検索キーワード： 遺伝子

19世紀後半にメンデルが発見した遺伝の法則とダーウィンの進化論が出会い、遺伝学は歩み始めた。そして今、人類はゲノム編集の時代を迎えている。遺伝子が握る人類の運命とは？　ピュリッツァー賞受賞の医学者が自らの家系に潜む精神疾患の悲劇を織り交ぜながら、圧倒的なストーリーテリングで紡ぐ遺伝子全史

2000年代初頭、人間の全遺伝情報=ヒトゲノムがついに解読された。その後まもなく、山中伸弥らがiPS細胞(人工多能性幹細胞)の作製に成功。そして今、ジェニファー・ダウドナらが開発した新技術「CRISPR-Cas9」により、人類は「ゲノム編集」の時代を迎えている。自らの設計図を望み通りに書き換えられるようになったとき、人間の条件はどう変わるのか? 科学と倫理のせめぎ合いを圧倒的なストーリーテリングで描く傑作。

The Gene is the story of one of the most powerful and dangerous ideas in our history, from best-selling, prize-winning author Siddhartha Mukherjee. Spanning the globe and several centuries, The Gene is the story of the quest to decipher the master code that makes and defines humans, that governs our form and function. The story of the gene begins in an obscure Augustinian abbey in Moravia in 1856, where a monk stumbles on the idea of a 'unit of heredity'.

In the early 1800s, a century before there was any concept of the gene, physicians in insane asylums began to record causes of madness in their admission books. Almost from the beginning, they pointed to heredity as the most important of these causes. As doctors and state officials steadily lost faith in the capacity of asylum care to stem the terrible increase of insanity, they began emphasizing the need to curb the reproduction of the insane. They became obsessed with identifying weak or tainted families and anticipating the outcomes of their marriages.

From an acclaimed Harvard professor and one of Time’s most influential people, this paradigm-shifting audiobook shows how almost everything we think we know about aging is wrong, offers a front-row seat to the amazing global effort to slow, stop, and reverse aging, and calls listeners to consider a future where aging can be treated.

Around 250,000 people have had their genomes sequenced, and scientists expect that number to rise to one billion by 2025. Professor Steven J. Heine argues that the first thing we will do on receiving our DNA test results is to misinterpret them completely. Despite breathless (often lightly researched) media coverage about newly discovered "cancer" or "divorce" or "IQ" genes, the prospect of a DNA test forecasting how your life is going to turn out is vanishingly small.

In Beat the Heart Attack Gene, world-renowned cardiovascular specialists Bradley Bale, MD, and Amy Doneen, ARNP, present a new model for understanding and preventing heart disease. They explain the three different genetic types of cholesterol profiles and tailor treatments for each type, using their cutting-edge Bale/Doneen Method, a simple, comprehensive prevention plan that detects cardiovascular disease (CVD) at early stages.

Since 2010, it has been possible to determine a person's genetic makeup in a matter of days at an accessible cost for many millions of people. Along with this technological breakthrough there has emerged a movement to use this information to help prospective parents "eliminate preventable genetic disease". As the prospect of systematically excluding the appearance of unwanted mutations in our children comes within reach, David B. Goldstein examines the possible consequences from these types of choices.

The extraordinary Siddhartha Mukherjee has written a biography of the gene as deft, brilliant, and illuminating as his extraordinarily successful biography of cancer. Weaving science, social history, and personal narrative to tell us the story of one of the most important conceptual breakthroughs of modern times, Mukherjee animates the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices.

The body is magnificent but it doesn't come with a lifetime warranty or an operating manual. You're the result of millions of years of evolution, but many of the adaptations that helped your ancestors survive are now working overtime to accelerate the aging process. The assumption here is that we are our genes and therefore trapped by the past. The good news is that your genetic code - the DNA sequence that is the biochemical basis of heredity - can play a minor role in the way you age.

Imagine a future where we grow houses rather than build them. Where smartphones are living, clothing has opinions, and all human knowledge fits into a speck of DNA. A world where disease is a thing of the past, and the human lifespan is dramatically extended. To achieve this, says Adrian Woolfson – founder of the genome writing company Genyro – we must transform biology into a predictive, programmable engineering material. That means decoding the generative grammar of DNA: the language of life itself. We will then be able to author genomes – and, if we choose, even rewrite our own.

Could illness be a blessing in disguise; a positive life-changing experience? When the worst imaginable happens, how do you react? Do you wonder “why me,” or “what did I do to deserve this?” Or do you look for the gifts it brings? Filled with intriguing stories of people who have experienced life-altering diagnoses, The Other Side of Illness: Unexpected Blessings demonstrates that every health adversity can result in remarkable beneficial life changes.

Despite the incredible strain of all these challenges, Mindy manages them with amazing tenderness, persistence, and love. Far from a depressing story of misfortune, Last Nerve is as uplifting and witty as it is raw and real. It’s a testament to hope, the endurance of family, and the resilience of the human spirit.

Born with a rare, incurable genetic disorder that doctors misdiagnosed until her 30s, Amy’s right leg swelled until it was 200 percent bigger than her left leg. Her peers bullied her for having an “elephant leg,” and she learned to hide her disability by wearing skirts. In an attempt to recreate her identity as a teenager, she competed in the Miss Junior American Coed Pageant, and—to her shock—she won, only to become known as “the beauty queen with the big leg”.

A completely new way to look at fat loss, autoimmune conditions, and optimal health. What if that banana you had for breakfast was actually sabotaging your health efforts? Health, metabolism, and weight are controlled by both our genetics and our lifestyle, in essence a balance between nature and nurture. By identifying our strengths and our weaknesses genetically, as well as our body chemistry through advanced targeted testing, we now have the ability to influence our health like never before.

In this book, biotechnology entrepreneur and CEO of The DNA Company Kashif Khan offers an action plan to help you live your best life. It starts by understanding your genetic makeup.

If you or someone you love has Retinitis Pigmentosa (RP), the genetic condition that is passed down from one generation to the next, please keep reading. RP is not funny as it can be the cause of loss of vision, either in adults or children. Its effect on vision can be slow-moving or it can progress very quickly. The author has been affected for over 30 years and understands the emotional toll this condition can have on the newly diagnosed.

A coming-of-age memoir for modern times, Bleeder is the incredibly compelling tale of author Shelby Smoak. A hemophiliac, Smoak discovered he had been infected with HIV during a blood transfusion at the start of his college career. This devastating and destabilizing news led Smoak to see his world from an entirely new perspective, one in which life-threatening illness was perpetually just around the corner. Set in the 1990s along the North Carolina coast, Bleeder traces Smoak’s quest for love in a world that feels increasingly dangerous.

A new gene editing technology, invented just seven years ago, has turned humanity into gods. Enabling us to manipulate the genes in virtually any organism with exquisite precision, CRISPR has given scientists a degree of control that was undreamt of even in science fiction. But CRISPR is just the latest, giant leap in a long journey to master genetics. The Genetic Age shows the astonishing, world-changing potential of the new genetics and the possible threats it poses, sifting between fantasy and the reality when it comes to both benefits and dangers.

A tiny mutation on the X chromosome can shape a family’s history. Passed down from a “carrier” parent to a child, fragile X syndrome is the most common inherited cause of intellectual disability and autism. Beyond that—and a rarity among genetic disorders—some fragile X carriers not only transmit the mutation, but also experience related conditions themselves.