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We were LIVE from the CHEST Annual Meeting 2025! Thanks to everyone who came out and stuck around to chat afterwards. We cover a lot of ground including some conference and Chicago related banter (~8 minutes if you wanted to skip to the learning!)

High frequency oscillation: https://pubmed.ncbi.nlm.nih.gov/40983167/

MELLOW: https://pubmed.ncbi.nlm.nih.gov/39800236/

Continuous glucose monitoring: https://pubmed.ncbi.nlm.nih.gov/39956190/

SAFE-ECMO: https://pubmed.ncbi.nlm.nih.gov/40081660/

BASE: https://pubmed.ncbi.nlm.nih.gov/39971001/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 75! We talk about melatonin! We highlight MELLOW because it has the best acronym (by Burry et al in CHEST 2025). Then we dive into our mailbag!

MELLOW: https://pubmed.ncbi.nlm.nih.gov/39800236/

DEMEL: https://pubmed.ncbi.nlm.nih.gov/40608082/

Meta-analysis: https://pubmed.ncbi.nlm.nih.gov/40662882/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 74! We talk about the history and current practice of SBTs with "Providers Consistently Delay Extubation After Successful Spontaneous Breathing Trials" by Barker et al in Annals of the ATS and the original 1996 SBT article by Ely et al in NEJM.

SBT: https://pubmed.ncbi.nlm.nih.gov/8948561/

SBT (NEJM): https://www.nejm.org/doi/10.1056/NEJM199612193352502

SBT Timing: https://pubmed.ncbi.nlm.nih.gov/40393063/

SBT Timing (Annals ATS): https://www.atsjournals.org/doi/10.1513/AnnalsATS.202502-188OC

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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We are (were) LIVE at ACNP Critical Care Bootcamp 2025! Thank you to the organizers of the conference for inviting us do a live show and thank you to everyone who came out to listen! We talk about the PIC trial or "Adjunctive corticosteroids in non-AIDS patients with severe Pneumocystis jirovecii pneumonia" by Lemiale et al published in the Lancet Respiratory Medicine September 2025

PIC (pubmed): https://pubmed.ncbi.nlm.nih.gov/40652952/
PIC (LRM): https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00125-0/abstract

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 72! We continue talking about the articles from the CCR25 conference with UK-ROX or "Conservative Oxygen Therapy in Mechanically Ventilated Critically Ill Adult Patients" published in JAMA 2025 by Martin et al and TARGET-Protein or "Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit" by Jaber et al in Lancet 2018.

UK-ROX: https://pubmed.ncbi.nlm.nih.gov/40501321/

UK-ROX (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2835384

TARGET-Protein: https://pubmed.ncbi.nlm.nih.gov/40495743/

TARGET-Protein (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2835302

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 71! We continue talking about the articles from the CCR25 conference with FLUID or "A Crossover Trial of Hospital-Wide Lactated Ringer's Solution versus Normal Saline" published in NEJM 2025 by McIntyre et al and our old article is BICAR-ICU or "Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit" by Jaber et al in Lancet 2018.

FLUID: https://pubmed.ncbi.nlm.nih.gov/40503714/

FLUID (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa2416761

BICAR-ICU: https://pubmed.ncbi.nlm.nih.gov/29910040/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 70! In this episode we have a special guest, Wes Ely, join us to talk about A2B or "Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients" by Walsh et al published in JAMA May of 2025. A long discussion but a good one, don't miss this one!

Pubmed: https://pubmed.ncbi.nlm.nih.gov/40388916/

JAMA: https://jamanetwork.com/journals/jama/article-abstract/2834276

Editorial: https://jamanetwork.com/journals/jama/article-abstract/2834277

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 69! We start talking about the articles from the CCR25 conference with RESCUE-3 or "Temporary Transvenous Diaphragm Neurostimulation for Weaning from Mechanical Ventilation" published in AJRCCM by Dres et al and PROMIZING or "Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation" by Bosma et al in NEJM.

RESCUE-3 (pubmed): https://pubmed.ncbi.nlm.nih.gov/40498082/

PROMIZING (pubmed): https://pubmed.ncbi.nlm.nih.gov/40513024/

PROMIZING (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa2505708

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!