Testosterone and TRT are having a moment. Public sentiment has radically shifted, often seeing it as an obvious primary intervention for men. Men's health clinics and online stores have made it easy to access. Even the US military is expanding access by checking testosterone levels for all service members 30 years old and older. But is TRT really the best answer for men who are tired or gaining weight?

Dante DiMatteo (PharmD) uses a pile of peer-reviewed studies and clinical experience to provide a balanced, fair, and honest answer to the question so many middle-aged men are facing: Why don't I feel like I used to?

IN THIS EPISODE, YOU'LL LEARN:
• Are online TRT clinics following best practices?
• Why automatic testosterone screening is a bad idea.
• What is a real Low-T score?
• What is the process for diagnosing Low-T?
• What factors impact testosterone production?
• What do testosterone levels actually signal?

We love questions. Comment below or email us: questions@askjoedimatteo.com

CONNECT:
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Questions - questions@askjoedimatteo.com
Facebook - https://facebook.com/askjoedimatteo
Instagram - https://tinyurl.com/5n6kfwhs

PODCAST:
Apple Podcasts - https://tinyurl.com/GHShowApple
Google Podcasts - https://tinyurl.com/GHShowYTM
Spotify - https://open.spotify.com/show/3B2v7PmHxLuxFoWOIWko8X?si=7ae14c5e6d1e449a
Rumble - https://rumble.com/user/GenerationHealth
YouTube Podcast - https://www.youtube.com/@GenerationHealthShow
YouTube Clips - https://www.youtube.com/@askjoedimatteo

Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life!

CHAPTERS:
00:00 - Show Intro
00:51 - New Department of War policy on Testosterone
02:38 - Information comes with a catch
03:54 - When is testosterone screening worthwhile?
04:42 - Testosterone is a proxy.
05:51 - Online TRT Clinics vs Guidelines
06:12 - Study findings
06:55 - What 90% of TRT Sites got right
07:26 - What does a real diagnosis look like?
08:31 - One-third of retests return to normal
10:00 - Medications that can lower testosterone
11:25 - What number is actually low?
13:36 - Pete Hegseth's Official Announcement
16:08 - Why TRT seems to work
18:21 - Is TRT dangerous?
20:00 - How does TRT impact fertility?
20:57 - Reasonable TRT results
25:09 - What's most likely causing Testosterone decline
27:28 - TRT will help specific men
28:19 - Where to do before TRT
30:18 - Summary

SHOW NOTES:
1) Online Clinic Discrepancies (Study): https://academic.oup.com/jcem/article/111/6/1651/8414025
2) Sec Hegseth Announcement (Video): https://x.com/SecWar/status/2077425458430230838?s=20
3) Testosterone in Healthy Man (Study): https://doi.org/10.1111/j.1365-2265.2012.04432.x
4) Aging Men Testosterone & Function (Study): https://doi.org/10.1530/EJE%2D12%2D0890
5) Endocrine Society Statement: https://www.endocrine.org/news-and-advocacy/news-room/2026/statement-on-testosterone-replacement-therapy
6) Mood & Agression in men on High-dose Testosterone (Study): https://doi.org/10.1001/archpsyc.57.2.133
7) TRAVERSE (Study): https://doi.org/10.1056/NEJMoa2215025
8) Testosterone May Improve Mood & Sexual Function (Study): https://doi.org/10.1136/bmj.i989

DISCLAIMER:
This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

Not all sleep aids are created equal. With dozens of options available ranging from natural supplements to prescription medications, finding the solution that will get you to sleep, keep you asleep, and not have unwanted side effects can be a challenge.

That's why pharmacist and nutritionist Joey DiMatteo is making it easy by ranking them! He discusses the ones that work, the ones don't, and how to choose based on the particular challenge you're facing.

After that, Dante DiMatteo (PharmD) goes over a study directly linking strength in older women to longevity. There are a host of reasons women over 60 should do resistance training, but a 33% reduced risk of mortality has to be one of the best!

IN THIS EPISODE, YOU'LL LEARN:
• Which sleep aids work best.
• How to find the root of your sleep disturbance.
• Which prescription sleep aids a pharmacist would never take.
• When it's time for a sleep study.
• What single factor reduces risk of mortality by 33% in women 63+.

