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  • Cell Signaling, Mitochondria & the Foundation of Cellular Health with Dr. Gus Vickery

    Cell Signaling, Mitochondria & the Foundation of Cellular Health with Dr. Gus Vickery
    2026/08/22
    Cell Signaling, Mitochondria & the Foundation of Cellular Health with Dr. Gus VickeryWhat if the reason you feel tired, foggy, inflamed, or simply not quite like yourself begins much deeper than you think—at the level of your cells?In this episode of The Healthy CEO, Jason Wright welcomes back physician and Authentic Health co-founder Dr. Gus Vickery for a deep dive into one of the most fundamental—and often overlooked—components of health: cell signaling.Our cells aren't isolated little machines. They're constantly communicating with one another, responding to nutrients, hormones, inflammation, stress, toxins, the nervous system, and even our thoughts and environment. When those signals are clear and the cellular machinery is functioning properly, the body can adapt and perform remarkably well.But when those signaling pathways become disrupted, the effects can show up everywhere.Dr. Vickery explains how impaired cellular function can manifest as fatigue, brain fog, inflammation, anxiety, poor sleep, reduced cognitive performance, aches and pains, and diminished energy—sometimes long before someone develops a diagnosable disease.Jason and Gus also explore the crucial role of the mitochondria, the energy-producing structures inside our cells. Using the analogy of a car and its engine, they break down why mitochondrial efficiency isn't simply about producing more energy. The health and integrity of mitochondrial membranes can profoundly influence how effectively that energy-production system operates.The conversation then moves to another overlooked part of cellular health: the cell membrane.Rather than simply being a protective wall around a cell, the membrane is an active participant in communication and signaling. Its composition—including omega-3 fatty acids, phospholipids and other nutrients—can influence membrane fluidity, inflammatory signaling and cellular function.Dr. Vickery explains how testing can reveal imbalances in membrane composition, including low omega-3 levels, elevated saturated fats and deficiencies in important phospholipids. He also discusses why lifestyle and environmental factors appear to play such an important role in mitochondrial dysfunction, even when genetics influence an individual's underlying resilience.The episode concludes with the origin story behind Authentic Health's F2 formulation. Gus explains how years of clinical experience led him from simply supplementing omega-3s to thinking more comprehensively about phospholipids, fat-soluble nutrients, CoQ10 and the other components necessary to support membrane and mitochondrial health.The result was an attempt to simplify what had previously required numerous individual supplements into a more integrated foundational approach.In This EpisodeWhat cell signaling actually means and why it mattersHow cells communicate within tissues and throughout the bodyWhy disrupted signaling may appear as fatigue, brain fog, inflammation and poor moodThe difference between dysfunction and diseaseWhy mitochondrial dysfunction can occur before diagnosable diseaseThe "car engine" analogy for understanding mitochondrial healthWhy mitochondrial membranes are critical to energy productionHow damaged or dysfunctional membranes may reduce mitochondrial efficiencyWhy the cell membrane is much more than a protective shellUnderstanding membrane fluidityThe role of omega-3 fatty acids, including EPA and DHAWhy phospholipids such as phosphatidylcholine matterHow saturated fats and fatty-acid composition affect membrane structureGenetics vs. lifestyle in mitochondrial dysfunctionHow Dr. Vickery evaluates mitochondrial and cellular healthThe difference between conventional primary care and a more integrative diagnostic approachWhy nutrient insufficiency can exist even before obvious deficiency or diseaseThe importance of reducing harmful exposures while restoring essential nutrientsHow Gus's clinical protocol evolved into the F2 essential fats formulationWhy rebuilding cellular and mitochondrial health should be viewed as a long-term process rather than a quick fixKey TakeawayHealth doesn't begin with treating disease. It begins with giving the body what it needs to communicate, produce energy, repair itself and adapt appropriately.As Dr. Vickery explains, dysfunction can exist long before a physician can put a diagnostic label on it. Addressing foundational cellular health earlier may offer an opportunity to support better function before dysfunction becomes more deeply established.And that means thinking beyond symptoms and asking a more fundamental question:What do my cells actually need to function the way they were designed to function?About Dr. Gus VickeryDr. Gus Vickery is a physician with decades of clinical experience whose work has evolved from traditional primary care toward an integrative, precision-health approach focused on understanding and addressing the underlying drivers of dysfunction.His clinical experience and research...
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    57 分
  • Greasing the Groove: The Smarter Way to Build Strength as You Age

