2026.235

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This episode does a deep dive into an official position stand from the International Society of Sports Nutrition (ISSN) regarding the utility and safety of creatine monohydrate.

Kreider RB, Kalman DS, Antonio J, et al. International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. J Int Soc Sports Nutr. 2017;14:18. doi:10.1186/s12970-017-0173-z

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This episode evaluates how a tailored walking program combined with health education affects the recovery process for individuals experiencing a return of low back pain.

Pocovi NC, Graham P, Adelaide A, Pisharody G, Lin C, French S, et al. Effect of a walking plus education program on the duration and severity of recurrences of low back pain: a secondary exploratory analysis of the WalkBack trial. Journal of Orthopaedic & Sports Physical Therapy. Published online 2025. doi:10.2519/jospt.2025.13361

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This episode does a deep dive into a 2024 systematic review and meta-analysis examining how N-acetylcysteine (NAC) supplementation influences various biological markers following physical exertion.

Sadowski M, Zawieja E, Chmurzynska A. The impact of N-acetylcysteine on lactate, biomarkers of oxidative stress, immune response, and muscle damage: A systematic review and meta-analysis. J Cell Mol Med. 2024;28:e70198. doi:10.1111/jcmm.70198

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This episode dissects a systematic review examining how diagnostic terminology affects the treatment preferences and recovery beliefs of individuals with musculoskeletal pain.

Martin S, Smith M, Wilson DA, Zadro JR, Ferreira GE, O’Keeffe M. The effect of diagnostic labels on treatment preferences and beliefs in people with musculoskeletal pain: a systematic review of randomized trials. J Orthop Sports Phys Ther. 2026;56(1):4-15. doi:10.2519/jospt.2025.13759

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