検索キーワード： 進化・遺伝学

To better understand the inner workings of our bodies and to trace the origins of many of today's most common diseases, we have to turn to unexpected sources: worms, flies, and even fish.

Tucked away in Siberia, there are furry, four-legged creatures with wagging tails and floppy ears that are as docile and friendly as any lapdog. But, despite appearances, these are not dogs - they are foxes. They are the result of the most astonishing experiment in breeding ever undertaken - imagine speeding up thousands of years of evolution into a few decades. In 1959, biologists Dmitri Belyaev and Lyudmila Trut set out to do just that, by starting with a few dozen silver foxes from fox farms in the USSR and attempting to recreate the evolution of wolves into dogs in real time.

Around 250,000 people have had their genomes sequenced, and scientists expect that number to rise to one billion by 2025. Professor Steven J. Heine argues that the first thing we will do on receiving our DNA test results is to misinterpret them completely. Despite breathless (often lightly researched) media coverage about newly discovered "cancer" or "divorce" or "IQ" genes, the prospect of a DNA test forecasting how your life is going to turn out is vanishingly small.

By identifying the structure of DNA, the molecule of life, Francis Crick and James Watson revolutionized biochemistry and won themselves a Nobel Prize. At the time, Watson was only 24, a young scientist hungry to make his mark. His uncompromisingly honest account of the heady days of their thrilling sprint against other world-class researchers to solve one of science's greatest mysteries gives a dazzlingly clear picture of a world of brilliant scientists with great gifts, very human ambitions, and bitter rivalries.

In the mid-1970s, scientists began using DNA sequences to reexamine the history of all life. Perhaps the most startling discovery to come out of this new field is horizontal gene transfer (HGT), or the movement of genes across species lines. For instance, we now know that roughly eight percent of the human genome arrived not through traditional inheritance from directly ancestral forms, but sideways by viral infection - a type of HGT. In The Tangled Tree David Quammen chronicles these discoveries through the lives of the researchers who made them.

It is widely understood that Charles Darwin’s theory of evolution completely revolutionized the study of biology. Yet, according to David Sloan Wilson, the Darwinian revolution won’t be truly complete until it is applied more broadly - to everything associated with the words “human,” “culture,” and “policy.”

Stepping effortlessly from myth to cutting-edge science, Mutants gives a brilliant narrative account of our genetic code and the captivating people whose bodies have revealed it - a French convent girl who found herself changing sex at puberty; children who, echoing Homer's Cyclops, are born with a single eye in the middle of their foreheads; a village of long-lived Croatian dwarves; one family, whose bodies were entirely covered with hair, was kept at the Burmese royal court for four generations and gave Darwin one of his keenest insights into heredity.

In Survival of the Prettiest, Nancy Etcoff, a faculty member at Harvard Medical School and a practicing psychologist at Massachusetts General Hospital, argues that beauty is neither a cultural construction, an invention of the fashion industry, nor a backlash against feminism - it's in our biology.

From leading geopolitical expert and technology futurist Jamie Metzl comes a groundbreaking exploration of the many ways genetic engineering is shaking the core foundations of our lives-sex, war, love, and death. At the dawn of the genetics revolution, our DNA is becoming as readable, writable, and hackable as our information technology. But as humanity starts retooling our own genetic code, the choices we make today will be the difference between realizing breathtaking advances in human well-being and descending into a dangerous and potentially deadly genetic arms race.

First coined by Richard Dawkins in The Selfish Gene, a meme is any idea, behavior, or skill that can be transferred from one person to another by imitation. Susan Blackmore shows that once our distant ancestors acquired the crucial ability to imitate, a second kind of natural selection began, a survival of the fittest amongst competing ideas and behaviors. Ideas and behaviors that proved most adaptive-making tools, for example, or using language - survived and flourished, replicating themselves in as many minds as possible.

Locked inside the DNA of every species that ever lived are endless stories - about origins, ancestors, fate, and much more. Until recently, these secrets were completely inaccessible. But with the help of new technologies, scientists are now reading the hidden history of DNA, making remarkable discoveries about ourselves and our fellow species. Your gateway to this treasure trove of information is Unlocking the Hidden History of DNA, 12 informative and accessible lectures delivered by New York Times best-selling author Sam Kean.

The Big Ratchet is the story of the ratchets: the technologies and innovations, big and small, that propelled our species from hunters and gatherers on the savannahs of Africa to shoppers in the aisles of the supermarket. Our species long lived on the edge of starvation. Now we produce enough food for all 7 billion of us to eat nearly 3,000 calories every day. This is such an astonishing thing in the history of life as to verge on the miraculous. The Big Ratchet is the story of how it happened.

The sixth "mass extinction event" in the history of planet Earth is currently under way, with over two hundred species dying off every day. The cause of this seismic event is also the source of the single biggest threat to human life: our own inventions. But for all our talk about sea levels and biotechnology, do we really know what our future will actually look like? Will our immune systems be attacked by so-called super bugs, always evolving, and more easily spread than ever? Will the disappearance of numerous species cripple the biosphere?

In Cracking the Aging Code, theoretical biologist Josh Mitteldorf and award-winning writer and ecological philosopher Dorion Sagan reveal that evolution and aging are even more complex and breathtaking than we originally thought. Using meticulous multidisciplinary science as well as reviewing the history of our understanding about evolution, this book makes the case that aging is not something that "just happens", nor is it the result of wear and tear or a genetic inevitability.

High in the Canadian Rockies is a small limestone quarry formed 530 million years ago called the Burgess Shale. It holds the remains of an ancient sea where dozens of strange creatures lived—a forgotten corner of evolution preserved in awesome detail. In this book, Stephen Jay Gould explores what the Burgess Shale tells us about evolution and the nature of history.