    Greasing the Groove: The Smarter Way to Build Strength as You Age
    2026/08/21
    Greasing the Groove: The Smarter Way to Build Strength as You AgeWhat if getting stronger didn’t require crushing yourself in the gym?In this episode of The Healthy CEO, Jason Wright kicks off a new series on strength, muscle, and longevity by exploring one of the most practical strength-training concepts he’s encountered: “Greasing the Groove,” popularized by legendary strength coach Pavel Tsatsouline.As we age, maintaining strength and lean muscle becomes increasingly important—not simply for how we look, but for how well we function. Muscle supports metabolic health, physical resilience, mobility, and our ability to continue doing the things we love as we get older.But building strength doesn’t necessarily mean training to exhaustion.Pavel’s Greasing the Groove philosophy approaches strength differently: treat strength like a skill and practice it frequently without exhausting yourself.Jason breaks down the philosophy before sharing Pavel’s explanation of why frequent, high-quality repetitions can train the nervous system to become more efficient at producing strength.In This EpisodeWhy strength training should be a cornerstone of longevityThe importance of maintaining lean muscle as we ageWhy Jason is placing a greater emphasis on building strengthPavel Tsatsouline’s philosophy of simply getting strongerWhat “Greasing the Groove” actually meansWhy strength can be viewed as a skillThe difference between spaced practice and crammingHow repeated practice strengthens the neural pathways between the brain and musclesWhy you don't need to train to failure to get strongerPavel’s concept of using a weight that is “heavy enough to respect and light enough not to fear”Why Greasing the Groove typically uses only about half the repetitions you could performHow frequent, non-exhaustive strength work can accumulate significant training volumeWhy staying fresh may allow you to practice strength more frequentlyHow to incorporate Greasing the Groove into a normal dayWhy Pavel recommends significant rest between setsThe relationship between strength, practice, skill acquisition, and neurological adaptationWhy the goal is the perfect rep, not simply more repsThe Basic Greasing the Groove ConceptRather than performing a traditional workout where you exhaust a muscle group, Greasing the Groove emphasizes practicing a strength movement repeatedly while remaining relatively fresh.Pavel describes a general approach of:Moderately heavy weight.Low repetitions.High-quality reps.Long rest periods.Frequent practice.Avoiding exhaustion.The objective is to repeatedly practice the movement so the nervous system becomes increasingly efficient at producing it.In Pavel's words, you're essentially “greasing” the neurological groove between your brain and your muscles.Over time, the same movement can require less effort—or you can apply greater force and become stronger.A Practical ExampleIf you could perform approximately eight maximum reps with a given weight, a Greasing the Groove approach might have you perform only three or four high-quality repetitions.Then you stop.You rest.And later, you practice the movement again.Instead of asking:“How hard can I train?”The better question becomes:“How frequently can I practice strength while still staying fresh?”That subtle change in thinking is what makes Greasing the Groove such an interesting approach to building sustainable strength.Jason's TakeawayAs we get older, strength becomes increasingly valuable.This isn't about chasing a bodybuilding physique or spending your life in the gym. It's about creating a body capable of supporting the life you want to live.Jason is experimenting with new ways to increase his own strength and lean body mass, and this episode begins a larger Healthy CEO series exploring the training methods, tools, and strategies that can help us remain strong and capable as we age.The message is simple:Get stronger. Stay strong. And practice strength for life.SponsorThis episode of The Healthy CEO is brought to you by Authentic Health.Explore the Foundational Stack—F1, F2, and F3—at shopauthentichealth.com and use promo code JASON for 10% off.Medical DisclaimerThe content provided in The Healthy CEO is for informational and educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Consult your physician or another qualified healthcare provider before making changes to your exercise, nutrition, supplementation, or health routine.
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    21 分
  • The Root Cause of Addiction & the Path to Your Authentic Self | Pax Prentiss

