🎙️ Pathognomia Podcast:

Metabolic Syndrome is not just a cluster of risk factors — it’s a silent global epidemic reshaping modern healthcare. In this in-depth episode of the Pathognomia Podcast, we unpack every critical dimension of this syndrome, guided by authoritative references from Harrison’s Principles of Internal Medicine (22nd Edition) and UpToDate.

🔍 What we cover:

Definition & Evolution – how the concept of metabolic syndrome has changed over decades.

Epidemiology – global burden and special focus on prevalence in the Indian subcontinent.

Pathophysiology – insulin resistance, adipokine imbalance, inflammation, endothelial dysfunction, and even the role of the microbiome.

Diagnostic Criteria – ATP III, IDF, WHO, AHA/NHLBI — compared head-to-head with practical clinical implications.

Clinical Spectrum & Comorbidities – cardiovascular disease, T2DM, NAFLD, CKD, sleep apnea.

Investigations – essential clinical, biochemical, and imaging workup.

Management – from lifestyle modification (diet, exercise, sleep, weight loss) to pharmacotherapy (statins, antihypertensives, metformin, GLP-1RA, SGLT2i), and advanced options like bariatric surgery.

Recent Advances – genetics, precision medicine, microbiome research, emerging therapies.

Controversies – limitations in diagnostic definitions and ongoing debates.

Public Health & Prevention – challenges in screening, healthcare resource allocation, and the role of primary prevention in developing nations.

Ethical Issues – patient communication, stigma, and balancing preventive vs. pharmacological approaches.

Clinical Pearls – practical takeaways for OPD, ICU, and ward-based care.

Delivered in an engaging AI based audio content, case-based conversational style, this episode bridges classical fundamentals with cutting-edge updates, designed especially for postgraduate residents, internists, and clinicians preparing for exams.

✨ By the end of this episode, you won’t just know metabolic syndrome — you’ll know how to recognize, investigate, manage, and contextualize it in everyday clinical practice.