In this episode of Investigating HLH, Adam Narloch speaks with Dr Daniella Schwartz and Dr Randy Cron to discuss a rare, potentially fatal syndrome characterized by hyperinflammation⎯macrophage activation syndrome (MAS). Dr Daniella Schwartz is a rheumatologist in Pittsburgh, Pennsylvania, and is affiliated with the University of Pittsburgh Medical Center (UPMC) Presbyterian Shadyside and the UPMC Magee-Womens Hospital. Dr Randy Cron is a pediatric rheumatologist at Children’s Hospital of Alabama at the University of Alabama (UAB). Hear from these 2 experts about MAS⎯a subtype of hemophagocytic lymphohistiocytosis (HLH) that can occur in rheumatic diseases such as SAll's disease, including systemic juvenile idiopathic arthritis (sJIA).

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©2023 Sobi, Inc. All rights reserved. NP-32204 12/23

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Kari Magee speaks with Dr Bethany Verkamp to discuss her recent research on evaluating treatment response to etoposide-based treatment in patients with HLH. Dr Verkamp is a hematology/oncology fellow in the Cancer and Blood Diseases Institute at Cincinnati Children's Hospital. Hear from Dr Verkamp about her research, findings, and important considerations for assessing patient response to first-line etoposide-based HLH therapy.

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©2023 Sobi, Inc. All rights reserved. NP-32204 12/23

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Adam Narloch is joined by Dr. Saara Kaviany and Dr. Blachy J. Dávila Saldaña for a discussion about treating patients with HLH. Dr Kaviany is a pediatric hematologist-oncologist and an assistant professor of pediatrics at University of Chicago Medicine. Dr Saldaña is also a pediatric hematologist-oncologist and an associate professor of pediatrics at George Washington University. Hear from these 2 experts about the overall treatment goals and strategies for patients with HLH.

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©2023 Sobi, Inc. All rights reserved. NP-32204 12/23

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Adam Narloch speaks with Dr Ashish Kumar and Dr Scott Canna to discuss the challenges involved with diagnosing and managing HLH. Dr Kumar is a pediatric hematologist- oncologist, and a director of the Histiocytosis Center at Cincinnati Children's Hospital. Dr Scott Canna is a pediatric rheumatologist and an Assistant Professor of Pediatrics at Children’s Hospital of Philadelphia. Hear from these 2 experts about why a prompt diagnosis is critical for patients with HLH—and why it can be so difficult to achieve.

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©2023 Sobi, Inc. All rights reserved. NP-32204 12/23

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Adam Narloch speaks with Dr Michelle Hermiston to discuss the history of HLH and advances in understanding this rare disease. Dr Hermiston is a pediatric hematologist-oncologist, a bone marrow transplant specialist, and the director of the Pediatric Immunotherapy Program at UCSF Benioff Children’s Hospital. Join us as we start our journey into the world of HLH!

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©2023 Sobi, Inc. All rights reserved. NP-32204 12/23

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In this episode of Investigating HLH, Adam Narloch, a Thought Leader Liaison at Sobi, speaks with Dr Michelle Hermiston to discuss the history of HLH and advances that have been made in understanding this rare disease. Dr Hermiston is a pediatric hematologist-oncologist, a bone marrow transplant specialist, and the director of the Pediatric Immunotherapy Program at UCSF Benioff Children’s Hospital. Join us as we start our journey into the world of HLH!

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Presented by Sobi Inc.

https://www.sobi.com/usa/en

©2023 Sobi, Inc. All rights reserved. NP-32204 12/23

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.