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  • #238 The Science of Hormones: Birth Control, HRT, and Thyroid with Dr. Masghati

    #238 The Science of Hormones: Birth Control, HRT, and Thyroid with Dr. Masghati
    2026/09/17
    In this episode, Dr. Mike Hart and OB-GYN Dr. Salome Masghati examine how common hormone interventions can affect women far beyond pregnancy prevention or symptom relief. They discuss the risks and tradeoffs of different birth control options, possible effects on mood, libido, testosterone, and attraction, and why individual responses can vary significantly. The conversation then explores when to consider HRT, the roles of estrogen, progesterone, and testosterone, thyroid testing beyond TSH, and how shifting hormones may contribute to mast cell symptoms during perimenopause. The episode provides a practical framework for making more informed and personalized decisions about hormone care. Dr. Salome Masghati is a board-certified OB-GYN and functional gynecologist whose work focuses on individualized hormone care for women throughout their reproductive years, perimenopause, and menopause. Her approach combines symptoms, menstrual patterns, comprehensive laboratory testing, metabolic markers, and treatment response to understand each patient's complete health picture rather than relying on a single test or standardized protocol. She works with bioidentical and rhythmic hormone strategies, thyroid care, sexual wellness, and root-cause assessment, emphasizing informed choices, careful monitoring, and helping patients move beyond temporary symptom control toward better long-term health and function. Dr. Salome Masghati Official Website — Dr. Salome Masghati, Precision Gynecology https://drsalomemasghati.com/ Dr. Salome Masghati on Instagram — Dr. Salome Masghati https://www.instagram.com/drsalomemasghatimd/ This Is Your Brain on Birth Control — Dr. Sarah E. Hill https://www.sarahehill.com/books/your-brain-on-birth-control/ Women's Health Initiative — National Heart, Lung, and Blood Institute, NIH https://www.nhlbi.nih.gov/science/womens-health-initiative-whi 2022 Hormone Therapy Position Statement — The North American Menopause Society https://menopause.org/wp-content/uploads/professional/nams-2022-hormone-therapy-position-statement.pdf Mortality Associated With Hormone Replacement Therapy — Shelley R. Salpeter et al. https://pubmed.ncbi.nlm.nih.gov/15209595/ Oral Contraceptives, SHBG, and Androgen Levels — Claudia Panzer et al. https://pubmed.ncbi.nlm.nih.gov/16409223/ Hormonal Contraceptive Discontinuation and Relationship Satisfaction — V. Michelle Russell et al. https://pubmed.ncbi.nlm.nih.gov/25404285/ Progestogen Use and Intracranial Meningioma Risk — Léa Hoisnard et al., The BMJ https://www.bmj.com/content/384/bmj-2023-078078 Physiologic Hormone Restoration Therapy — Women's Hormone Network https://womenshormonenetwork.org/traditional-versus-pr/ GlycanAge Biological Age Test — GlycanAge https://glycanage.com/ Show Notes 00:00 Welcome to the Hart2Heart Podcast 01:00 Birth Control Safety Overview 02:07 SHBG Testosterone Libido Risks 04:19 SSRIs And Sexual Side Effects 05:26 Depo Shot Meningioma Concerns 09:07 Choosing Alternatives And Counseling 12:40 Attraction Changes And Partner Choice 15:20 Doctor Personal Story Coming Off 19:15 Menopause HRT Fear And WHI 22:00 Estrogen Window For Heart Brain 24:12 HRT Longevity And Start Age 30:41 Testosterone For Women Benefits 33:06 Rhythmic Hormone Dosing Explained 35:30 Cycle-Based GLP-1 Dosing 37:12 Evidence for Rhythmic HRT 39:32 Hormone Cycling and Cancer Risk 41:13 Why Most Doctors Don't 42:58 Libido and Orgasm Tools 46:59 Thyroid Labs Beyond TSH 50:26 Thyroid Antibodies Strategy 54:59 Staying on HRT for Life 58:21 Bioidentical Hormone Choices 01:00:53 Progesterone Delivery Debate 01:02:50 Mast Cell Activation Explained 01:07:28 Wrap-Up and Where to Follow The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that...
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    1 時間 10 分
  • #237 Oral Health, Blood Pressure, and Better Hygiene: Dr. Eilon on Toothpaste, Mouthwash, and Whitening

