Testosterone and TRT are having a moment. Public sentiment has radically shifted, often seeing it as an obvious primary intervention for men. Men's health clinics and online stores have made it easy to access. Even the US military is expanding access by checking testosterone levels for all service members 30 years old and older. But is TRT really the best answer for men who are tired or gaining weight?

Dante DiMatteo (PharmD) uses a pile of peer-reviewed studies and clinical experience to provide a balanced, fair, and honest answer to the question so many middle-aged men are facing: Why don't I feel like I used to?

IN THIS EPISODE, YOU'LL LEARN:
• Are online TRT clinics following best practices?
• Why automatic testosterone screening is a bad idea.
• What is a real Low-T score?
• What is the process for diagnosing Low-T?
• What factors impact testosterone production?
• What do testosterone levels actually signal?

We love questions. Comment below or email us: questions@askjoedimatteo.com

CONNECT:
Products - https://askjoedimatteo.com/youtube
Questions - questions@askjoedimatteo.com
Facebook - https://facebook.com/askjoedimatteo
Instagram - https://tinyurl.com/5n6kfwhs

PODCAST:
Apple Podcasts - https://tinyurl.com/GHShowApple
Google Podcasts - https://tinyurl.com/GHShowYTM
Spotify - https://open.spotify.com/show/3B2v7PmHxLuxFoWOIWko8X?si=7ae14c5e6d1e449a
Rumble - https://rumble.com/user/GenerationHealth
YouTube Podcast - https://www.youtube.com/@GenerationHealthShow
YouTube Clips - https://www.youtube.com/@askjoedimatteo

Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life!

CHAPTERS:
00:00 - Show Intro
00:51 - New Department of War policy on Testosterone
02:38 - Information comes with a catch
03:54 - When is testosterone screening worthwhile?
04:42 - Testosterone is a proxy.
05:51 - Online TRT Clinics vs Guidelines
06:12 - Study findings
06:55 - What 90% of TRT Sites got right
07:26 - What does a real diagnosis look like?
08:31 - One-third of retests return to normal
10:00 - Medications that can lower testosterone
11:25 - What number is actually low?
13:36 - Pete Hegseth's Official Announcement
16:08 - Why TRT seems to work
18:21 - Is TRT dangerous?
20:00 - How does TRT impact fertility?
20:57 - Reasonable TRT results
25:09 - What's most likely causing Testosterone decline
27:28 - TRT will help specific men
28:19 - Where to do before TRT
30:18 - Summary

SHOW NOTES:
1) Online Clinic Discrepancies (Study): https://academic.oup.com/jcem/article/111/6/1651/8414025
2) Sec Hegseth Announcement (Video): https://x.com/SecWar/status/2077425458430230838?s=20
3) Testosterone in Healthy Man (Study): https://doi.org/10.1111/j.1365-2265.2012.04432.x
4) Aging Men Testosterone & Function (Study): https://doi.org/10.1530/EJE%2D12%2D0890
5) Endocrine Society Statement: https://www.endocrine.org/news-and-advocacy/news-room/2026/statement-on-testosterone-replacement-therapy
6) Mood & Agression in men on High-dose Testosterone (Study): https://doi.org/10.1001/archpsyc.57.2.133
7) TRAVERSE (Study): https://doi.org/10.1056/NEJMoa2215025
8) Testosterone May Improve Mood & Sexual Function (Study): https://doi.org/10.1136/bmj.i989

DISCLAIMER:
This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

Not all sleep aids are created equal. With dozens of options available ranging from natural supplements to prescription medications, finding the solution that will get you to sleep, keep you asleep, and not have unwanted side effects can be a challenge.

That's why pharmacist and nutritionist Joey DiMatteo is making it easy by ranking them! He discusses the ones that work, the ones don't, and how to choose based on the particular challenge you're facing.

After that, Dante DiMatteo (PharmD) goes over a study directly linking strength in older women to longevity. There are a host of reasons women over 60 should do resistance training, but a 33% reduced risk of mortality has to be one of the best!

IN THIS EPISODE, YOU'LL LEARN:
• Which sleep aids work best.
• How to find the root of your sleep disturbance.
• Which prescription sleep aids a pharmacist would never take.
• When it's time for a sleep study.
• What single factor reduces risk of mortality by 33% in women 63+.

We love questions. Comment below or email us: questions@askjoedimatteo.com

CONNECT:
Products - https://askjoedimatteo.com/youtube
Questions - questions@askjoedimatteo.com
Facebook - https://facebook.com/askjoedimatteo
Instagram - https://tinyurl.com/5n6kfwhs

PODCAST:
Apple Podcasts - https://tinyurl.com/GHShowApple
Google Podcasts - https://tinyurl.com/GHShowYTM
Spotify - https://open.spotify.com/show/3B2v7PmHxLuxFoWOIWko8X?si=7ae14c5e6d1e449a
Rumble - https://rumble.com/user/GenerationHealth
YouTube Podcast - https://www.youtube.com/@GenerationHealthShow
YouTube Clips - https://www.youtube.com/@askjoedimatteo

Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life!