We love questions. Comment below or email us: questions@askjoedimatteo.com

CONNECT:
Products - https://askjoedimatteo.com/youtube
Questions - questions@askjoedimatteo.com
Facebook - https://facebook.com/askjoedimatteo
Instagram - https://tinyurl.com/5n6kfwhs

PODCAST:
Apple Podcasts - https://tinyurl.com/GHShowApple
Google Podcasts - https://tinyurl.com/GHShowYTM
Spotify - https://open.spotify.com/show/3B2v7PmHxLuxFoWOIWko8X?si=7ae14c5e6d1e449a
Rumble - https://rumble.com/user/GenerationHealth
YouTube Podcast - https://www.youtube.com/@GenerationHealthShow
YouTube Clips - https://www.youtube.com/@askjoedimatteo

Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life!

CHAPTERS:
00:00 - Show Intro
00:40 - How we rank sleep aids
01:32 - Alcohol
02:31 - Anti-psychotics (Seroquel)
03:12 - Over-the-counter options
04:14 - Z-drugs (Ambien, Lunesta, Sonata)
05:20 - Benzodiazepine
06:20 - Trazodone
07:31 - Melatonin
09:22 - Supplement Blends
11:31 - Doxepin (low dose) & Ramelteon
12:28 - Dayvigo & Belsomra (orexin receptor antagonist)
13:34 - The only A+ intervention: CBT-I
15:01 - Ranking Recap
15:44 - Takeaway: Find the root problem first.
16:39 - Muscular Strength & Mortality in women 63-99
17:12 - How the study was designed
18:24 - Findings of the study
21:34 - Grip strength is a proxy, not a goal.
23:18 - Takeaway: Exercise is safe & effective
24:54 - Show Outro

SHOW NOTES:
1) Muscular Strength & Mortality (Study):
• https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2845052

DISCLAIMER:
This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

Nearly 80 percent of adults over 65 take at least one dietary supplement, and 60 percent of all adults use them daily. But does every bottle contain what the label claims?

In this episode of Generation Health, pharmacist and nutritionist Joey DiMatteo breaks down the reality of FDA supplement regulation. He evaluates the American College of Physicians' push for stricter laws, analyzes quality studies on popular supplements, and shares a 5-question checklist you should ask before taking any pill in your cabinet.

IN THIS EPISODE, YOU'LL LEARN:
• The FDA Reality: What "Good Manufacturing Practices" cover and how supplement rules differ from drug approvals.
• Label Accuracy: What recent testing reveals about melatonin gummies, immune formulas, and weight-loss products.
• The ACP Proposal: The push for mandatory FDA registration, premarket reviews, and USP quality standards, and more...
• The 5-Question Framework: A practical checklist to evaluate any supplement for safety, dosing, and drug interactions.

We love questions. Comment below or email us: questions@askjoedimatteo.com

CONNECT:
Products - https://askjoedimatteo.com/youtube
Questions - questions@askjoedimatteo.com
Facebook - https://facebook.com/askjoedimatteo
Instagram - https://tinyurl.com/5n6kfwhs

PODCAST:
Apple Podcasts - https://tinyurl.com/GHShowApple
Google Podcasts - https://tinyurl.com/GHShowYTM
Spotify - https://open.spotify.com/show/3B2v7PmHxLuxFoWOIWko8X?si=7ae14c5e6d1e449a
Rumble - https://rumble.com/user/GenerationHealth
YouTube Podcast - https://www.youtube.com/@GenerationHealthShow
YouTube Clips - https://www.youtube.com/@askjoedimatteo

Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life!

CHAPTERS:
00:00 - Show Intro
00:40 - Why the American College of Physicians claims supplements are under-regulated.
02:07 - What recent JAMA research reveals about modern supplement consumption trends.
03:40 - How FDA oversight actually works for dietary supplements.
04:42 - Difference between supplements and medications
06:52 - Are products being mislabeled?
08:40 - FDA Warning Analysis
09:23 - New England Journal of Medicine Analysis
10:41 - What does the ACP want to change regarding supplements?
14:05 - 5-questions to ask about every supplement yout take.
16:55 - The Bottom Line: Regulation should raise quality without limiting access.