    #237 Oral Health, Blood Pressure, and Better Hygiene: Dr. Eilon on Toothpaste, Mouthwash, and Whitening
    2026/09/10

    Dr. Mike Hart sits down with Dr. Ilon Choai to unpack everyday dental habits and the connection between oral and overall health. They discuss choosing toothpaste, fluoride versus nano-hydroxyapatite, and how mouthwash may affect the oral microbiome. Dr. Choai shares his approach to brushing, flossing, tongue scraping, and managing dietary acid exposure, while explaining teeth-whitening options, addressing root canal concerns, and outlining what to consider before getting veneers.

    Dr. Ilon Choai is a practicing dentist, the creator of NOBS oral care products, and a co-host of Down to Health. His work emphasizes preventive dentistry, patient education, and helping people build habits they can maintain beyond the dental chair. Known online as @thenobsdentist, he encourages informed conversations about dental products and treatment choices. His approach combines clinical care with an interest in moving dentistry beyond "drill, fill, and bill" toward a more integrated role in whole-body health.

    NOBS Toothpaste Tablets — NOBS
    https://nobsroutines.com/products/nobs-toothpaste-tablets

    NOBS Herbal Mouthwash — NOBS
    https://nobsroutines.com/products/nobs-herbal-mouthwash

    Atomic Habits — James Clear
    https://jamesclear.com/atomic-habits

    Root Canal Discussion: "Is This Procedure Really Causing Cancer?" — Down to Health, featuring Dr. Valerie Kanter
    https://music.youtube.com/podcast/Vn-SH7qbvkw

    Relative Dentin Abrasivity (RDA) Explained — American Dental Association
    https://www.ada.org/resources/ada-library/oral-health-topics/toothpastes

    Show Notes

    00:00 Welcome to the Hart2Heart Podcast

    01:08 Why Oral Health Matters

    04:35 Choosing The Right Toothpaste

    09:15 Why Whitening Toothpaste Fails

    13:58 Key Toothpaste Ingredients

    22:49 Hydroxyapatite And Fluoride

    28:31 Electric Brushes And Technique

    30:56 Waterpik Versus Flossing

    34:32 Mouthwash Myths And Safer Picks

    40:24 Acidic Mouthwash Risks

    41:00 Tongue Scraping Basics

    44:21 Nighttime Snacking Rules

    45:48 Carbonated Drinks and pH

    47:43 Mouth Breathing and Dry Mouth

    50:39 Teeth Whitening Science

    54:00 Whitening Options and Longevity

    01:00:25 Dental Cleaning Ingredients

    01:01:54 Fillings Materials and Safety

    01:06:53 Root Canals Mythbusting

    01:11:34 Veneers Hype and Downsides

    01:16:37 Gum Disease and Heart Health

    01:20:19 Ideal Oral Hygiene Plan

    01:24:10 Where to Find NOBS

    The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance.

    This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary.

    Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.

    Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary

    (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as

    Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).

    If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.

