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Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they speak with Dr. Jens Juul Holst, the renowned Danish physiologist and co-discoverer of GLP-1 (glucagon-like peptide-1), one of the most significant hormones in metabolic disease research. A professor of medical physiology at the University of Copenhagen and former scientific director at the Novo Nordisk Foundation Center for Basic Metabolic Research, Dr. Holst has spent decades unraveling the gut’s intricate role in glucose metabolism and appetite regulation.

In this interview, Dr. Holst reflects on his journey from surgical training to groundbreaking endocrinology, detailing how GLP-1 emerged as a therapeutic cornerstone in the treatment of type 2 diabetes and obesity. He explores its far-reaching effects—ranging from cardiovascular and neuroprotective benefits to appetite and weight regulation—and shares insight into the future of metabolic therapies, including combination treatments and oral delivery strategies.

With honors including the Banting Medal, the Canada Gairdner Award, and the Breakthrough Prize in Life Sciences, Dr. Holst’s work has helped transform the landscape of modern medicine. This episode offers a compelling look at the science behind GLP-1 and the global impact of one of the most important endocrine discoveries of our time.

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Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they interview Brady Holmer, an exercise physiologist, researcher, and science communicator whose work bridges the gap between exercise science and public health. With a background in integrative physiology and cardiovascular research, Brady brings a rigorous yet accessible perspective to how physical activity shapes human health and longevity.

Brady completed his graduate work at the University of Florida, where he studied the effects of exercise on cardiovascular function and heart rate variability. His research has focused on VO₂ max, endurance physiology, and how training adaptations influence markers of healthspan and disease risk. He has also contributed to the translation of complex scientific findings into meaningful strategies for improving performance and long-term well-being.

Beyond the lab, Brady is a well-known writer and podcaster, hosting the Science & Chill podcast and contributing to platforms like Examine.com. Through his clear and evidence-based communication, Brady empowers both lay audiences and professionals to better understand the profound impact of movement and exercise on health throughout the lifespan.

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Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they interview Dr. Richard Miller, a distinguished physician-scientist and one of the most influential figures in aging research. As a Professor of Pathology at the University of Michigan and Director of the Paul F. Glenn Center for Aging Research, Dr. Miller has spent decades unraveling the cellular and molecular mechanisms that influence longevity and age-related diseases.

With MD and PhD degrees from Yale University and a career spanning institutions like Harvard, Sloan-Kettering, and Boston University, Dr. Miller brings unmatched depth and insight to the field. His pioneering work focuses on how stress responses, hormones, and nutrients affect the biology of aging, using innovative models and pharmacologic interventions to delay aging and extend healthspan in mice. His research has also explored what sets long-lived species apart, shedding light on how nature’s blueprints can inform human longevity.

A recipient of numerous accolades—including the Nathan Shock Award, the Irving Wright Award, and the Kleemeier Award—Dr. Miller has shaped the landscape of geroscience through editorial leadership, national advisory roles, and groundbreaking studies. His dedication to advancing our understanding of aging has inspired generations of researchers and brought us closer to the possibility of healthier, longer lives.

Find more of Dr. Richard Miller here: https://www.richmillerlab.com/

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Website: https://siciliansecret.com/
Our Book: https://www.amazon.com/Sicilian-Secret-Diet-4-color-trade/dp/189969496X/
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