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Beginning in the 1970s, several scientific breakthroughs promised to transform the creation of new medicines. As investors sought to capitalize on these Nobel Prize-winning discoveries, the biotech industry grew to thousands of small companies around the world. Each sought to emulate what the major pharmaceutical companies had been doing for a century or more, but without the advantages of scale, scope, experience, and massive resources. From Breakthrough to Blockbuster focuses on both the companies themselves and the broader biotech ecosystem that supports them. 

Teenagers are tired, strapped for time, and often asked to wake up far earlier than they should due to school start times. In The Sleep-Deprived Teen, Lisa L. Lewis, who helped spark the first law in the nation requiring healthy school start times for adolescents, has written a book for parents who want to help their fatigued teens sleep well. Poor sleep affects mental health, athletic performance, and academic success. It contributes to adolescent depression, anxiety, and even drowsy driving. When teens are well-rested, they're happier, healthier, and more resilient.

Over a stellar career, Roger Martin has advised the CEOs of some of the world's most successful companies. From the beginning, he noted that almost every executive he talked to had a "model"—a framework or way of thinking that guided their strategy and activities. But these models tended to become automatic, so much so that when one didn't work, the typical response was just to apply it again—with greater enthusiasm.

The moment Blair Jensen sneered jock at me, I was captivated. Then she poured a beer over my head and walked away like I was nothing. Nobody turned down Cage Wilder, nobody, and I knew then that I had to have her, no matter the consequences. She bruised my ego and embarrassed me in front of my football buddies, turning me into the laughing stock of the team, so I made a bet with them. They claimed there wasn’t any way I could melt the heart of Blair the Ice Queen; after all, she had shown her disgust for me.

This is the dramatic and inspirational first-person story of theoretical physicist Dr. Ronald Mallett, who recently discovered the basic equations for a working time machine that he believes can be used as a transport vehicle to the past. Combining elements of Rocket Boys and Elegant Universe, Time Traveler follows Mallett's discovery of Einstein's work on space-time, his study of Godel's work on a solution of Einstein's equation that might allow for time travel.

This book is intended for the clinical researcher who is interested in designing a clinical trial and developing a protocol. It is also of value to researchers and practitioners who must critically evaluate the literature of published clinical trials and assess the merits of each trial and the implications for the care and treatment of patients. The authors use numerous examples of published clinical trials to illustrate the fundamentals.

I truly love this book, The Marvelous Land of Oz, by Lyman Frank Baum. It brings up so many memories of childhood when I read it for the first time. Through my life, I have heard this book referenced many times due to its popularity and significance. I hope this book continues to impact the lives of others the way it has impacted mine.

Anne of the Island was published in 1915 covering her from the ages of 18 to 22. This is the third story of Anne Shirley where she earns her BA at Redmond College. In this book, she enjoys new and old friends at Redmond, living together at Patty's Place chaperoned by Aunt Jamesina. Gilbert proposes to Anne and she rejects him - but you must listen to the story to know the rest!

Saying "don’t" around Jack Harrison always did lead him into dangerous grounds on London streets. But now someone knows Jack’s head inside and out, and they’re about to twist all perception and lead him into an underground depravity that nearly sent him down in his youth. As Jack slips further into a dark psychological minefield, only two men offer different paths back to sanity...it’s a fight to see who out of the three of them will survive long enough to find a way out of the vicious game played by someone known only as...the Unknown.

A disabled teen, an empathetic dragon, and a bond that will save the world. Sixteen-year-old Amel arrived at Dragon School just like everyone else - with a dream to ride dragons and join the Dominion Dragon Riders. But Amel has a crippled leg, and Dragon School training is grueling. Before she can even become an initiate, she must complete her first flight on a dragon. Can Amel survive First Flight and become a Dragon School initiate, or will her dreams dash on the rocks below?

They say your first kiss should be earned. Mine was stolen by a devil in a masquerade mask under the black Chicago sky. They say the vows you take on your wedding day are sacred. Mine were broken before we left church. They say your heart only beats for one man. Mine split and bled for two rivals who fought for it until the bitter end. I was promised to Angelo Bandini, the heir to one of the most powerful families in the Chicago Outfit. Then taken by Senator Wolfe Keaton, who held my father’s sins over his head to force me into marriage.

Castle Joiry had been taken. The heavy boots of invaders rang in the hallways, and the arching ceiling echoed back the clash of falling swords. Still struggling violently, Joiry's commander was brought before the conqueror. Standing tall, armor running red with blood, Jirel of Joiry refused to surrender her home and vowed to her enemy that his victory would cost him his life, and more. That very night, Joiry's lady crept by secret ways to the castle's deepest dungeon.

Trasportata da un tornado in un luogo favoloso, Dorothy si avvia con i suoi nuovi amici - lo spaventapasseri, il Boscaiolo di Latta e il Leone Codardo - lungo la strada di mattoni gialli verso la scintillante Città di Smeraldo. Qui risiede il Mago di Oz, l'unico che potrà aiutarla a tornare a casa.

Michael Jackson's reign as the King of Pop is celebrated in the latest biographical audiobook from Bluewater Productions. The newest addition to the publisher's critically acclaimed library features a foreword by artist and friend of Jackson's Giuseppe Mazzola. The life of the world's most popular entertainer was infused with fantasy and tragedy. His discography is legendary. His legacy is complicated and unparalleled.

My name is Melody Greene, and I have a confession to make. I slept with my student, a senior in high school. Multiple times. I had multiple orgasms. In multiple positions. I slept with my student and I enjoyed it. I slept with my student and I'd do it all over again if I could turn back time. My name is Melody Greene, and I got kicked out of my position as a teacher and did my walk of shame a la Cersei Lannister from the principal's office, minutes after said principal threatened to call the cops on me.

#1 NEW YORK TIMES BESTSELLER “A great American success story . . . an endearing and well-written book.”—The New York Times Book Review Colin Powell is the embodiment of the American dream. He was born in Harlem to immigrant parents from Jamaica. He knew the rough life of the streets...

Under the Sea Wind is a classic wilderness adventure to which all nature writing is compared. The hero of Under the Sea Wind is soon seen to be life itself, that quicksilver prize granted, for a brief time only, to the clever and the fortunate.

In the fifth book in the series, Anne's own true love, Gilbert Blythe, is finally a doctor, and, in the sunshine of the old orchard among their dearest friends, they are about to speak their vows. Soon, the happy couple will be bound for a new life together in their own dream house on the misty purple shores of Four Winds Harbor. But a new life means fresh problems to solve - and fresh surprises. As Anne and Gilbert begin to build that new life, some of those problems and surprises come in the form of their new neighbors.

With a string of number-one hits showcasing Karen Carpenter's warm and distinctive vocals and Richard Carpenter's sophisticated compositions and arrangements, the Carpenters were responsible for some of the most popular music of the 1970s, and this compendium collects more than 50 articles, interviews, essays, reviews, and reassessments that chronicle the lives and career of this brother-sister musical team.

E L James revisits the world of Fifty Shades with a deeper and darker take on the love story that has enthralled millions of readers around the globe. Look for E L James’ passionate new love story, The Mister, available now. Christian Grey exercises control in all things; his world is neat...