In this solo episode, Dr. Mike delves into the complex relationship between dopamine, romantic relationships, and the Coolidge Effect. The discussion highlights why men often feel the need for a new partner due to a desensitization of dopamine and how our overstimulated lifestyles contribute to this issue. The host explores the impact of modern habits on dopamine levels, the importance of boredom for resetting dopamine sensitivity, and the role of anticipation in maintaining desire. Practical solutions like dopamine resets, engaging in effort-based activities, and ensuring personal growth and solitude are discussed as ways to improve both individual well-being and relationship satisfaction.

Links:

Show Notes:

00:00 Welcome back to the Hart2Heart Podcast with Dr. Mike Hart

28:38 "Our nervous system never gets any time to recover—and that kills desire."

—

The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to

cutting through the noise and uncovering the most effective strategies for optimizing health,

longevity, and peak performance. This podcast dives deep into evidence-based approaches to

hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise

protocols, leveraging sunlight light, and de-prescribing pharmaceuticals—using medications only when absolutely necessary.

Beyond health science, we tackle the intersection of public health and politics, exposing how

policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.

Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary

(Commissioner of the Food and Drug Administration (FDA) and high-profile names such as

Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).

If you're ready to take control of your health and performance, this is the podcast for you. We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.

Connect on social with Dr. Mike Hart:

• Instagram: @drmikehart

• Twitter: @drmikehart

• Facebook: @drmikehart

In this episode, Dr. Mike Hart delves into the origins and contemporary relevance of the 10,000 steps rule. He discusses the latest research outcomes from a massive meta-analysis comparing daily step counts from 2,000 to 12,000 steps and their associated health benefits. Listeners will learn about the significant reductions in mortality, cardiovascular disease, cancer mortality, dementia, depression, and type 2 diabetes risk achieved by increasing daily steps. The episode also provides insights into the importance of breaking up sedentary periods, the physiological differences between various forms of steps, and practical tips for incorporating more steps into daily routines, even for office workers.

Links:

Show Notes:

(00:00) Welcome back to the Hart2Heart Podcast with Dr. Mike Hart

(06:34) "Each 1,000 steps lowers your chance of depression by about 9%."

—

The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to

cutting through the noise and uncovering the most effective strategies for optimizing health,

longevity, and peak performance. This podcast dives deep into evidence-based approaches to

hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise

protocols, leveraging sunlight light, and de-prescribing pharmaceuticals—using medications only when absolutely necessary.

Beyond health science, we tackle the intersection of public health and politics, exposing how

policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.

Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary

(Commissioner of the Food and Drug Administration (FDA) and high-profile names such as

Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).

If you're ready to take control of your health and performance, this is the podcast for you. We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.

Connect on social with Dr. Mike Hart:

• Instagram: @drmikehart

• Twitter: @drmikehart

• Facebook: @drmikehart

In this solo episode, the host discusses the effects of metformin, berberine, and dihydroberberine on exercise adaptation and longevity. While metformin is known for its longevity benefits and is popular in the biohacking community, it has been shown to significantly reduce exercise adaptations and VO2 max gains. Berberine, a supplement with similar effects to metformin, is easier to obtain but still has some negative effects on exercise and significant GI side effects. The episode introduces dihydroberberine (DHB), a compound with fewer GI issues and less impact on exercise adaptation, making it more suitable for athletes. The host explains the mechanisms behind these compounds, including their effects on AMPK and mTOR pathways, and offers practical advice on when to take DHB in relation to different types of exercise to maximize benefits and minimize drawbacks.

Links:

Harvard longevity researcher known for NAD+ & aging research.

Diabetes drug often discussed for longevity.
Energy-sensing enzyme that promotes catabolic (fat-burning) pathways.

Show Notes:

00:00 Welcome back to the Hart2Heart Podcast with Dr. Mike Hart

00:14 "Metformin may blunt up to 50% of your VO₂ max gains — that's a massive hit for any athlete."

