Can digestive enzymes help with IBS symptoms? What about enzymes that target specific FODMAPs?

In this episode of The Gut Show, we're talking with Jocelyn Wells from FODZYME about digestive enzymes and their role in breaking down FODMAPs.

We'll explore what digestive enzymes are, how they work, and how targeted enzyme therapy may help with digestion and IBS symptoms.

We'll take a closer look at enzymes designed to target specific FODMAPs, discuss whether using an enzyme supplement means you're actually deficient in that enzyme, and whether enzyme therapy can be effective when it doesn't target every FODMAP group.

If you're a clinician wanting FODZYME samples and resources for your practice, you can request them here.

In this episode, we cover:

Behind the scenes [1:53]

Today's guest [3:35]

What are enzymes? [4:39]

What are the different types of enzymes? [6:14]

If an enzyme works, does that mean you are deficient? [10:59]

Targeted enzyme therapy [17:57]

Specific enzymes for the different FODMAPs [22:07]

Inulinase [23:40]

How do these enzymes work? [28:24]

Is it a bad thing to not have that fermentation process? [31:18]

Does it actually work if it doesn't target all of the groups? [34:31]

Can we bypass this and just put these microbes in the gut? [40:28]

Access to dietitian team [43:42]

Have your provider request free samples for their office [47:32]

What's coming up this season [50:05]

Mentioned in this episode:

What's your poop personality?

MASTER Method Membership

Clinicians can request free FODZYME samples for patients at providers.fodzyme.com/hcp-sample-request

Customers can save 20% off your first FODZYME subscription order at fodzyme.com/foodfreedom

About our guest:

Jocelyn Wells, MS, RDN, CSDH, is a Registered Dietitian specializing in gastrointestinal nutrition. She holds a BA from Duke University and an MS in Clinical Nutrition from New York University.

She currently leads clinical strategy and partnerships at FODZYME, a digestive enzyme for FODMAP intolerance, where she oversees HCP education, clinical research, sales, nutrition communications, and professional collaborations. Her work focuses on advancing evidence-based nutrition care to improve patient outcomes and quality of life.

Thank you to our partner:

If you're dealing with GI issues like IBS, SIBO, EoE, IBD, or IMO, you may have heard of the elemental diet.

mBIOTA Elemental is a clinically proven, short-term liquid nutrition protocol that provides essential nutrients in their simplest forms, allowing much of the GI tract to rest and reset. It's a nutrition-based alternative to antibiotics for managing GI conditions.

Developed by a patient and her doctors to improve the patient experience — without sacrificing effectiveness.

Learn more at mBIOTA.com and save 15% on the two-week protocol with code GUTSHOW15.

Connect with Erin Judge, RD:

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TikTok

Work with Erin

FREE symptom tracker

You may have seen Bryan Johnson talking about autoimmune gastritis (AIG), but what is it actually, and what does the research say?

In this episode of The Gut Show, we're digging into autoimmune gastritis, including what happens in the stomach, symptoms, pernicious anemia, and what treatment actually looks like. We'll also take a closer look at some of the claims being shared online and separate what's backed by research from what might be getting a little ahead of the science.

If Bryan Johnson's story has you wondering about AIG or questioning whether you should be worried about it, this episode will help you understand what we actually know.

Mentioned in this episode:

MASTER Method Membership

What's your poop personality?

Thank you to our partner:

If you're dealing with GI issues like IBS, SIBO, EoE, IBD, or IMO, you may have heard of the elemental diet.

mBIOTA Elemental is a clinically proven, short-term liquid nutrition protocol that provides essential nutrients in their simplest forms, allowing much of the GI tract to rest and reset. It's a nutrition-based alternative to antibiotics for managing GI conditions.

Developed by a patient and her doctors to improve the patient experience — without sacrificing effectiveness.

Learn more at mBIOTA.com and save 15% on the two-week protocol with code GUTSHOW15.

Connect with Erin Judge, RD:

Instagram

TikTok

Work with Erin

FREE symptom tracker

Have you ever seen "redundant colon" on your colonoscopy report and wondered what it actually means, or whether it could explain your chronic constipation?

In this episode of The Gut Show, I'm joined by Dr. Kyle Staller to unpack what a redundant colon actually is and, more importantly, whether it matters for your symptoms. We talk about what's considered a "normal" colon length, differences between men and women, and whether the extra twists and loops associated with a redundant colon are something to worry about.

We also get into some of the biggest questions for people struggling with chronic constipation:

• Could a redundant colon be part of the reason stool just doesn't seem to move?

• Is there a connection between redundant colon and hypermobility?

• How does this affect constipation and motility?

About our guest:

Kyle Staller, MD, MPH is a gastroenterologist, Section Chief of Neurogastroenterology and Motility, director of the Gastrointestinal Motility Laboratory at Massachusetts General Hospital, and an Associate Professor of Medicine at Harvard Medical School. Dr. Staller specializes in disorders of gastrointestinal motility and neurogastroenterology and his clinical practice is devoted to treating patients with GI motility disorders and disorders of brain-gut interaction.

Dr. Staller's research interests include clinical and epidemiologic research in neurogastroenterology and motility with particular interest in chronic constipation, irritable bowel syndrome (IBS), fecal incontinence, eating disorders, and women's health in functional GI diseases. His research has been published in medical journals across the spectrum of GI, and he also serves as a medical liaison to the media with appearances in national news outlets as well as health and wellness magazines.

Dr. Staller received his medical degree from Harvard Medical School and trained at Massachusetts General Hospital (MGH) for residency and gastroenterology (GI) fellowship. He also completed formal training in epidemiology culminating in a Masters of Public Health from the Harvard School of Public Health and subspecialty training in neurogastroenterology and motility at MGH before joining the faculty.

Thank you to our partner:

If you're dealing with GI issues like IBS, SIBO, EoE, IBD, or IMO, you may have heard of the elemental diet.

mBIOTA Elemental is a clinically proven, short-term liquid nutrition protocol that provides essential nutrients in their simplest forms, allowing much of the GI tract to rest and reset. It's a nutrition-based alternative to antibiotics for managing GI conditions.

Developed by a patient and her doctors to improve the patient experience — without sacrificing effectiveness.

Learn more at mBIOTA.com and save 15% on the two-week protocol with code GUTSHOW15.

• What is histamine and is it a bad thing?
• What are mast cells?
• How can this affect IBS?
• What does research show?
• Can you test for histamine intolerance?
• Can a low FODMAP diet help?

Mentioned in this episode:

FREE IBS Warrior Summit

MASTER Method Membership

Take the quiz: What's your poop personality?

Mast Cells and MCAS with Dr. Zachary Spiritos