『Hart2Heart with Dr. Mike Hart』のカバーアート

Hart2Heart with Dr. Mike Hart

Hart2Heart with Dr. Mike Hart

著者： Dr. Mike Hart
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Hart2Heart is the show where Dr. Mike Hart breaks down evidence-based health, longevity, performance, and modern medicine without the fluff. Each episode explores practical, evidence-based strategies for improving your life, including hormone health, peptides, sleep optimization, nutrition, supplements, exercise, sunlight, psychedelics, and smarter medication use. The goal is simple: help you understand what actually works so you can make better decisions for your health. The show also looks at the bigger picture, including how public health policy and politics influence personal well-being, and what you can do to take back control. If you want clear, actionable, no-BS conversations about living healthier, performing better, and thinking for yourself, this podcast is for you.Copyright 2023 | Upfire Digital LLC 衛生・健康的な生活 身体的病い・疾患
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  • #239 Oral Peptides: How They Work Without Entering the Bloodstream

    #239 Oral Peptides: How They Work Without Entering the Bloodstream
    2026/09/24
    Dr. Mike Hart discusses how oral peptides can still have biological effects despite limited or no systemic absorption, using examples including KPV, BPC-157, linaclotide (Constella), oral semaglutide, and cyclosporine. He explains protein digestion into dipeptides/tripeptides and the PEPT1 transporter that moves some small peptides into enterocytes for local cellular effects, noting that KPV can act in intestinal cells without entering circulation and that carnosine is another PEPT1-absorbed example. He outlines multiple local mechanisms (acting in the gut lumen, on the enterocyte surface, inside enterocytes, and in nearby gut tissue) and contrasts these with systemic absorption examples like semaglutide formulated with SNAC (only 0.4–1% reaches blood yet remains effective) and cyclosporine's unusual properties. He notes exceptions like glutathione and discusses theories for BPC-157's oral effects, emphasizing regulated products and upcoming discussion on GLP-1s and obesity with Dr. Spencer Nadolsky. LINZESS (Linaclotide) Prescribing Information — DailyMed, U.S. National Library of Medicine (dailymed.nlm.nih.gov) https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=linaclotide PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation — Gastroenterology / PubMed, U.S. National Library of Medicine (PubMed) https://pubmed.ncbi.nlm.nih.gov/18061177/ The Oligopeptide Transporter PEPT1 in Human Intestine — PubMed, U.S. National Library of Medicine (PubMed) https://pubmed.ncbi.nlm.nih.gov/9207295/ Oral Semaglutide (RYBELSUS) Prescribing Information — Novo Nordisk / DailyMed, U.S. National Library of Medicine (DailyMed) https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=27f15fac-7d98-4114-a2ec-92494a91da98 Transcellular Stomach Absorption of Oral Semaglutide With SNAC — Science Translational Medicine / PubMed (PubMed) https://pubmed.ncbi.nlm.nih.gov/30429357/ BPC-157 Oral Administration and Gastrointestinal Healing Research — University of Zagreb / PubMed (PubMed) https://pubmed.ncbi.nlm.nih.gov/18818478/ Cyclosporine Oral Prescribing Information — DailyMed, U.S. National Library of Medicine (DailyMed) https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bfca7088-fe93-abb9-3ec3-e6f5710a69c6 Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:52 Oral Peptides Mythbusting 02:37 Protein Digestion Basics 03:31 PEPT1 Absorption Pathway 04:39 KPV and Carnosine Examples 06:12 Glutathione Exception 07:38 Garden Hose Local Actions 08:26 Linaclotide IBS Mechanism 09:37 Four Local Action Sites 11:25 SNAC Enables Blood Levels 13:26 Cyclosporine Oral Exception 14:35 Other Minor Pathways 15:43 BPC 157 Oral Mystery 18:10 Wrap Up and Safety Notes 19:57 Closing and Next Episode The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
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    20 分
  • #238 The Science of Hormones: Birth Control, HRT, and Thyroid with Dr. Masghati

