Episode 3 of DISCOVER SM – a podcast series developed for international HCPs to increase awareness of systemic mastocytosis (SM). This episode follows the next stage of the diagnostic journey: confirming a diagnosis of SM and explores how clinicians and pathologists piece together evidence from blood tests, bone marrow assessment, molecular testing, morphology, and immunophenotyping to build a complete diagnostic picture, while illustrating how the WHO diagnostic criteria are applied in clinical practice.

For more information on SM, visit our Discover SM website.

References: 1. Rets AV, George TI. Am J Clin Pathol. 2024;162(4):332–348. 2. Sotlar K, et al. J Allergy Clin Immunol Pract. 2022;10(8):1986–1998.e2. 3. Valent P, et al. J Allergy Clin Immunol Pract. 2022;10(8):1999–2012.e6. 4. Sánchez-Muñoz L, et al. Mod Pathol. 2011;24(9):1157–116 5. Zanotti R, et al. Mediterr J Hematol Infect Dis. 2021;13(1):e2021068. 6. Valent P, et al. Hemasphere. 2021;5(11):e646. 7. WHO Classification of Tumours Editorial Board. Haematolymphoid tumours [Internet]. Lyon (France): International Agency for Research on Cancer. Available at: https://tumourclassification.iarc.who.int/chapters/63. Accessed July 2026. 8. Ungerstedt J, et al. Cancers (Basel). 2022;14(16):3942. 9. Tse KY, et al. J Allergy Clin Immunol Glob. 2024;3(4):100316.

INTBP-DAXSM-26.030

Episode 2 of DISCOVER SM – a podcast series developed for international HCPs to increase awareness of systemic mastocytosis (SM). This episode provides a practical overview of SM, discussing its common signs and symptoms, typical diagnostic pathways, and key diagnostic tests. Expert clinicians share their insights on recognising key findings and guiding the diagnostic process.

For more information on SM, visit our Discover SM website.

References: 1. Ungerstedt J, et al. Cancers (Basel). 2022;14(16):3942. 2. Schwaab J, et al. J Allergy Clin Immunol Pract. 2020;8(9):3121–3127.e1. 3. Valent P, et al. J Allergy Clin Immunol Pract. 2022;10(8):1999–2012.e6

INTBP-DAXSM-25.022

Episode 1 of DISCOVER SM – a podcast series developed for international HCPs to increase awareness of systemic mastocytosis (SM). This episode provides an introduction to SM, exploring its origins, key features, and subtypes. Expert insights highlight how the understanding of SM has evolved over time, setting the foundation for recognising and diagnosing this rare disease.

For more information on SM, visit our Discover SM website.

References: 1. Gülen T, et al. J Intern Med. 2016;279(3):211–228. 2. Ungerstedt J, et al. Cancers (Basel). 2022;14(16):3942. 3. Valent P, et al. Cancer Res. 2017;77(6):1261–1270. 4. Rare Disease Advisor. Systemic Mastocytosis History. Available at: https://www.rarediseaseadvisor.com/hcp-resource/systemic-mastocytosis-history/. Last accessed October 2025. 5. Jensen RT. Hematol Oncol Clin North Am. 2000;14(3):579-623. 6. Theoharides TC, et al. N Engl J Med. 2015;373(2):163–172. 7. Gilreath JA, et al. Clin Pharmacol. 2019;11:77–92. 8. Pyatilova P, et al. World Allergy Organ J. 2023;16(11):100838. 9. Universitätsklinik für Innere Medizin I. Reference Centers. Available at:https://innere-med-1.meduniwien.ac.at/unsere-klinischen-abteilungen/haematologie-und-haemostaseologie/projekte/ecnm-registry-european-competence-network-mastocytosis/centers/reference-centers/. Last accessed October 2025. 10. Valent P, et al. J Allergy Clin Immunol Pract. 2022;10(8):1999–2012.e6. 11. Berezowska S, et al. Mod Pathol. 2014;27(1):19–29. 12. Valent P, et al. Hemasphere. 2021;5(11):e646. 13. Arber DA, et al. Blood. 2022;140(11):1200–1228. 14. Khoury JD, et al. Leukemia. 2022;36(7):1703–1719. 15. Pardanani A. Am J Hematol. 2023;98(7):1097–1116. 16. Veitch S, Radia DH. Diagnostics (Basel). 2023;14(1):80. 17. Levedahl KH, et al. Eur J Oncol Nurs. 2022:60:102172. 18. Triggiani M, et al. Clin Exp Allergy. 2025;55(9):784–794. 19. Jennings SV, et al. Immunol Allergy Clin North Am. 2018;38(3):505–525.

INTBP-DAXSM-25.021, 10/2025