    Connect with Dr. Mike Hart

    Instagram: @drmikehart
    Twitter: @drmikehart
    Facebook: @drmikehart
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    1 時間 25 分
  • #236 The Cannabis Cure Controversy: Lee Whitley's Bold Claims

    #236 The Cannabis Cure Controversy: Lee Whitley's Bold Claims
    2026/09/03
    In this episode, Dr. Mike Hart sits down with Lee Whitley and physician Dr. Ira Price for a wide-ranging discussion about Lee's proprietary cannabis formulation and the extraordinary cancer-treatment claims surrounding it. Lee shares his own experience with stage IV squamous cell throat cancer, patient case stories, oral and injectable applications, dosing, and alleged pharmaceutical acquisition offers, while Dr. Price separates what he has personally observed from what has yet to be established through rigorous research. The conversation explores cannabinoids, THC, CBD, terpenes, chemotherapy and radiation, pathology and imaging, the limitations of anecdotal evidence, and the regulatory, funding, and data-access barriers standing between individual case reports and credible clinical trials. Lee Whitley is an entrepreneur and the creator of Lee's Oil and Lee Helps, a cannabis-based project that grew out of his personal experience with cancer and his years of developing and refining a proprietary cannabis formulation. He has since become an outspoken advocate for studying the results he says he has observed through formal clinical research. Dr. Ira Price is a physician with nearly two decades of experience prescribing cannabinoids and researching medical cannabis, including published work on cannabis for opioid substitution and years of lecturing internationally on cannabinoid medicine. Together, Whitley and Dr. Price bring two very different perspectives to the conversation—one shaped by personal experience and unconventional experimentation, and the other by clinical practice, scientific skepticism, and a focus on evidence, regulation, and properly designed trials. Lee Helps / Lee's Oil — Lee Whitley https://leehelps.com/ Cannabis for Opioid Substitution Trial (COST) — Dr. Ira Price / Cannabis Research Associates https://clinicaltrials.gov/study/NCT03859089 Cannabis Research Licensing — Health Canada https://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/industry-licensees-applicants/research-licensing-application.html Clinical Trials With Cannabis — Health Canada https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/announcements/notice-clarification-requirements-conducting-clinical-trials-cannabis.html Human Health Therapeutics Research Centre — National Research Council Canada https://www.nrc.canada.ca/en/research-development/research-collaboration/research-centres/human-health-therapeutics-research-centre Prescribing Drugs Policy — College of Physicians and Surgeons of Ontario (CPSO) https://www.cpso.on.ca/physicians/policies-guidance/policies/prescribing-drugs 4-Year-Old Cancer Case With 132 Tumors — Lee Whitley / Shit My Dad Taught Me https://www.iheart.com/podcast/1323-shit-my-dad-taught-me-264023145/episode/ep-22-lee-whitley-286273525/ Lee Helps Cancer & Melanoma Testimonials — Lee Whitley / Lee Helps Oil https://www.leehelpsoil.com/ Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:29 Claimed Cure Rates 01:59 Doctor Skepticism 03:47 Four Year Old Case 06:40 Colon Cancer Testimonial 09:43 Lee Cancer Story 14:28 Injection Timeline 16:00 Formula Breakdown 18:28 Terpenes Explained 21:29 Rick Simpson Comparison 24:52 How It Works 27:43 Chemo Radiation Debate 33:20 Injections Vs Pills 36:42 Research Roadblocks 44:03 Trial Plans Abroad 44:34 30 Women Trial Plan 46:02 Study Design Debate 47:23 Dosing Protocol Details 48:43 Big Pharma Buyout Claims 51:50 Suppression And Threats 55:12 What Happens After Success 57:59 Finding Patients And Reach 59:48 Treating More Than Cancer 01:06:51 How The Plant Was Found 01:13:47 Chemo Radiation Clash 01:17:59 Timeline And Publication 01:20:27 Closing Advice And Wrap The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut ...
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    1 時間 25 分
  • #235 Dr. Kenealy on Preventing Cancer: Lifestyle, Toxins, Hormones, Fasting, and Screening Beyond Tumors

