Adam Narloch speaks with Dr Randy Cron and Dr Daniella Schwartz about the pathology of macrophage activation syndrome (MAS), including its pathophysiology and relationship to hemophagocytic lymphohistiocytosis (HLH). This discussion addresses why MAS recognition can be clinically challenging and how clinicians may think about MAS in the context of hyperinflammation and rheumatologic disease.

This video features expert clinician discussion and is intended for US healthcare professionals.

Chapters

0:00 - What Is Macrophage Activation Syndrome (MAS)?

5:21 - MAS as a Form of Hemophagocytic Lymphohistiocytosis (HLH)

10:12 - Clinical Outcomes and Urgency in MAS

11:09 - Relationship Between MAS and HLH

18:02 - Diagnosing MAS: Criteria, Workup, and Differential Diagnosis

25:53 - Key Takeaways for MAS Recognition and Diagnosis

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Presented by Sobi Inc.

https://www.sobi.com/usa/en

©2023 Sobi, Inc. All rights reserved. NP-32204 12/23

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Kari Magee speaks with Dr Bethany Verkamp to discuss her research on evaluating treatment response to etoposide-based treatment in patients with hemophagocytic lymphohistiocytosis (HLH). The discussion covers clinical and laboratory considerations for monitoring HLH treatment response, including how clinicians may evaluate response over time while managing HLH in patients.

This video features expert clinician discussion and is intended for US healthcare professionals.

Chapters

0:00 - Monitoring Hemophagocytic Lymphohistiocytosis (HLH) Treatment Response: Study Context

2:07 - Study Design: Evaluating HLH Treatment Response

9:19 - Clinical and Laboratory Response Findings in HLH

11:37 - How HCPs May Monitor Treatment Response in HLH

13:53 - Key Takeaways for HLH Response Monitoring

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Presented by Sobi Inc.

https://www.sobi.com/usa/en

©2023 Sobi, Inc. All rights reserved. NP-32204 12/23

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Adam Narloch speaks with Dr Michelle Hermiston to discuss the history of hemophagocytic lymphohistiocytosis (HLH), advances in clinical understanding, and why recognition of this rare hyperinflammatory syndrome remains important. Topics include HLH disease awareness, primary and secondary HLH context, clinical recognition, and the evolving understanding of HLH as a serious hyperinflammatory condition.

This video features expert clinician discussion and is intended for US healthcare professionals.

Chapters

0:00 - What Is Hemophagocytic Lymphohistiocytosis (HLH)?

2:19 - How Clinical Understanding of HLH Has Evolved

6:46 - Immune Dysregulation and Hyperinflammation in HLH

10:16 - Interferon Gamma (IFNγ) and Proinflammatory Cytokines in HLH

14:29 - Primary vs Secondary Hemophagocytic Lymphohistiocytosis (HLH)

21:00 - Key Takeaways for HLH Recognition

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Presented by Sobi Inc.

https://www.sobi.com/usa/en

©2023 Sobi, Inc. All rights reserved. NP-32204 12/23

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Dr Saara Kaviany and Dr Blachy J. Dávila Saldaña discuss the overall treatment goals and management strategies for patients with hemophagocytic lymphohistiocytosis (HLH). The discussion focuses on clinical considerations in HLH management, treatment goals, and factors clinicians may consider when evaluating patients with HLH.

This video features expert clinician discussion and is intended for US healthcare professionals.

Chapters

0:00 - HLH Treatment Goals and Management Overview

5:07 - Primary HLH Treatment Goals: Stabilization, Toxicity Reduction, and HSCT Preparation

10:40 - HSCT in Primary HLH: Treatment Pathway Considerations

18:43 - Initial HLH Treatment and Hyperinflammation Control

24:59 - HLH Treatment Risks and Clinical Considerations

30:01 - Targeted Treatment Approaches in HLH

35:17 - Key Takeaways for HLH Treatment Planning

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Presented by Sobi Inc.

www.sobi.com

©2023 Sobi, Inc. All rights reserved. NP-32204 12/23

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Adam Narloch speaks with Dr Ashish Kumar and Dr Scott Canna to discuss the challenges involved with diagnosing and managing hemophagocytic lymphohistiocytosis (HLH). The discussion focuses on key considerations in HLH management, treatment goals, and clinical complexities involved in evaluating patients with HLH.

This video features expert clinician discussion and is intended for US healthcare professionals.

Chapters

0:00 - Why HLH Diagnosis Can Be Challenging

4:59 - Why Early and Accurate HLH Diagnosis Matters

10:10 - HLH Diagnostic Criteria and Clinical Workup

25:31 - Genetic Testing and Functional Assays for HLH

37:26 - Biomarkers in HLH Diagnosis: Ferritin, sCD25, and CXCL9

43:00 - HLH Disease Mimics and Differential Diagnosis

54:00 - HLH Guidelines: Limitations and Clinical Judgment

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Presented by Sobi Inc.

https://www.sobi.com/usa/en

©2023 Sobi, Inc. All rights reserved. NP-32204 12/23

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In this episode of Investigating HLH, Adam Narloch, a Thought Leader Liaison at Sobi, speaks with Dr Michelle Hermiston to discuss the history of HLH and advances that have been made in understanding this rare disease. Dr Hermiston is a pediatric hematologist-oncologist, a bone marrow transplant specialist, and the director of the Pediatric Immunotherapy Program at UCSF Benioff Children’s Hospital. Join us as we start our journey into the world of HLH!

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Presented by Sobi Inc.

https://www.sobi.com/usa/en

©2023 Sobi, Inc. All rights reserved. NP-32204 12/23

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.