    The Root Cause of Addiction & the Path to Your Authentic Self | Pax Prentiss
    2026/08/10
    The Root Cause of Addiction & the Path to Your Authentic Self | Pax PrentissWhat if addiction isn't the problem itself—but a symptom of something deeper?On this episode of The Healthy CEO, Jason Wright sits down with Pax Prentiss, co-founder and CEO of Passages Malibu and co-author of The Alcoholism and Addiction Cure.Pax's story is extraordinary. After struggling with heroin, cocaine, and alcohol addiction for nearly a decade, repeated attempts at traditional treatment failed to produce lasting sobriety. Eventually, Pax and his father began asking a different question:Why was he using in the first place?That question changed everything.Rather than focusing exclusively on managing addiction, Pax began addressing the underlying issues driving his substance use. That experience eventually became the foundation for Passages Malibu and its individualized, holistic approach to treatment.Jason and Pax explore addiction, recovery, mental health, family dynamics, physical wellness, and the growing normalization of substances in American culture. But the conversation ultimately becomes something even bigger: How do we stop escaping from our lives and become the healthiest, most authentic versions of ourselves?In This EpisodeJason and Pax discuss:Pax's personal journey from heroin addiction to more than two decades of sobrietyThe question his father asked that changed his recovery: "Why do you think you're using?"Why Pax believes addiction can be a symptom of deeper underlying conditionsDepression, anxiety, trauma, stress, insecurity, low self-esteem, and other factors that can contribute to substance useWhy treating the whole person—body, mind, and spirit—is central to the Passages philosophyHow individualized therapy differs from traditional group-based treatmentWhy escaping uncomfortable emotions can prevent real healingThe importance of confronting problems rather than continually numbing themMarijuana, today's higher-potency products, and Pax's concerns about normalization of recreational drug useKetamine therapy and the addiction cases Pax says he is increasingly encounteringPsychedelic-assisted approaches to trauma and why Pax personally favors clear-headed, individualized therapyHow families can recognize when helping has crossed the line into enablingWhen families should consider working with a professional interventionistWhy recovery doesn't end when someone leaves a treatment centerThe importance of aftercare and creating a healthy home environmentWhy family members may need to change their own relationship with alcohol when someone returns from treatmentThe example parents set for their children around drinking, marijuana, and other substancesWhy Jason and Pax both believe an alcohol-free lifestyle can be transformativeSleep, nutrition, exercise, mental clarity, and their role in rebuilding a healthy lifeIdentity-based habits and becoming the person you actually want to beWhy recovery isn't about creating a new person—it's about rediscovering the person underneath the addictionThe Bigger Idea: Becoming Your Authentic SelfOne of the most powerful themes of the conversation is that recovery isn't simply about removing drugs or alcohol.It's about rebuilding a life.Pax describes a whole-person approach that addresses psychological, physical, relational, and spiritual health. The objective isn't simply sobriety. It's helping someone rediscover who they are without the substance—and begin moving toward the healthiest version of that person.Jason connects this philosophy to his own pursuit of health and personal development: the idea that genuine wellness can't be one-dimensional.Physical health matters.Mental clarity matters.Relationships matter.Purpose matters.Spiritual health matters.And the environments and habits we build around ourselves matter.Ultimately, the goal is not perfection.It's continuing to move toward your authentic self.About Pax PrentissPax Prentiss is the co-founder and CEO of Passages Malibu. His own experience with addiction and recovery inspired the creation of an individualized treatment model focused on identifying and addressing underlying conditions associated with substance use.Passages opened in 2001 and uses a multidisciplinary approach involving medical, clinical, therapeutic, physical, and spiritual components of recovery.Pax is also the co-author of The Alcoholism and Addiction Cure and says Passages has helped more than 40,000 people pursue sobriety and recovery.Need Help?Pax personally continues to speak with individuals and families seeking treatment and takes admission calls for Passages.Passages Admissions: 310-589-2880Passages operates locations in Malibu and Ventura, California. Pax explains in the episode that the Ventura location works in-network with many insurance plans, while insurance may also contribute toward treatment at the Malibu location.If you or someone you love is struggling with substance use, seek qualified professional help. Treatment ...
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    1 時間 9 分
  • Ramona Roemer and Andreas Heigl, Authors of "Unlongevity:

    Ramona Roemer and Andreas Heigl, Authors of "Unlongevity:
    2026/08/10

    Unlongevity: Escaping Optimization Culture With VimedCell Founders Ramona Roemer & Andreas Heigl

    Host Jason Wright interviews Ramona Roemer and Andreas Heigl, co-founders of VimedCell, a longevity clinic in Switzerland and Germany, about their book Unlongevity: Escaping Optimization Culture to Restore Health, Meaning, and a Life That Fits (out August 11).