SHOW NOTES:
1) American College of Physicians position paper:
• https://www.acpjournals.org/doi/10.7326/ANNALS-26-01119
2) 2026 JAMA Network Open supplement-use analysis:
• https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2850245
3) CGMPs for Supplements:
• https://www.fda.gov/food/guidance-regulation-food-and-dietary-supplements/current-good-manufacturing-practices-cgmps-food-and-dietary-supplements
4) FDA dietary-supplement regulation Q&A:
• https://www.fda.gov/food/information-consumers-using-dietary-supplements/questions-and-answers-dietary-supplements
5) Immune-support product analysis:
• https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2794987
6) Weight-loss product analysis:
• https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2818120
7) Melatonin gummy analysis:
• https://jamanetwork.com/journals/jama/fullarticle/2804077
8) Unapproved Rx in Supplements:
• https://pubmed.ncbi.nlm.nih.gov/30646238/
9) Supplement-related emergency visits:
• https://pmc.ncbi.nlm.nih.gov/articles/PMC6196363/

DISCLAIMER:
This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

We're celebrating our 100th episode by answering YOUR questions! Joey DiMatteo (PharmD CCN) and Dante DiMatteo (PharmD) answer questions about a wide variety of concerns like supplement interactions, vitamin dosage changes, medication timing, petroleum based supplements and more. They bring their years of experience as practicing pharmacists to bear with honest, direct answers to common family medicine questions!

IN THIS EPISODE, YOU'LL LEARN:

• How natural supplements can interact with medications.

• Does it matter what time of day you take prescribed medication?

• Do medicines like Provigil drain nutrients from our bodies?

• Are "whole-food" supplements better than other high-quality natural supplements?

... and more!

We love questions. Comment below or email us: questions@askjoedimatteo.com

CONNECT:
Products - https://askjoedimatteo.com/youtube
Questions - questions@askjoedimatteo.com
Facebook - https://facebook.com/askjoedimatteo
Instagram - https://tinyurl.com/5n6kfwhs

PODCAST:
Apple Podcasts - https://tinyurl.com/GHShowApple
Google Podcasts - https://tinyurl.com/GHShowYTM
Spotify - https://open.spotify.com/show/3B2v7PmHxLuxFoWOIWko8X?si=7ae14c5e6d1e449a
Rumble - https://rumble.com/user/GenerationHealth
YouTube Podcast - https://www.youtube.com/@GenerationHealthShow
YouTube Clips - https://www.youtube.com/@askjoedimatteo

Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life!

CHAPTERS:

00:00 - Show Intro
01:54 - Using CoQ10 with Xarelto
07:30 - Concerns when reducing D3 and B12 supplementation
12:40 - Can you change the time at which you take your medications?
19:47 - What nutrients does Provigil deplete from our bodies?
28:15 - Are whole food fermented vitamins better for you?
38:03 - Show Outro

DISCLAIMER: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

Is AI ready to take you from fat to fit? That's what researchers hoped to answer in a recent clinical study. Looking at three different models of ChatGPT, professional trainers analyzed 12 week training programs the AI provided based on hypothetical users. Dante DiMatteo, a human personal trainer, digs through the data to show what worked and where having an experienced human to guide is a good idea.

IN THIS EPISODE, YOU'LL LEARN:
• Where AI excelled at creating a program, and where it still lags.
• How to spot mistakes & unsafe suggestions in any training program.
• How to construct a prompt that will deliver excellent results for anyone looking to start exercising, regardless of starting point or end goal.
• What is the "roman chair" and why does Josiah want one?

Subscribe to join a community of health-conscious individuals seeking clinical clarity.

We love questions. Comment below or email us: questions@askjoedimatteo.com

CONNECT:
Products - https://askjoedimatteo.com/youtube
Questions - questions@askjoedimatteo.com
Facebook - https://facebook.com/askjoedimatteo
Instagram - https://tinyurl.com/5n6kfwhs

PODCAST:
Apple Podcasts - https://tinyurl.com/GHShowApple
Google Podcasts - https://tinyurl.com/GHShowYTM
Spotify - https://open.spotify.com/show/3B2v7PmHxLuxFoWOIWko8X?si=7ae14c5e6d1e449a
Rumble - https://rumble.com/user/GenerationHealth
YouTube Podcast - https://www.youtube.com/@GenerationHealthShow
YouTube Clips - https://www.youtube.com/@askjoedimatteo

Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life!

