🎙️ Pathognomia Podcast:

Metabolic Syndrome is not just a cluster of risk factors — it’s a silent global epidemic reshaping modern healthcare. In this in-depth episode of the Pathognomia Podcast, we unpack every critical dimension of this syndrome, guided by authoritative references from Harrison’s Principles of Internal Medicine (22nd Edition) and UpToDate.

🔍 What we cover:

Definition & Evolution – how the concept of metabolic syndrome has changed over decades.

Epidemiology – global burden and special focus on prevalence in the Indian subcontinent.

Pathophysiology – insulin resistance, adipokine imbalance, inflammation, endothelial dysfunction, and even the role of the microbiome.

Diagnostic Criteria – ATP III, IDF, WHO, AHA/NHLBI — compared head-to-head with practical clinical implications.

Clinical Spectrum & Comorbidities – cardiovascular disease, T2DM, NAFLD, CKD, sleep apnea.

Investigations – essential clinical, biochemical, and imaging workup.

Management – from lifestyle modification (diet, exercise, sleep, weight loss) to pharmacotherapy (statins, antihypertensives, metformin, GLP-1RA, SGLT2i), and advanced options like bariatric surgery.

Recent Advances – genetics, precision medicine, microbiome research, emerging therapies.

Controversies – limitations in diagnostic definitions and ongoing debates.

Public Health & Prevention – challenges in screening, healthcare resource allocation, and the role of primary prevention in developing nations.

Ethical Issues – patient communication, stigma, and balancing preventive vs. pharmacological approaches.

Clinical Pearls – practical takeaways for OPD, ICU, and ward-based care.

Delivered in an engaging AI based audio content, case-based conversational style, this episode bridges classical fundamentals with cutting-edge updates, designed especially for postgraduate residents, internists, and clinicians preparing for exams.

✨ By the end of this episode, you won’t just know metabolic syndrome — you’ll know how to recognize, investigate, manage, and contextualize it in everyday clinical practice.

🎙️ Pathognomia Podcast – Sepsis & Septic Shock

Sepsis is not just an ICU diagnosis — it’s one of the deadliest syndromes in medicine. In this episode, we take you to the emergency room: a patient with fever, hypotension, tachypnea, and altered mentation. From there, we journey into the science, signs, and management of sepsis, weaving together Harrison’s Principles of Internal Medicine, 22nd Edition with the latest Surviving Sepsis Campaign Guidelines (2021, reaffirmed 2024).

What you’ll hear:

The evolution from SIRS to Sepsis-3

How dysregulated immunity, endothelial injury, and metabolic collapse drive shock

Clinical features across organ systems — from encephalopathy to purpura fulminans

Modern diagnosis with SOFA, qSOFA, NEWS2, lactate, and biomarkers

Management pearls: Hour-1 bundle, fluids, vasopressors, antimicrobials, source control, adjunctive therapies

Landmark trials that shaped today’s practice

Future directions in sepsis care: phenotyping, immunotherapy, and AI

This isn’t a quick summary. It’s a deep dive — vivid, clinical, and evidence-based — crafted for doctors, residents, and medical students who want to integrate science into bedside reasoning.

Disclaimer:

This podcast is AI-generated audio content, created from authentic, evidence-based medical sources including Harrison 22nd Edition and the Surviving Sepsis Campaign Guidelines. It is for educational purposes only and not a substitute for professional medical advice.

Welcome to Pathognomia Podcast 🎙️ — where we decode complex guidelines into practical bedside wisdom.

In this episode, we take a deep dive into the GINA 2025 Asthma Guidelines, exploring what every clinician, resident, and student must know. From the paradigm-shifting “no SABA-only” approach to practical stepwise therapy, this episode breaks down the science, evidence, and real-world implications of modern asthma management.

We’ll cover:

Why SABA monotherapy is no longer recommended 🚫

The role of ICS-formoterol as both reliever and controller

Updated stepwise management across mild to severe asthma

Special situations: pediatrics, elderly, comorbidities, and pregnancy

Key trial evidence (SYGMA, Novel START, PRACTICAL) shaping these changes.

How to implement GINA 2025 in OPD, ER, and ICU practice

Whether you’re preparing for exams, polishing your clinical acumen, or simply keeping up-to-date with global respiratory standards — this episode will give you clarity, confidence, and clinically actionable knowledge.

Disclaimer:

This podcast is Al-generated audio discussion, created from authentic, evidence-based medical sources. It is intended for healthcare professionals and medical students for educational purposes only. Always verify with official guidelines and clinical judgment. This is not a substitute for professional medical advice.