This episode does a deep dive into a research paper that investigates whether following standard dietary guidelines provides enough flavanols to achieve the cardiovascular benefits observed in the COSMOS clinical trial.

Ottaviani JI, Erdman JW Jr, Steinberg FM, et al. Adhering to dietary guidelines does not yield flavanol intake levels associated with beneficial cardiovascular effects. Food Funct. 2026;17:5715. doi:10.1039/d6fo00867d

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This episode does a deep dive into a review paper that explores the diverse health advantages of creatine supplementation specifically for the aging population.

Evans C, Pereira F, Candow D, Antonio J. Creatine supplementation as an adjunct to improving healthy aging. Longevity. 2026;6(1):2565997. doi:10.1080/30653495.2025.2565997.

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This episode does a deep dive into a scientific review by an international panel of experts that systematically addresses and clarifies common misconceptions regarding creatine supplementation. The authors provide evidence-based refutations of myths suggesting that the supplement causes kidney damage, hair loss, or dehydration, asserting its safety for most healthy individuals.

Antonio J, Candow DG, Forbes SC, Gualano B, Jagim AR, Kreider RB, Rawson ES, Smith-Ryan AE, VanDusseldorp TA, Willoughby DS, Ziegenfuss TN. Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show? J Int Soc Sports Nutr. 2021;18:13. doi:10.1186/s12970-021-00412-w

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This episode dissects a systematic review and meta-analysis that evaluates the potential of ketamine as a novel treatment for Post-Traumatic Stress Disorder (PTSD). Researchers analyzed ten clinical studies involving 363 participants to determine if the drug effectively reduces core symptoms like avoidance and intrusion.

Almeida TM, Lacerda da Silva UR, Pires JP, et al. Effectiveness of ketamine for the treatment of post-traumatic stress disorder – a systematic review and meta-analysis. Clin Neuropsychiatr. 2024;21(1):22-31. doi:10.36131/cnfioritieditore20240102

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This episode does a deep dive into a study by Northwestern University researchers who examineed how extended overnight fasting (EOF), specifically ending meals at least three hours before sleep, impacts the health of middle-aged and older adults.

Grimaldi D, Reid KJ, Abbott SM, Knutson KL, Zee PC. Sleep-aligned Extended Overnight Fasting Improves Nighttime and Daytime Cardiometabolic Function. Arterioscler Thromb Vasc Biol. 2026;46(4):e323355. doi:10.1161/ATVBAHA.125.323355 [1, 2].

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This episode dissects the findings from the DO-HEALTH trial, a large-scale clinical study examining how vitamin D, omega-3, and exercise influence the biological aging of older adults.

Bischoff-Ferrari HA, Gängler S, Wieczorek M, et al. Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial. Nature Aging. Published online February 3, 2025. doi:10.1038/s43587-024-00793-y

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This episode dissects a systematic review and meta-analysis that evaluates the impact of exercise training on five key blood lipid markers to assist in the management of dyslipidemia.

Smart NA, Downes D, van der Touw T, et al. The effect of exercise training on blood lipids: a systematic review and meta-analysis. Sports Med. 2025;55:67-78. doi:10.1007/s40279-024-02115-z

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This episode does a deep dive into a 2026 study that investigates whether meat consumption influences cognitive decline and dementia risk based on a person's APOE genetic profile.

Norgren J, Carballo-Casla A, Grande G, Börjesson-Hanson A, Xu H, Eriksdotter M, et al. Meat consumption and cognitive health by APOE genotype. JAMA Netw Open. 2026;9(3):e266489. doi:10.1001/jamanetworkopen.2026.6489

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