    #235 Dr. Kenealy on Preventing Cancer: Lifestyle, Toxins, Hormones, Fasting, and Screening Beyond Tumors
    2026/08/27
    In this episode, Dr. Mike Hart sits down with Dr. Leigh Erin Connealy for a wide-ranging conversation on cancer prevention and the factors she believes influence long-term health. Dr. Connealy shares her perspective on why cancer should be approached as a whole-body problem, exploring the roles of nutrition, metabolic health, environmental toxins, sleep, stress, hormones, and mitochondrial function. They also discuss fasting and ketogenic diets, cancer screening, GLP-1 medications, aspirin, peptides, medicinal mushrooms, IV vitamin C, and other integrative approaches, along with Dr. Connealy's concerns about conventional screening and treatment practices. Throughout the conversation, she emphasizes individualized care and looking beyond a diagnosis to understand the broader conditions affecting each patient. Dr. Leigh Erin Connealy is a medical doctor with four decades of experience who takes a prevention-focused, whole-person approach to health, longevity, and complex chronic disease. Her work spans human optimization through advanced conditions including cancer, dementia, autoimmune disease, and Parkinson's, with an emphasis on identifying and addressing factors that may interfere with the body's ability to function optimally. Her approach was shaped in part by her own health journey after learning that she had been exposed before birth to DES (diethylstilbestrol), which led her to undergo ongoing evaluations at MD Anderson and explore medicine beyond conventional symptom-based care. Over her career, she has incorporated individualized laboratory assessment, natural hormones, nutrition, peptides, and other integrative strategies while emphasizing what she describes as "creating health" rather than simply treating a diagnosis. [The Cancer Revolution] — Leigh Erin Connealy, MD / Hachette Book Group https://www.hachettebookgroup.com/titles/leigh-erin-connealy/the-cancer-revolution/9780306836688/ [Be Perfectly Healthy] — Leigh Erin Connealy, MD / Perfectly Healthy https://perfectlyhealthy.com/products/be-perfectly-healthy-1 [Celluverse Podcast] — Dr. Leigh Erin Connealy, Alannah Connealy & Jess Donovan https://podcasts.apple.com/us/podcast/celluverse/id1836455844 [Dr. Leigh Erin Connealy Instagram — @connealymd] — Leigh Erin Connealy, MD https://www.instagram.com/connealymd/ [Cologuard Plus] — Exact Sciences Corporation https://www.cologuard.com/resources [QTI Breast Acoustic CT Scanner] — QT Imaging Holdings, Inc. https://www.qtimaging.com/breast-acoustic-ct-scanner/ [UT MD Anderson Cancer Center] — The University of Texas MD Anderson Cancer Center https://www.mdanderson.org/ [Eminence Organic Skin Care — Sun Care] — Eminence Organic Skin Care https://eminenceorganics.com/us/face/sun-care [Primally Pure Sunscreen] — Primally Pure https://primallypure.com/pages/sunscreen [COOLA Sunscreen] — COOLA https://coola.com/collections/sunscreen Show Notes 00:00 Welcome to the Hart2Heart Podcast 01:07 Root Cause Medicine 02:29 Is Cancer Preventable 05:42 Biggest Risk Factors 09:51 Toxins And Detox Testing 12:26 Sweating And Detox Baths 00:00 Doctors Not Listening 16:58 Does Sugar Feed Cancer 22:37 Fasting And Keto Strategies 26:05 Mushrooms And Supplements 27:21 Thiamine And Nutrient Gaps 29:35 Hormones And Cancer Risk 35:42 Complete Hormone Panels 38:02 GLP-1s and Cancer Risk 39:18 Daily Aspirin Debate 41:12 Peptides to Avoid 43:20 Russian Peptides Cycling 45:43 Non Toxic Sunscreen Choices 47:14 Deodorants and Aluminum 48:18 AirPods and Brain Health 50:26 Cancer Screening Strategy 54:30 Breast Imaging Options 56:05 Biopsy Spread Concerns 58:09 Why Medicine Misses Prevention 01:01:55 Personal DES Cancer Journey 01:03:10 IV Vitamin C for Cancer 01:04:26 Where to Follow and Book The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is ...
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    1 時間 6 分
  • #234 Navigating Weight Loss: Breaking Down Barriers with Dan Go