00:30 Metformin: the popular longevity drug

01:00 Berberine: the over-the-counter alternative

02:30 Understanding AMPK and mTOR

04:30 Metformin's mechanism and drawbacks

06:00 Berberine's mechanism and side effects

07:30 Dihydro berberine: the superior choice

10:30 DHB and exercise: timing and benefits

18:00 Comparing Metformin, berberine, and DHB

—

The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to

cutting through the noise and uncovering the most effective strategies for optimizing health,

longevity, and peak performance. This podcast dives deep into evidence-based approaches to

hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise

protocols, leveraging sunlight light, and de-prescribing pharmaceuticals—using medications only when absolutely necessary.

Beyond health science, we tackle the intersection of public health and politics, exposing how

policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.

Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary

(Commissioner of the Food and Drug Administration (FDA) and high-profile names such as

Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).

If you're ready to take control of your health and performance, this is the podcast for you. We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.

Connect on social with Dr. Mike Hart:

• Instagram: @drmikehart

• Twitter: @drmikehart

• Facebook: @drmikehart

In this episode of the Heart to Heart podcast, Dr. Mike Hart interviews Dr. Corey Peacock, an exercise physiologist and department chair at Nova Southeastern University. Dr. Peacock discusses his diverse background, from establishing the Fight Science Laboratory to working with elite MMA fighters at Kill Cliff Fight Club. The conversation covers advanced training methods, including zone-based cardio, strength and conditioning exercises, and recovery protocols. Listeners gain insights into the importance of athletic balance, the role of power versus strength in MMA, and the efficacy of various recovery tools such as cold plunges, sauna, and red light therapy. Dr. Peacock emphasizes the tailored approach needed for different fighters and the benefits of continually evolving training strategies.

Dr. Corey Peacock is an exercise physiologist, sports scientist, and performance coach who bridges academic research with elite MMA training. He holds a Ph.D. in Exercise Physiology from Kent State University and serves as Department Chair of Health and Human Performance at Nova Southeastern University, where he co-founded the Fight Science Lab. As Director of Athlete Performance for Kill Cliff Fight Club, Dr. Peacock helps world-class fighters optimize strength, endurance, and recovery through science-driven performance methods.

Connect with him on Instagram @drcpeacock and LinkedIn.

Links:

American College of Sports Medicine (ACSM)

Kill Cliff Fight Club (formerly Blackzilians and Sanford MMA)

Dr. José Antonio – Co-founder of Fight Science Lab

Norwegian 4x4 Interval Method

Show Notes:

00:00 Welcome back to the Hart2Heart podcast with Dr. Mike Hart

00:47 Dr. Corey Peacock's Background

02:52 Cardio Training for MMA Fighters

17:41 Strength and Conditioning Essentials

30:35 Reverse Hypers and Posterior Chain Training

34:17 Balancing Strength and Power in MMA

36:44 Training Insights from Anthony Rumble Johnson

42:42 The Role of HRV in Training Adjustments

47:13 Recovery Tools: Cold Plunges, Sauna, and Red Light Therapy

52:57 Upcoming Events and Contact Information

—

The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to

cutting through the noise and uncovering the most effective strategies for optimizing health,

longevity, and peak performance. This podcast dives deep into evidence-based approaches to

hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise

protocols, leveraging sunlight light, and de-prescribing pharmaceuticals—using medications only when absolutely necessary.

Beyond health science, we tackle the intersection of public health and politics, exposing how

Policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.

Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary

(Commissioner of the Food and Drug Administration (FDA) and high-profile names such as

Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).

If you're ready to take control of your health and performance, this is the podcast for you. We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.

Connect on social with Dr. Mike Hart:

• Instagram: @drmikehart

• Twitter: @drmikehart

• Facebook: @drmikehart

In this solo podcast episode, Dr. Mike Hart delves into the intricacies of insulin resistance, a prevalent yet misunderstood condition. The episode covers the fundamental role of insulin, what happens during insulin resistance, and its linkage to various diseases like diabetes and heart disease. It includes a detailed discussion on how to measure insulin resistance using markers like triglyceride to HDL ratio, fasting insulin, fasting glucose, and hemoglobin A1c. Dr. Hart also explains the significance of advanced glycation end products (AGEs) and how they contribute to aging and diabetes. Practical tips on improving insulin sensitivity through diet, exercise, and supplements such as fiber, mulberry leaf extract, and berberine are provided. Additional considerations for managing blood sugar levels and preventing insulin resistance are also discussed.

