Takeaways

• MASH is a significant obesity-related complication.
• Semaglutide shows promise in treating MASH.
• Weight loss is crucial for improving liver health.
• Bariatric surgery remains the most effective treatment.
• The Essence trial indicates a 63% resolution of NASH.
• New medications are being developed for obesity treatment.
• Early intervention is key to preventing severe liver damage.
• Accessibility of medications is a major concern.
• Comparative studies are essential for evaluating new treatments.
• Future treatments may include innovative delivery methods.

Chapters

00:00 Introduction to MASH and Semaglutide Study

04:29 Understanding Metabolic Dysfunction and Its Implications

08:02 Essence Trial: Semaglutide's Impact on MASH

12:58 Comparative Analysis of New Treatments for MASH

17:30 The Future of Obesity Treatment and Drug Accessibility

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Drs. Karl and Spencer chat with return guest Dr. Lauren Semple about creatine, protein, cortisol, fasting exercise, and training in women.

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Drs. Karl and Spencer discuss a new study looking at tirzepatide and metabolic rate. They also discuss a patient case of tirzepatide induced anhedonia.

Here is the tirzepatide study

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Drs. Karl and Spencer discuss the claim that GLP-1 meds cause more fat cells.

Learn about if and how GLP-1 meds increase fat cells and what that means along with other claims about these medicine.

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Drs. Karl and Spencer talk to Dr. Kenneth Qiu all about direct medical care - the future of medicine.

Learn about how bypassing insurance and creating a relationship directly with a doctor can improve your health and save money in the long run.

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Drs. Karl and Spencer discuss with Dr. Grant Tinsley all about the new analysis of how much "lean mass" is lost with tirzepatide, the most powerful medicine available for weight loss.

Learn:

The difference between fat free mass and lean mass and lean soft tissue and muscle.

If GLP-1 medicines cause muscle loss specifically

How to minimize muscle loss when taking these medicines

Our new study together.

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Drs. Karl and Spencer discuss how bad the Hims and Hers ad was.

From an outside perspective, the ad may have seemed good.

But when you dig deeper, it was actually really bad.

Listen to learn.

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Drs. Karl and Spencer chat with NMN and NAD expert Dr. Charles Brenner all about these supposed longevity supplements.

Learn about NAD metabolism

Whether it's worth supplementing or not with NAD or NMN

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