Welcome to episode 35 of the Performance Around the Clock podcast. We’re joined by Dr. Hemal Patel, a distinguished Professor and Vice-Chair for Research in the Department of Anesthesiology at the University of California, San Diego (UCSD) and a VA Research Career Scientist. Holding a Ph.D. in Pharmacology and Toxicology, Dr. Patel's extensive research career has focused on caveolin and mitochondrial biology. In this episode, he discusses the critical role of cell membranes and mitochondria in cellular energy and disease, highlighting how his lab developed a non-invasive blood-based assay for mitochondrial function. This innovative assay, developed through the NASA Twin Study, can assess overall energetic health and disease states without invasive biopsies. Dr. Patel also shares his work on the therapeutic potential of the protein caveolin in conditions like heart disease and neurodegeneration (ALS, Alzheimer's, Parkinson's), and how his recent research has expanded to explore the mind-body connection through the transformative work of Dr. Joe Dispenza. We also talk about how his longtime interest in philosophy and religion has influenced his life and career. Please join us for an wonderful conversion between Dr. Panda and Dr. Patel. If you like this episode, please like, comment or follow. Thanks for listening.

Guest:

Dr. Hemal Patel

Professor and Vice-Chair Department of Anesthesiology, UC San Diego School of Medicine

VA Research Career Scientist

Profile:https://clre.ucsd.edu/faculty/hemal-patel/

Instagram:@hemalpatelphd

https://www.instagram.com/@hemalpatelphd

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Welcome to episode 34 of the Performance Around the Clock. In this episode, host Dr. Satchin Panda, welcomes his esteemed colleague, Dr. Pamela Maher from the Salk Institute for Biological Studies. Dr. Maher is a rare scientist who has taken drug discovery from basic science findings in cells all the way to compounds being tested in human clinical trials. In this episode, they discuss her journey through research on cell membranes and signaling, leading to her pivotal work on cell death pathways like oxytosis and ferroptosis. The conversation also covers the development of potential therapeutics for aging and Alzheimer's disease, including compounds like J147 and CMS-121, and the exploration of cannabinoids for neuroprotection. If you like this episode, please like, comment or follow. Thank you for listening.

Guest:

Dr. Pamela Maher

Research Professor at the Salk Institute

Cellular Neurobiology Laboratory

Profile:

https://www.salk.edu/scientist/pamela-maher/

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Welcome to the Performance Around the Clock podcast. In this episode, Dr. Satchin Panda welcomes one of his scientific heroes, Dr. Susan Golden. Dr. Golden is a pillar in the circadian and cyanobacteria science community and the former director for the Center for Circadian Biology at UC San Diego. She shares her journey from studying gene regulation in cyanobacteria to understanding the circadian clock through this unique organism. Learn how these ancient blue-green algae were instrumental in the oxygenation of Earth's atmosphere and how tools developed to study cyanobacteria led to groundbreaking discoveries. Beyond her research, Dr. Golden also made significant contributions to circadian rhythm education, teaching countless undergraduate students over the years. If you like this episode, please like, comment or subscribe. Thank you for listening.

Guest:

Dr. Susan Golden

Director, Center for Circadian Biology

Chancellor's Associates Chair (III) in Molecular Biology

Distinguished Professor

X (Twitter): @susanksgolden

https://x.com/susanksgolden

Profile:

UCSD:

https://biology.ucsd.edu/research/faculty/sgolden

Wikipedia:

https://en.wikipedia.org/wiki/Susan_Golden

Paper:

Circadian orchestration of gene expression in cyanobacteria

https://pubmed.ncbi.nlm.nih.gov/7601351/

Thanks to 理philosophia onlineについて for the photo of Dr. Takao Kondo

https://www.philosophia.sci.nagoya-u.ac.jp/snapshots/44.html

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/