    They discuss how high-performing clients often overuse biohacking, wearables, supplements, and protocols, creating stress and losing clarity despite heavy effort. Drawing on nearly 20 years of clinical work, they propose an integrative framework across biology, cognition, emotion, energy, and purpose, emphasizing discernment, timing, alignment, and individualized priorities rather than standardized protocols.

    They share an example of a founder whose cognition improved after addressing cortisol dysregulation and reducing stimulants and supplement load. They explain their patient intake process, focus on trust-building and observation, and aim to empower clients with transparent reports for coordination with their own doctors.

    Episode Chapters

    00:00 Welcome and Setup

    00:18 Meet the Guests

    00:24 Optimization Culture Trap

    01:37 Clinic and Book Overview

    02:43 Subscribe and Sponsor

    03:56 Basel Small Talk

    05:03 Why Unlongevity Matters

    07:03 Founders Origin Story

    09:15 Beyond Biology Framework

    12:23 Cognition Under Stress

    13:13 Founder Case Study

    14:57 Five Axes Prioritization

    16:20 Building Trust with Clients

    19:30 Taking Away Protocols

    23:23 Cold Plunge Reality Check

    25:37 Data vs Self Healing

    27:35 Type 1 Diabetes Example

    28:09 Training With Purpose

    29:36 Why Treatments Differ

    32:32 Life Worth Living

    35:03 Clinic Intake Process

    40:11 Testing And Biomarkers

    41:19 Unlongevity Framework

    44:36 Avoid Protocol Overload

    46:51 Awareness Over Tactics

    51:17 Where To Find The Book

    52:53 Wrap Up And Disclaimer
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    54 分
  • Daniel Fabricant, Ph.D. | The Truth About Supplements, FDA Regulation & The Future of Preventive Health

    Daniel Fabricant, Ph.D. | The Truth About Supplements, FDA Regulation & The Future of Preventive Health
    2026/07/20

    Daniel Fabricant, Ph.D. | The Truth About Supplements, FDA Regulation & The Future of Preventive Health

    Episode Summary

    What if everything you've been told about dietary supplements is only part of the story?

    In this episode of The Healthy CEO, Jason Wright sits down with Daniel Fabricant, Ph.D., President and CEO of the Natural Products Association and former Director of Dietary Supplement Programs at the FDA.

    Few people understand both the science and the politics of nutrition better than Dr. Fabricant. Having led dietary supplement regulation inside the FDA before becoming the chief advocate for the natural products industry, he offers a rare, balanced perspective on how supplements are regulated, why misinformation persists, and where preventive healthcare is headed.

    Together, Jason and Daniel discuss why Americans are becoming more proactive about their health, the impact of the MAHA movement, how consumers should evaluate supplement companies, and why physicians and policymakers must begin taking nutrition more seriously.

    Whether you're new to supplements or a lifelong health enthusiast, this conversation will help you become a smarter, more informed healthcare consumer.

    In This Episode
    • Daniel Fabricant's journey from NCAA athlete to FDA regulator to CEO of the Natural Products Association
    • What really happens inside the FDA—and what surprised him most
    • How politics can influence public health policy
    • Lessons learned from COVID-19 and supplement access during the pandemic
    • Why creatine may be the most misunderstood supplement in America
    • Common myths about dietary supplements
    • Why many physicians receive so little nutrition education
    • How to choose supplements backed by science instead of marketing
    • Why consumers should "get brilliant on the basics"
    • The importance of vitamin D, magnesium, zinc, probiotics and foundational nutrition
    • Functional medicine vs. traditional sick care
    • The Make America Healthy Again (MAHA) movement—opportunities and concerns
    • The future of personalized nutrition powered by AI, wearables and biomarker testing
    • How policy in Washington shapes what ultimately ends up in your medicine cabinet

    Memorable Quotes"Get brilliant on the basics.""This isn't a magic bullet industry. It's a lifestyle change industry.""People don't want to surrender their health to the government—they want ownership.""Follow the clinical trials—not the marketing.""Food is finally becoming part of the national healthcare conversation."