    #234 Navigating Weight Loss: Breaking Down Barriers with Dan Go
    2026/08/20
    After a five-year hiatus, Dan Go returns to break down a sustainable approach to fat loss for busy people who do not have hours to spend in the gym. He explains why identifying the main physiological or psychological bottleneck—such as late-night eating, stress, grazing, or weekend overeating—can matter more than simply handing someone a meal plan. The conversation covers calorie tracking for awareness, protein and fiber for satiety, meal timing, restaurant strategies, preserving muscle with low-volume strength training, FFMI as an alternative to BMI, and a balanced view of GLP-1 medications that considers both their benefits and trade-offs. Dan Go is a fitness coach and entrepreneur whose work focuses on helping busy professionals, founders, and entrepreneurs improve their body composition, health, and performance through sustainable nutrition, behavior change, and efficient training. His coaching approach emphasizes identifying the specific habits, beliefs, and environmental factors that make fat loss difficult, then building practical systems and guardrails that clients can maintain long term. Rather than relying on extreme diets or high-volume workouts, he focuses on awareness, consistency, adequate protein, structured eating, and time-efficient strength training to help clients lose fat while preserving muscle. [Dan Go Official Website] — Dan Go (Dan Go) https://www.dango.co/ [The High Performance Journal] — Dan Go (Dan Go) https://www.dango.co/newsletter [Dan Go on X] — Dan Go (X (formerly Twitter)) https://x.com/CoachDanGo [Dan Go on Instagram] — Dan Go (Instagram) https://www.instagram.com/coachdango/ [Dan Go Private Coaching] — High Performance Founder / Dan Go (High Performance Founder) https://highperformancefounder.com/private-coaching [Why I Quit Drinking Alcohol] — Mark Manson (Mark Manson) https://markmanson.net/why-i-quit-drinking-alcohol [A Satiety Index of Common Foods] — S. H. Holt, J. C. Miller, P. Petocz & E. Farmakalidis (PubMed) https://pubmed.ncbi.nlm.nih.gov/7498104/ [Fat-Free Mass Index (FFMI) Research] — Loenneke et al. (PubMed Central (PMC)) https://pmc.ncbi.nlm.nih.gov/articles/PMC3445648/ [ChatGPT] — OpenAI (ChatGPT) https://chatgpt.com/ [Claude] — Anthropic (Claude) https://claude.com/ [Mounjaro (tirzepatide)] — Eli Lilly and Company (Mounjaro) https://mounjaro.lilly.com/ [Ozempic (semaglutide)] — Novo Nordisk (Ozempic) https://www.ozempic.com/ Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:49 Rapid Fat Loss Setup 01:11 Find The Bottleneck 02:38 Late Night Eating Roots 04:21 Mark Manson Case Study 05:55 Metabolic Reset Phase 06:38 After Weight Loss Plan 09:29 Remove Obstacles First 10:59 Sustainable Diet Rules 13:03 No Cheat Meals 13:15 90 10 Ratio Diet 15:27 Tracking For Awareness 18:12 Calorie Blind Spots 19:45 Guardrails Not Counting 21:43 Satiety And Fiber 24:24 GLOP Protein Breakfast 28:36 Why Eat Breakfast 30:14 Breakfast Beats Stress 31:22 Night Eating Guardrails 32:53 Sleep and Late Meals 34:15 Restaurant Ordering Hacks 38:49 Keep Muscle While Cutting 45:30 FFMI Over BMI 47:31 GLP-1s Balanced Take 54:25 Dosing and Nutrition Guardrails 57:50 Men vs Women Fat Loss 59:58 Where to Find Dan Go The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
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    1 時間 1 分
  • #233 Understanding NAD+: Insights with Dr. Charles Brenner