Links:

Fasting Insulin Test: https://medlineplus.gov/lab-tests/insulin-in-blood/

Fructosamine Test: https://medlineplus.gov/lab-tests/insulin-in-blood/

Carnosine: https://examine.com/supplements/carnosine/?show_conditions=true

P5P (Pyridoxal-5-Phosphate): https://examine.com/supplements/vitamin-b6/?show_conditions=true

Show Notes:

00:00 Welcome back to the Hart2Heart Podcast with Dr. Mike Hart

00:56 Understanding Insulin and Insulin Resistance

03:02 Markers and Tests for Insulin Resistance

11:30 Advanced Glycation End Products (AGEs)

14:16 Exercise and Insulin Sensitivity

14:53 "Exercise keeps your body insulin sensitive for up to 48 hours — not just two."

16:21 Nutritional Strategies for Blood Sugar Control

20:59 Supplements and Medications for Blood Sugar Management

—

The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to

cutting through the noise and uncovering the most effective strategies for optimizing health,

longevity, and peak performance. This podcast dives deep into evidence-based approaches to

hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise

protocols, leveraging sunlight light, and de-prescribing pharmaceuticals—using medications only when absolutely necessary.

Beyond health science, we tackle the intersection of public health and politics, exposing how

policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.

Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary

(Commissioner of the Food and Drug Administration (FDA) and high-profile names such as

Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).

If you're ready to take control of your health and performance, this is the podcast for you. We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.

Connect on social with Dr. Mike Hart:

• Instagram: https://www.instagram.com/drmikehart/

• Twitter: https://twitter.com/drmikehart

• Facebook: https://www.facebook.com/MikeHartEPS/

In this episode, host Dr. Mike Hart welcomes neuroscientist and author Dr. Ben Rein to discuss his new book, 'Why Brains Need Friends: The Neuroscience of Social Connection.' Dr. Rein shares his journey in neuroscience, his research on autism and MDMA, and his pivot towards science communication. They delve into the devastating effects of loneliness, comparing its impact on mortality to smoking 15 cigarettes a day, and explore why human connections are critical for our brain health. Dr. Rein also discusses the benefits of having pets, the intricate balance of social interactions across a lifespan, the effects of MDMA on feelings of connection, and the role of oxytocin in social bonding. This episode provides a deep dive into the science behind social interactions, offering actionable insights to improve mental health and wellbeing.

Dr. Ben Rein is a neuroscientist, educator, and science communicator whose work explores the biology of human connection, empathy, and social behavior. With a Ph.D. in neuroscience and postdoctoral research at Stanford University, Dr. Rein has studied everything from the neural underpinnings of autism spectrum disorder to how MDMA (ecstasy) enhances empathy in the brain.

Follow his work at mindscience.org or connect with him on Instagram.

Links:

• Oxytocin ("the love hormone")

• Loneliness and mortality studies

• Stanford University

• Lion's Mane

Show Notes:

00:00 Welcome back to the Hart2Heart podcast with Dr. Mike Hart

00:30 Dr. Ben Rein's background and new book

02:30 The loneliness epidemic and its effects

04:00 The science behind social interaction

04:15 " Being isolated is worse for you or as bad for you as smoking 15 cigarettes a day."

10:30 Extroversion vs. introversion: social needs

24:00 Oxytocin: the love hormone

33:00 Teamwork and social bonds

36:30 The power of tribalism in sports

38:00 Romantic relationships and health

42:00 The impact of loneliness across a lifetime

49:00 Social media and loneliness

01:02:00 The therapeutic potential of MDMA

—

The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to

cutting through the noise and uncovering the most effective strategies for optimizing health,

longevity, and peak performance. This podcast dives deep into evidence-based approaches to

hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise

protocols, leveraging sunlight light, and de-prescribing pharmaceuticals—using medications only when absolutely necessary.

Beyond health science, we tackle the intersection of public health and politics, exposing how

Policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.

Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary

(Commissioner of the Food and Drug Administration (FDA) and high-profile names such as

Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).

If you're ready to take control of your health and performance, this is the podcast for you. We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.

Connect on social with Dr. Mike Hart:

• Instagram: @drmikehart

• Twitter: @drmikehart

• Facebook: @drmikehart