Cuteness is an area where culture and biology get tangled up. Seeing a cute animal triggers some of the most powerful psychological instincts we have – the ones that elicit our care and protection – but there is a deeper story behind the broad appeal of Japanese cats and saccharine greetings cards. Joshua Paul Dale, a pioneer in the burgeoning field of cuteness studies, explains how the cute aesthetic spread around the globe, from pop brands to Lolita fashion, kids' cartoons and the unstoppable rise of Hello Kitty.

Control is a book about what geneticist Adam Rutherford calls “a defining idea of the twentieth century.” Inspired by Darwin’s ideas about evolution, eugenics arose in Victorian England as a theory for improving the British population, and quickly spread to America. With disarming wit and scientific precision, Rutherford explains why eugenics still figures prominently in the twenty-first century, despite its genocidal past. And he confronts insidious recurring questions, revealing the intellectual bankruptcy of the idea, and the scientific impossibility of its realization.

As the planet emerged from the last ice age, a language was born between Europe and Asia, by the Black Sea. This ancient tongue, which we call Proto-Indo-European, soon exploded out of its cradle, changing and fragmenting as it went, until its offspring were spoken from Scotland to China. Today those descendants constitute the world’s largest language family, the thread that connects disparate cultures: Dante’s Inferno to the Rig Veda, The Lord of the Rings to the love poetry of Rumi. Indo-European languages are spoken by nearly half of humanity. How did this happen?

The Ape That Understood the Universe is the story of the strangest animal in the world: the human animal. It opens with a question: How would an alien scientist view our species? What would it make of our sex differences, our sexual behavior, our child-rearing patterns, our moral codes, our religions, our languages, and science? The book tackles these issues by drawing on ideas from two major schools of thought: evolutionary psychology and cultural evolutionary theory.

Epigenetics is the science of living DNA, charting the chemical pathways that spur DNA into action by turning genes on and off. While the Human Genome Project of the early 2000s was hailed as the key to understanding human heredity and disease, that historic effort was just the beginning. It has taken epigenetics to fill in the picture, explaining how the fixed code of our genome is implemented in countless living processes.

The discovery of DNA’s structure is the story of five towering minds in pursuit of the advancement of science, and for almost all of them, the prospect of fame and immortality: Watson, Crick, Rosalind Franklin, Maurice Wilkins, and Linus Pauling. Howard Markel skillfully recreates the intense intellectual journey, and fraught personal relationships, that ultimately led to a spectacular breakthrough. But it is Rosalind Franklin - fiercely determined, relentless, and an outsider at Cambridge and the University of London in the 1950s - who becomes a focal point for Markel.

In the beginning, Earth was an inhospitably alien place—in constant chemical flux, covered with churning seas, crafting its landscape through incessant volcanic eruptions. Amid all this tumult and disaster, life began. The earliest living things were no more than membranes stretched across microscopic gaps in rocks, where boiling hot jets of mineral-rich water gushed out from cracks in the ocean floor. In A (Very) Short History of Life on Earth, Henry Gee zips through the last 4.6 billion years with infectious enthusiasm and intellectual rigor.

“There is no good reason why human societies should not be described and explained with the same precision and success as the rest of nature.” Thus argues evolutionary psychologist Pascal Boyer in this uniquely innovative book. Integrating recent insights from evolutionary biology, genetics, psychology, economics, and other fields, Boyer offers precise models of why humans engage in social behaviors such as forming families, tribes, and nations, or creating gender roles.

Could extinct species, like mammoths and passenger pigeons, be brought back to life? The science says yes. In How to Clone a Mammoth, Beth Shapiro, evolutionary biologist and pioneer in "ancient DNA" research, walks listeners through the astonishing and controversial process of de-extinction.

The number-one Sunday Times best seller. A fascinating explanation of how evolution works from best-selling author of The God Delusion, Richard Dawkins. Complete and unabridged and read by Richard Dawkins and Lalla Ward. The river of Dawkins' title is a river of DNA, flowing through time from the beginning of life on Earth to the present and onwards.

In the great halls of science, dogma holds that Darwin's theory of natural selection explains every branch on the tree of life: which species thrive, which wither away to extinction, and what features each evolves. But can adaptation by natural selection really account for everything we see in nature? Yale University ornithologist Richard Prum - reviving Darwin's own views - thinks not.

Until very recently, if you were to ask most doctors, they would tell you there were only two kinds of medicine: the quack kind, and the evidence-based kind. The former is baseless, and the latter based on the best information human effort could buy. Well, Eric Topol isn't most doctors, and he suggests you entertain the notion of a third kind of medicine, one that will make the evidence-based state-of-the-art stuff look scarcely better than an alchemist trying to animate a homunculus in a jar.

Dr. Carl Sagan takes us on a great adventure, offering his vivid and startling insight into the brain of man and beast, the origin of human intelligence, the function of our most haunting legends - and their amazing links to recent discoveries.

For over a century, opening the black box of embryonic development was the holy grail of biology. Evo Devo--Evolutionary Developmental Biology--is the new science that has finally cracked open the box. Within the pages of his rich and riveting book, Sean B. Carroll explains how we are discovering that complex life is ironically much simpler than anyone ever expected.

In this eye-opening work, Graziano accessibly explores how this sense of an inner being led to empathy and formed us into social beings. The theory may point the way to engineers for building consciousness artificially. Graziano discusses what a future with artificial consciousness might be like, including both advantages and risks, and what AI might mean for our evolutionary future.