Testosterone and TRT are having a moment. Public sentiment has radically shifted, often seeing it as an obvious primary intervention for men. Men's health clinics and online stores have made it easy to access. Even the US military is expanding access by checking testosterone levels for all service members 30 years old and older. But is TRT really the best answer for men who are tired or gaining weight?

Dante DiMatteo (PharmD) uses a pile of peer-reviewed studies and clinical experience to provide a balanced, fair, and honest answer to the question so many middle-aged men are facing: Why don't I feel like I used to?

IN THIS EPISODE, YOU'LL LEARN:
• Are online TRT clinics following best practices?
• Why automatic testosterone screening is a bad idea.
• What is a real Low-T score?
• What is the process for diagnosing Low-T?
• What factors impact testosterone production?
• What do testosterone levels actually signal?

We love questions. Comment below or email us: questions@askjoedimatteo.com

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Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life!

CHAPTERS:
00:00 - Show Intro
00:51 - New Department of War policy on Testosterone
02:38 - Information comes with a catch
03:54 - When is testosterone screening worthwhile?
04:42 - Testosterone is a proxy.
05:51 - Online TRT Clinics vs Guidelines
06:12 - Study findings
06:55 - What 90% of TRT Sites got right
07:26 - What does a real diagnosis look like?
08:31 - One-third of retests return to normal
10:00 - Medications that can lower testosterone
11:25 - What number is actually low?
13:36 - Pete Hegseth's Official Announcement
16:08 - Why TRT seems to work
18:21 - Is TRT dangerous?
20:00 - How does TRT impact fertility?
20:57 - Reasonable TRT results
25:09 - What's most likely causing Testosterone decline
27:28 - TRT will help specific men
28:19 - Where to do before TRT
30:18 - Summary

SHOW NOTES:
1) Online Clinic Discrepancies (Study): https://academic.oup.com/jcem/article/111/6/1651/8414025
2) Sec Hegseth Announcement (Video): https://x.com/SecWar/status/2077425458430230838?s=20
3) Testosterone in Healthy Man (Study): https://doi.org/10.1111/j.1365-2265.2012.04432.x
4) Aging Men Testosterone & Function (Study): https://doi.org/10.1530/EJE%2D12%2D0890
5) Endocrine Society Statement: https://www.endocrine.org/news-and-advocacy/news-room/2026/statement-on-testosterone-replacement-therapy
6) Mood & Agression in men on High-dose Testosterone (Study): https://doi.org/10.1001/archpsyc.57.2.133
7) TRAVERSE (Study): https://doi.org/10.1056/NEJMoa2215025
8) Testosterone May Improve Mood & Sexual Function (Study): https://doi.org/10.1136/bmj.i989

DISCLAIMER:
This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.