Clinical Misfits returns for Season Two with a deeper, more conversational approach to the connections between neurodivergence and complex chronic illness.

In this episode, Dr Mary revisits ideas explored in Season One before turning her attention to hypermobile Ehlers-Danlos syndrome (hEDS), dysautonomia and their relationship with neurodivergence. She explores the potential role of chondroitin sulfate in connective tissue and the nervous system, including its involvement in structures surrounding nerve cells known as perineuronal nets.

From there, Dr Mary considers how differences in synaptic pruning could influence the way neurodivergent nervous systems process and retain signals. Using pain and the body's autonomic response as an example, she explores a possible connection between neurological development, heightened nervous-system responses and the complex physical symptoms experienced by many neurodivergent people.

Produced for the Autistic Culture Podcast Network.

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