CHAPTERS:
00:00 - Show Intro
02:13 - AI Training Study
05:54 - Blinding of the study
08:28 - Where the AI Failed
11:39 - Individualization
12:26 - Safety and Injury Prevention
13:52 - Additional Studies
16:14 - How Dante uses AI
19:00 - Brainstorming Ideas
23:09 - Chat GPT exercise ad
28:51 - Additional AI banter
33:24 - How can a normal person use this information?
38:46 - Show Outro

SHOW NOTES:
1) Comparative evaluation of ChatGPT versions in training program design
• https://pmc.ncbi.nlm.nih.gov/articles/PMC12797729/

DISCLAIMER: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

In Episode 096, Joey DiMatteo (PharmD, CCN) digs through two decades of neuroplasticity research to uncover how our internal "mental scripts"—the beliefs we hold about ourselves and our world—are physically wired into our brain architecture.

While these patterns are difficult to change as adults, the science reveals a profound window of opportunity in early childhood. We explore how a parent's tone and emotional expression act as a "neural blueprint," physically shaping a child's amygdala and impacting the generations to come.

Then, we turn to a pharmacist FAQ. The question "Is it still safe to take this?" is a daily occurrence for Joey. Unfortunately, the answer isn't a simple yes or no. Joey explains the reasons behind expiration dates, and gives a definitive answer on which medications should NEVER be used after expiration.

In this episode, we discuss:
- The Rewiring Process: How to identify and overwrite the stories we tell ourselves.
- The Power of Tone: The specific clinical link between parental expression and a child's neurological development.
- The Fatherhood Reflection: A candid look at our own mistakes as fathers and how the science of neuroplasticity offers a path to do better.
- Rx Safety Alert: A critical breakdown of the history of expiration dates and the specific medications that become dangerous—not just less effective—after their "use by" date.

Stop the information overload and gain a usable wisdom for navigating family medicine & natural health.

We love questions! Comment below or email us: questions@askjoedimatteo.com

CONNECT:
Products - https://askjoedimatteo.com/youtube
Questions - questions@askjoedimatteo.com
Facebook - https://facebook.com/askjoedimatteo
Instagram - https://tinyurl.com/5n6kfwhs

PODCAST:
Apple Podcasts - https://tinyurl.com/GHShowApple
Google Podcasts - https://tinyurl.com/GHShowYTM
Spotify - https://tinyurl.com/GHShowSpotify
Rumble - https://rumble.com/user/GenerationHealth
YouTube - https://tinyurl.com/57hxe6aj
YouTube Clips - https://tinyurl.com/wzk69tbk

Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life!

CHAPTERS:
00:26 - Show Intro
01:05 - Positive Thinking!?
02:16 - What is Neuroplasticity?
04:49 - The science behind neuroplasticity
06:27 - Negative Thinking
12:43 - Stoicism
15:46 - How do we change our minds?
17:23 - Neuroplasticity in Children
26:51 - Real world application
29:24 - Confirmation bias
31:51 - Medication Expiration
32:45 - Why did expiration dates first come about?
34:49 - US DOD study
35:40 - High risk categories
37:31 - Antibiotics
42:40 - Show outro

SHOW NOTES:
1) Nature experience reduces rumination (NIH) - https://tinyurl.com/yc5z77tf
2) Self-affirmation activates brain (NIH) - https://tinyurl.com/yrrzexx4
3) Adolescent Brain Structure (NIH) - https://tinyurl.com/3xm3pbz3
4) Neurobiology of Stress and Development (NIH) - https://tinyurl.com/mxne2dx5
5) Mirror Systems in Emotions (NIH) - https://tinyurl.com/4s2cxeyd
6) Affect Contagion Between Mothers and Infants (NIH) - https://pmc.ncbi.nlm.nih.gov/articles/PMC5499532/
7) Negative Attribution Styles Predict Depression (NIH) - https://tinyurl.com/msewskfw

DISCLAIMER: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.