    Daniel shares:

    • Favorite coffee style
    • Most underrated supplement (his answer may surprise you)
    • Most overrated supplement
    • One food everyone should eat more often
    • What Americans should dramatically reduce
    • His morning performance routine
    • Leadership habits that keep him healthy while leading one of the nation's most influential health organizations
    • Natural Products Association
    • Authentic Health Foundational Stack
    • Creatine research
    • ClinicalTrials.gov
    • Functional medicine
    • FDA Dietary Supplement Regulations
    • Make America Healthy Again (MAHA)

    Connect with Jason Wright

    If you enjoyed this episode, please subscribe to The Healthy CEO wherever you listen to podcasts.

    Leave a review, share this episode with someone interested in preventive health, and help us spread evidence-based conversations about living healthier while leading at a higher level.

    For more episodes, visit:

    www.TheHealthyCEO.com

    Sponsor

    This episode is brought to you by Authentic Health.

    Close your nutritional gaps with the Authentic Health Foundational Stack, formulated by physicians and designed to support long-term health and performance.

    Visit ShopAuthenticHealth.com

    Use code JASON for 10% off your order.
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    1 時間 5 分
  • All Things Skincare With Dr. Troy Jackson, M.D.

    All Things Skincare With Dr. Troy Jackson, M.D.
    2026/07/03

    Summer Skincare Masterclass: Sunscreen, Retinoids, and Simple Routines with Dr. Troy Jackson Host Jason Wright and Dr. Troy Jackson discuss practical summer skincare focused on sun protection, simple routines, and long-term aging. Jackson explains intrinsic vs. extrinsic skin aging, emphasizing cumulative UV exposure as a primary driver and recommending daily sunscreen on face, ears, and neck, plus reapplication about every two hours (more often with chemical sunscreens or water exposure). He contrasts chemical sunscreens with mineral options like zinc oxide and titanium dioxide, noting mineral products are commonly used for children. They address vitamin D concerns, tanning oils and beds, spray tans, and when to see a dermatologist using the “ugly duckling” mole concept. Jackson outlines a basic routine: gentle cleanser, moisturizer (avoiding fragrances/colorants), morning sunscreen, and nighttime retinoids/retinol with guidance on strength progression. They also cover diet, alcohol’s aging effects, collagen, antioxidants including vitamin C and glutathione, and lifestyle factors like exercise, sauna, recovery, and avoiding extremes. 00:00 Summer Skincare Kickoff 03:01 Why Sunscreen Matters 07:22 Chemical vs Mineral Sunscreens 09:50 Vitamin D vs Sun Protection 11:54 Where to Apply Sunscreen 17:41 Reapplying and Beach Basics 19:04 Tanning Oils and Beds 23:15 Skin Checks and Warning Signs 25:25 Kids Skincare and Social Media 29:43 Simple Routine and Retinoids 32:03 Retinoid Dermatitis Tips 33:16 Budget Skincare Basics 35:18 Gentle Cleansing Rules 38:09 Moisturizers and Irritants 40:59 Retinoids by Age 43:24 Collagen Facts and Food 46:36 Diet for Better Skin 48:42 Alcohol and Skin Aging 50:21 Glutathione Explained 53:18 Sweat Sauna and Recovery 55:30 Ozempic Face and Extremes 58:44 80 20 Health Mindset 01:00:52 Wrap Up and Resources

    Visit Authentic Health Clinic
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    1 時間 4 分
  • Dr. Will Haas on Cellular Health: Toxins, Testing, Foundational Supplements, and Peptides for Healthspan

    Dr. Will Haas on Cellular Health: Toxins, Testing, Foundational Supplements, and Peptides for Healthspan
    2026/06/29