    #233 Understanding NAD+: Insights with Dr. Charles Brenner
    2026/08/13
    Charles Brenner breaks down what the science actually says about NAD+, separating established findings from the claims commonly made in the longevity space. He explains why NAD levels in tissues may matter more than blood measurements, how metabolic stress, alcohol, inflammation, and other conditions can disrupt the NAD system, and how nicotinamide riboside (NR) compares with niacin, nicotinamide, and NMN. The conversation also covers research on exercise recovery, peripheral artery disease, skin health, infection, and wound healing, along with the limitations of current human evidence. Brenner explains why he advises against IV and subcutaneous NAD+, discusses concerns around NMN quality, and challenges popular sirtuin-centered theories of anti-aging while emphasizing the importance of reproducible human research. Charles Brenner is an NAD metabolism researcher whose work focuses on cellular bioenergetics, vitamin B3 biology, metabolic stress, and the pathways that regulate NAD production and utilization throughout the body. Now based at the University of Helsinki, his research has examined how the NAD system responds to conditions ranging from metabolic and liver disease to mitochondrial dysfunction, inflammation, and neurological stress. His work has also helped advance research into nicotinamide riboside as an NAD precursor and its potential applications in human health. Brenner takes an evidence-first approach to longevity science, distinguishing findings supported by controlled human studies from promising but still unproven mechanisms, animal research, and anecdotal claims. Brenner Lab — Charles Brenner, PhD https://www.brennerlab.net/ Niagen NR Clinical Studies — Niagen Bioscience https://www.niagenbioscience.com/pages/clinical-studies Nicotinamide Riboside for Peripheral Artery Disease — Mary M. McDermott et al. https://pubmed.ncbi.nlm.nih.gov/38871717/ This is the PAD study discussed in the episode where NR improved six-minute walking performance. NOPARK: Nicotinamide Riboside in Early Parkinson's Disease — Haukeland University Hospital / Norwegian Research Team https://clinicaltrials.gov/study/NCT03568968 This is the 400-participant, 52-week Parkinson's trial discussed in the transcript. Effects of Nicotinamide Riboside in Long COVID — Chao-Yi Wu, Edmarie Guzmán-Vélez, Charles Brenner et al. https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370%2825%2900567-X/fulltext This is the Long COVID study Brenner references when discussing cognition, fatigue, sleep, and symptom recovery. NAD+ Metabolome in Alcohol-Related Liver Disease — Richard Parker, Charles Brenner et al. https://pubmed.ncbi.nlm.nih.gov/32766477/ This is the human alcohol-related liver disease research Brenner discusses when explaining disturbed liver NAD metabolism. Nicotinamide for Skin-Cancer Chemoprevention — Andrew C. Chen et al. https://pubmed.ncbi.nlm.nih.gov/26488693/ This is the major Australian study relevant to Brenner's discussion of oral nicotinamide and skin cancer protection. Charles Brenner on NAD+, NR vs. NMN & NAD IVs — Dr. Rhonda Patrick / FoundMyFitness https://www.foundmyfitness.com/episodes/charles-brenner Dr. Mike specifically references Brenner's appearance with Rhonda Patrick during the episode. Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:58 NAD Basics Explained 02:22 Cellular Role of NAD 03:21 Proven Benefits and Trials 05:24 Inflammation Markers Deep Dive 09:19 Athletes Recovery and VO2 Max 13:52 Does NAD Decline With Age 20:10 Skin NAD and UV Damage 23:40 Who Should Take NR 27:56 Niacin vs NR vs NMN 32:28 NMN Conversion and Quality 35:37 IV and Injection Warnings 42:18 Dosing Timing and Alcohol 46:50 Addiction Claims and Dream Trials 51:39 Parkinsons and Long COVID Data 55:03 Sinclair Critique Revisited 57:05 Stacking Supplements and Metformin 59:58 Wrap Up and Where to Follow The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile ...
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    1 時間 1 分
  • #233 Understanding NAD+: Insights with Dr. Charles Brenner