CHAPTERS:
00:00 - Show Intro
00:40 - How we rank sleep aids
01:32 - Alcohol
02:31 - Anti-psychotics (Seroquel)
03:12 - Over-the-counter options
04:14 - Z-drugs (Ambien, Lunesta, Sonata)
05:20 - Benzodiazepine
06:20 - Trazodone
07:31 - Melatonin
09:22 - Supplement Blends
11:31 - Doxepin (low dose) & Ramelteon
12:28 - Dayvigo & Belsomra (orexin receptor antagonist)
13:34 - The only A+ intervention: CBT-I
15:01 - Ranking Recap
15:44 - Takeaway: Find the root problem first.
16:39 - Muscular Strength & Mortality in women 63-99
17:12 - How the study was designed
18:24 - Findings of the study
21:34 - Grip strength is a proxy, not a goal.
23:18 - Takeaway: Exercise is safe & effective
24:54 - Show Outro

SHOW NOTES:
1) Muscular Strength & Mortality (Study):
• https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2845052

DISCLAIMER:
This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

Nearly 80 percent of adults over 65 take at least one dietary supplement, and 60 percent of all adults use them daily. But does every bottle contain what the label claims?

In this episode of Generation Health, pharmacist and nutritionist Joey DiMatteo breaks down the reality of FDA supplement regulation. He evaluates the American College of Physicians' push for stricter laws, analyzes quality studies on popular supplements, and shares a 5-question checklist you should ask before taking any pill in your cabinet.

IN THIS EPISODE, YOU'LL LEARN:
• The FDA Reality: What "Good Manufacturing Practices" cover and how supplement rules differ from drug approvals.
• Label Accuracy: What recent testing reveals about melatonin gummies, immune formulas, and weight-loss products.
• The ACP Proposal: The push for mandatory FDA registration, premarket reviews, and USP quality standards, and more...
• The 5-Question Framework: A practical checklist to evaluate any supplement for safety, dosing, and drug interactions.

We love questions. Comment below or email us: questions@askjoedimatteo.com

CONNECT:
Products - https://askjoedimatteo.com/youtube
Questions - questions@askjoedimatteo.com
Facebook - https://facebook.com/askjoedimatteo
Instagram - https://tinyurl.com/5n6kfwhs

PODCAST:
Apple Podcasts - https://tinyurl.com/GHShowApple
Google Podcasts - https://tinyurl.com/GHShowYTM
Spotify - https://open.spotify.com/show/3B2v7PmHxLuxFoWOIWko8X?si=7ae14c5e6d1e449a
Rumble - https://rumble.com/user/GenerationHealth
YouTube Podcast - https://www.youtube.com/@GenerationHealthShow
YouTube Clips - https://www.youtube.com/@askjoedimatteo

Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life!

CHAPTERS:
00:00 - Show Intro
00:40 - Why the American College of Physicians claims supplements are under-regulated.
02:07 - What recent JAMA research reveals about modern supplement consumption trends.
03:40 - How FDA oversight actually works for dietary supplements.
04:42 - Difference between supplements and medications
06:52 - Are products being mislabeled?
08:40 - FDA Warning Analysis
09:23 - New England Journal of Medicine Analysis
10:41 - What does the ACP want to change regarding supplements?
14:05 - 5-questions to ask about every supplement yout take.
16:55 - The Bottom Line: Regulation should raise quality without limiting access.

SHOW NOTES:
1) American College of Physicians position paper:
• https://www.acpjournals.org/doi/10.7326/ANNALS-26-01119
2) 2026 JAMA Network Open supplement-use analysis:
• https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2850245
3) CGMPs for Supplements:
• https://www.fda.gov/food/guidance-regulation-food-and-dietary-supplements/current-good-manufacturing-practices-cgmps-food-and-dietary-supplements
4) FDA dietary-supplement regulation Q&A:
• https://www.fda.gov/food/information-consumers-using-dietary-supplements/questions-and-answers-dietary-supplements
5) Immune-support product analysis:
• https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2794987
6) Weight-loss product analysis:
• https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2818120
7) Melatonin gummy analysis:
• https://jamanetwork.com/journals/jama/fullarticle/2804077
8) Unapproved Rx in Supplements:
• https://pubmed.ncbi.nlm.nih.gov/30646238/
9) Supplement-related emergency visits:
• https://pmc.ncbi.nlm.nih.gov/articles/PMC6196363/

DISCLAIMER:
This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.