    Dr. Will Haas on Cellular Health: Toxins, Testing, Foundational Supplements, and Peptides for Healthspan Jason interviews Dr. Will Haas about why he chose integrative/functional medicine after realizing medical school focused on “sick care” rather than health optimization, a passion rooted in his youth and athletic background and influenced by mentor Andrew Weil’s view that it’s simply “good medicine.” Haas explains his clinical approach starts with lifestyle foundations (sleep, nutrition, stress, social connection) plus targeted diagnostics, listening for cellular dysfunction patterns like mitochondrial energy deficits that can present as brain fog or fatigue. He emphasizes toxins (including mold/mycotoxins), gut-driven inflammation/dysbiosis, and immune dysregulation as key disruptors, advocating “test, don’t guess” before interventions. They discuss practical basics like hydration, personalized nutrition, common supplementation deficiencies he sees (magnesium, vitamin D, B12/folate, vitamin C, omega-3s), and a cautious, mechanism-based view of peptides, highlighting GLP-1s’ early impact and epitalon’s potential role in optimization and circadian rhythm support. Haas shares his own routine and directs listeners to Vyve Wellness for a discovery call. 00:00 Chasing Performance Inputs 00:21 Why Integrative Medicine 01:28 Meet Dr Will Haas 02:40 Olympics Spark Origin Story 05:14 Healthcare Versus Sick Care 07:18 First Patient Assessment Basics 10:27 Cellular Patterns Not Labels 13:44 Brain Fog Wake Up Call 15:33 Toxins Gut And Mold 21:00 Test Before You Detox 23:16 Food Hydration Personalization 27:38 Dark Chocolate Heavy Metals 28:22 Fiber Goop Breakdown 31:24 Gut Health Reality Check 33:00 Avoiding Optimization Burnout 33:46 Supplements Need Data 36:07 Common Deficiencies Explained 39:16 Antioxidants Need Balance 40:35 Peptides Primer and Hype 42:08 Evidence Based Peptide Lens 44:50 GLP1s Sparked Interest 48:47 Peptides by Pathway Not Stacks 50:22 Epitalon and Circadian Reset 51:30 Older Patients and Root Causes 54:10 Doctor Daily Routine 57:05 Training Mindset and Stress 58:27 Wrap Up and How to Work Together 01:00:46 Sponsor Message and Disclaimer
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    1 時間 3 分
  • Dylan Livingston, Founder Alliance For Longevity Initiatives on Longevity Policy, Right to Try, and Scaling the Longevity Dividend

    Dylan Livingston, Founder Alliance For Longevity Initiatives on Longevity Policy, Right to Try, and Scaling the Longevity Dividend
    2026/06/12

    Dylan Livingston on Longevity Policy, Right to Try, and Scaling the Longevity Dividend Jason Wright interviews Dylan Livingston, founder of the Alliance for Longevity Initiatives (A4LI), about advancing longevity through policy rather than products. Livingston traces his interest from discovering Aubrey de Grey as a teen to COVID-era experiences with his grandfather, which renewed his focus and led him to launch A4LI in 2022 as a coalition of longevity biotech companies. He describes passing a California resolution prioritizing longevity and healthy aging, framing the goal as achieving a “longevity dividend” worth trillions through reduced healthcare costs and increased productivity, and argues therapeutics can democratize longevity more than intensive lifestyle protocols. They discuss Right to Try, its limits under terminal-only access and liability concerns, and A4LI’s work expanding access in Montana and New Hampshire for Phase 1-safe therapies. Livingston highlights AI-driven acceleration in biotech, cellular reprogramming with Yamanaka factors, and previews A4LI’s Georgetown DC summit featuring major companies, researchers, policymakers, and a Capitol Hill briefing on US-China biotech competition. 00:00 Cold Open Banter 01:05 Why Longevity Policy 02:17 Dylan Origin Story 05:39 Launching The Alliance 08:24 Sponsor Message 09:18 California Policy Playbook 10:49 Longevity Dividend Explained 12:39 Therapeutics As Equalizer 13:44 Moral Case For Healthspan 17:48 Right To Try Primer 21:17 Fixing Right To Try 22:23 Biotech Valley Of Death 25:22 AI And Medical Gatekeeping 26:01 AI Health Coach Teaser 26:35 Plan Aware Health Coaching 27:31 Longevity Goals And Motivation 29:38 AI Accelerating Biotech 32:10 Cell Reprogramming Breakthroughs 34:32 Aging As Root Cause Policy 37:10 Wellness Mindset And Agency 40:15 Prevention Limits And Lifelong Care 44:33 DC Summit Agenda Preview 46:24 Hill Briefing And Biotech Race 49:20 Wrap Up And Medical Disclaimer
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    52 分