    #233 Understanding NAD+: Insights with Dr. Charles Brenner
    2026/08/13
    Charles Brenner breaks down what the science actually says about NAD+, separating established findings from the claims commonly made in the longevity space. He explains why NAD levels in tissues may matter more than blood measurements, how metabolic stress, alcohol, inflammation, and other conditions can disrupt the NAD system, and how nicotinamide riboside (NR) compares with niacin, nicotinamide, and NMN. The conversation also covers research on exercise recovery, peripheral artery disease, skin health, infection, and wound healing, along with the limitations of current human evidence. Brenner explains why he advises against IV and subcutaneous NAD+, discusses concerns around NMN quality, and challenges popular sirtuin-centered theories of anti-aging while emphasizing the importance of reproducible human research. Charles Brenner is an NAD metabolism researcher whose work focuses on cellular bioenergetics, vitamin B3 biology, metabolic stress, and the pathways that regulate NAD production and utilization throughout the body. Now based at the University of Helsinki, his research has examined how the NAD system responds to conditions ranging from metabolic and liver disease to mitochondrial dysfunction, inflammation, and neurological stress. His work has also helped advance research into nicotinamide riboside as an NAD precursor and its potential applications in human health. Brenner takes an evidence-first approach to longevity science, distinguishing findings supported by controlled human studies from promising but still unproven mechanisms, animal research, and anecdotal claims. Brenner Lab — Charles Brenner, PhD https://www.brennerlab.net/ Niagen NR Clinical Studies — Niagen Bioscience https://www.niagenbioscience.com/pages/clinical-studies Nicotinamide Riboside for Peripheral Artery Disease — Mary M. McDermott et al. https://pubmed.ncbi.nlm.nih.gov/38871717/ This is the PAD study discussed in the episode where NR improved six-minute walking performance. NOPARK: Nicotinamide Riboside in Early Parkinson's Disease — Haukeland University Hospital / Norwegian Research Team https://clinicaltrials.gov/study/NCT03568968 This is the 400-participant, 52-week Parkinson's trial discussed in the transcript. Effects of Nicotinamide Riboside in Long COVID — Chao-Yi Wu, Edmarie Guzmán-Vélez, Charles Brenner et al. https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370%2825%2900567-X/fulltext This is the Long COVID study Brenner references when discussing cognition, fatigue, sleep, and symptom recovery. NAD+ Metabolome in Alcohol-Related Liver Disease — Richard Parker, Charles Brenner et al. https://pubmed.ncbi.nlm.nih.gov/32766477/ This is the human alcohol-related liver disease research Brenner discusses when explaining disturbed liver NAD metabolism. Nicotinamide for Skin-Cancer Chemoprevention — Andrew C. Chen et al. https://pubmed.ncbi.nlm.nih.gov/26488693/ This is the major Australian study relevant to Brenner's discussion of oral nicotinamide and skin cancer protection. Charles Brenner on NAD+, NR vs. NMN & NAD IVs — Dr. Rhonda Patrick / FoundMyFitness https://www.foundmyfitness.com/episodes/charles-brenner Dr. Mike specifically references Brenner's appearance with Rhonda Patrick during the episode. Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:58 NAD Basics Explained 02:22 Cellular Role of NAD 03:21 Proven Benefits and Trials 05:24 Inflammation Markers Deep Dive 09:19 Athletes Recovery and VO2 Max 13:52 Does NAD Decline With Age 20:10 Skin NAD and UV Damage 23:40 Who Should Take NR 27:56 Niacin vs NR vs NMN 32:28 NMN Conversion and Quality 35:37 IV and Injection Warnings 42:18 Dosing Timing and Alcohol 46:50 Addiction Claims and Dream Trials 51:39 Parkinsons and Long COVID Data 55:03 Sinclair Critique Revisited 57:05 Stacking Supplements and Metformin 59:58 Wrap Up and Where to Follow The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile ...
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    1 時間 1 分
  • #232 Testosterone Screening, Metabolic Health, and Hormone Optimization: Free T, SHBG, hCG, and Body Composition