    #238 The Science of Hormones: Birth Control, HRT, and Thyroid with Dr. Masghati
    2026/09/17
    In this episode, Dr. Mike Hart and OB-GYN Dr. Salome Masghati examine how common hormone interventions can affect women far beyond pregnancy prevention or symptom relief. They discuss the risks and tradeoffs of different birth control options, possible effects on mood, libido, testosterone, and attraction, and why individual responses can vary significantly. The conversation then explores when to consider HRT, the roles of estrogen, progesterone, and testosterone, thyroid testing beyond TSH, and how shifting hormones may contribute to mast cell symptoms during perimenopause. The episode provides a practical framework for making more informed and personalized decisions about hormone care. Dr. Salome Masghati is a board-certified OB-GYN and functional gynecologist whose work focuses on individualized hormone care for women throughout their reproductive years, perimenopause, and menopause. Her approach combines symptoms, menstrual patterns, comprehensive laboratory testing, metabolic markers, and treatment response to understand each patient's complete health picture rather than relying on a single test or standardized protocol. She works with bioidentical and rhythmic hormone strategies, thyroid care, sexual wellness, and root-cause assessment, emphasizing informed choices, careful monitoring, and helping patients move beyond temporary symptom control toward better long-term health and function. Dr. Salome Masghati Official Website — Dr. Salome Masghati, Precision Gynecology https://drsalomemasghati.com/ Dr. Salome Masghati on Instagram — Dr. Salome Masghati https://www.instagram.com/drsalomemasghatimd/ This Is Your Brain on Birth Control — Dr. Sarah E. Hill https://www.sarahehill.com/books/your-brain-on-birth-control/ Women's Health Initiative — National Heart, Lung, and Blood Institute, NIH https://www.nhlbi.nih.gov/science/womens-health-initiative-whi 2022 Hormone Therapy Position Statement — The North American Menopause Society https://menopause.org/wp-content/uploads/professional/nams-2022-hormone-therapy-position-statement.pdf Mortality Associated With Hormone Replacement Therapy — Shelley R. Salpeter et al. https://pubmed.ncbi.nlm.nih.gov/15209595/ Oral Contraceptives, SHBG, and Androgen Levels — Claudia Panzer et al. https://pubmed.ncbi.nlm.nih.gov/16409223/ Hormonal Contraceptive Discontinuation and Relationship Satisfaction — V. Michelle Russell et al. https://pubmed.ncbi.nlm.nih.gov/25404285/ Progestogen Use and Intracranial Meningioma Risk — Léa Hoisnard et al., The BMJ https://www.bmj.com/content/384/bmj-2023-078078 Physiologic Hormone Restoration Therapy — Women's Hormone Network https://womenshormonenetwork.org/traditional-versus-pr/ GlycanAge Biological Age Test — GlycanAge https://glycanage.com/ Show Notes 00:00 Welcome to the Hart2Heart Podcast 01:00 Birth Control Safety Overview 02:07 SHBG Testosterone Libido Risks 04:19 SSRIs And Sexual Side Effects 05:26 Depo Shot Meningioma Concerns 09:07 Choosing Alternatives And Counseling 12:40 Attraction Changes And Partner Choice 15:20 Doctor Personal Story Coming Off 19:15 Menopause HRT Fear And WHI 22:00 Estrogen Window For Heart Brain 24:12 HRT Longevity And Start Age 30:41 Testosterone For Women Benefits 33:06 Rhythmic Hormone Dosing Explained 35:30 Cycle-Based GLP-1 Dosing 37:12 Evidence for Rhythmic HRT 39:32 Hormone Cycling and Cancer Risk 41:13 Why Most Doctors Don't 42:58 Libido and Orgasm Tools 46:59 Thyroid Labs Beyond TSH 50:26 Thyroid Antibodies Strategy 54:59 Staying on HRT for Life 58:21 Bioidentical Hormone Choices 01:00:53 Progesterone Delivery Debate 01:02:50 Mast Cell Activation Explained 01:07:28 Wrap-Up and Where to Follow The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that...
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    1 時間 10 分
  • #237 Oral Health, Blood Pressure, and Better Hygiene: Dr. Eilon on Toothpaste, Mouthwash, and Whitening

    #237 Oral Health, Blood Pressure, and Better Hygiene: Dr. Eilon on Toothpaste, Mouthwash, and Whitening
    2026/09/10

    Dr. Mike Hart sits down with Dr. Ilon Choai to unpack everyday dental habits and the connection between oral and overall health. They discuss choosing toothpaste, fluoride versus nano-hydroxyapatite, and how mouthwash may affect the oral microbiome. Dr. Choai shares his approach to brushing, flossing, tongue scraping, and managing dietary acid exposure, while explaining teeth-whitening options, addressing root canal concerns, and outlining what to consider before getting veneers.

    Dr. Ilon Choai is a practicing dentist, the creator of NOBS oral care products, and a co-host of Down to Health. His work emphasizes preventive dentistry, patient education, and helping people build habits they can maintain beyond the dental chair. Known online as @thenobsdentist, he encourages informed conversations about dental products and treatment choices. His approach combines clinical care with an interest in moving dentistry beyond "drill, fill, and bill" toward a more integrated role in whole-body health.

    NOBS Toothpaste Tablets — NOBS
    https://nobsroutines.com/products/nobs-toothpaste-tablets

    NOBS Herbal Mouthwash — NOBS
    https://nobsroutines.com/products/nobs-herbal-mouthwash

    Atomic Habits — James Clear
    https://jamesclear.com/atomic-habits

    Root Canal Discussion: "Is This Procedure Really Causing Cancer?" — Down to Health, featuring Dr. Valerie Kanter
    https://music.youtube.com/podcast/Vn-SH7qbvkw

    Relative Dentin Abrasivity (RDA) Explained — American Dental Association
    https://www.ada.org/resources/ada-library/oral-health-topics/toothpastes

    Show Notes

    00:00 Welcome to the Hart2Heart Podcast

    01:08 Why Oral Health Matters

    04:35 Choosing The Right Toothpaste

    09:15 Why Whitening Toothpaste Fails

    13:58 Key Toothpaste Ingredients

    22:49 Hydroxyapatite And Fluoride

    28:31 Electric Brushes And Technique

    30:56 Waterpik Versus Flossing

    34:32 Mouthwash Myths And Safer Picks

    40:24 Acidic Mouthwash Risks

    41:00 Tongue Scraping Basics

    44:21 Nighttime Snacking Rules

    45:48 Carbonated Drinks and pH

    47:43 Mouth Breathing and Dry Mouth

    50:39 Teeth Whitening Science

    54:00 Whitening Options and Longevity

    01:00:25 Dental Cleaning Ingredients

    01:01:54 Fillings Materials and Safety

    01:06:53 Root Canals Mythbusting

    01:11:34 Veneers Hype and Downsides

    01:16:37 Gum Disease and Heart Health

    01:20:19 Ideal Oral Hygiene Plan

    01:24:10 Where to Find NOBS

    The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance.

    This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary.

    Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.

    Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary

    (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as

    Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).

    If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.

    Connect with Dr. Mike Hart

    Instagram: @drmikehart
    Twitter: @drmikehart
    Facebook: @drmikehart
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    1 時間 25 分
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