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Given how bad some of Rome's emperors were, it's a testament to just how insane and reviled Caligula was that he is still remembered nearly 2,000 years later as the epitome of everything that could be wrong with a tyrant. The Romans had high hopes for him after he succeeded Tiberius in 37 AD, and by all accounts he was a noble and just ruler during his first few months in power. But after that, he suffered some sort of mysterious illness that apparently rendered him insane.

The success of the emperors ironically brought about the worst plague in Rome’s epic history. Due to constant warfare on the borders and attempts to defend positions against various groups, Roman soldiers came into contact with foreign diseases, and they unwittingly brought them home when campaigns ended. This culminated around 165 CE, when an unidentified disease brought the empire to its knees and afflicted an untold number of individuals, one of whom may have been Lucius Verus, the co-emperor of Rome alongside Marcus Aurelius.