    #232 Testosterone Screening, Metabolic Health, and Hormone Optimization: Free T, SHBG, hCG, and Body Composition
    2026/08/06
    This episode explores the opportunities and risks of testosterone optimization, beginning with the US military's decision to screen men over 30 for low testosterone. Dr. Mike Hart and Dr. Jonathan Schoeff discuss why symptoms such as fatigue, low libido, and difficulty changing body composition cannot be interpreted from a single lab value. They examine the importance of free testosterone, SHBG, insulin resistance, visceral fat, estradiol, DHT, fertility, and individualized dosing. The conversation also challenges common measures such as BMI and body fat percentage, emphasizing skeletal muscle mass, visceral adiposity, sustainable health goals, and the minimum effective intervention. Dr. Jonathan Schoeff is a spinal surgeon and longevity medicine practitioner whose work focuses on hormone health, metabolic optimization, body composition, and individualized health strategy. Through comprehensive laboratory testing, clinical assessment, and personalized treatment planning, he helps clients understand how hormones, insulin sensitivity, muscle mass, visceral fat, lifestyle, and long-term health goals interact. Describing his role as that of a "biological strategist," Dr. Schoeff emphasizes precision over standardized protocols and develops practical plans designed around each person's biology, priorities, and daily life. Health and Human Performance Optimization to Enhance Military Readiness — U.S. Department of War https://media.defense.gov/2026/Jul/15/2003961654/-1/-1/1/HEALTH%20AND%20HUMAN%20PERFORMANCE%20OPTIMIZATION%20TO%20ENHANCE%20MILITARY%20READINESS%20OSD004430-26%20RES%20FINAL.PDF Influence of CAG Repeat Polymorphism on the Targets of Testosterone Action — Giacomo Tirabassi et al. https://pubmed.ncbi.nlm.nih.gov/26421011/ Comparative Effects of Daily and Weekly Boron Supplementation on Plasma Steroid Hormones and Proinflammatory Cytokines — Mohammad Reza Naghii et al. https://pubmed.ncbi.nlm.nih.gov/21129941/ Women's Health Initiative — National Heart, Lung, and Blood Institute, National Institutes of Health https://www.nhlbi.nih.gov/science/womens-health-initiative-whi Surviving Sepsis Campaign Adult Guidelines — Society of Critical Care Medicine https://www.sccm.org/survivingsepsiscampaign/guidelines-and-resources/surviving-sepsis-campaign-adult-guidelines The Longevity Lab — Dr. Jonathan Schoeff and Candace Schoeff https://longevitylabwellness.com/ Jonathan Schoeff on Instagram — Dr. Jonathan Schoeff https://www.instagram.com/jonschoeff/ Jonathan Schoeff on YouTube — Dr. Jonathan Schoeff https://www.youtube.com/@drjonschoeff Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:42 Military Low T Screening 04:32 Normal Ranges and Treatment 08:19 Free Testosterone and Insulin 12:35 High SHBG and Enclomiphene 15:54 hCG Fertility and Protocols 19:35 Obesity Low T Strategy 23:26 Aromatase Inhibitors and Estrogen 26:51 DHT Mood and Libido Balance 28:57 DHT Balance Risks 30:10 Minimum Effective Dose 31:55 Longevity Strategy Mindset 33:31 Clinic Cuts Alcohol Use 35:40 Goals Drive Strategy 38:06 Body Fat Targets Debate 41:54 Sustainable Leanness 45:33 Personalized Nutrition Plans 48:09 Beyond Body Fat Metrics 52:29 Rules Not Regulations 53:31 Wrap Up And Where To Find The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
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    56 分