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  • The Hematopoietic Stem Cell Niche and Implications for Clinical Transplantation

    The Hematopoietic Stem Cell Niche and Implications for Clinical Transplantation
    2025/09/15
    Sean Morrison, Ph.D., from the Children’s Medical Center Research Institute at UT Southwestern, investigates how stem cells function, regenerate, and interact with their surrounding environment in the bone marrow. His research reveals how leptin receptor-positive cells—key components of the bone marrow niche—regulate hematopoietic stem cell maintenance and regeneration, influence platelet production, and respond to physiological stress like pregnancy. Morrison uncovers a reciprocal relationship between these niche cells and peripheral nerves, showing that disrupting nerve signals impairs bone marrow recovery after chemotherapy or radiation. His work also links retrotransposon activation during pregnancy to increased red blood cell production, with implications for maternal health and transplant medicine. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40449]
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    54 分
  • Cellular Reprogramming in Human Disease

    Cellular Reprogramming in Human Disease
    2025/09/13
    Deepak Srivastava, MD, explores how cellular reprogramming offers new hope for treating heart disease. He highlights innovative strategies to regenerate damaged heart tissue by stimulating adult cardiomyocytes to divide and converting fibroblasts into heart-like cells. His team develops a nonviral delivery system using lipid nanoparticles and investigates the role of specific gene regulators in restoring heart function in animal models. Srivastava also discusses a potential oral therapy for aortic valve disease, driven by insights into cellular fate changes caused by NOTCH1 mutations and telomere shortening. Additionally, he reveals how trisomy 21 may trigger congenital heart defects by altering the identity of specialized heart cells. Through pioneering research in genetics and regenerative medicine, Srivastava demonstrates how understanding developmental biology can lead to transformative clinical advances. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40447]
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    58 分
  • Panic!: The Sound of Fury

    Panic!: The Sound of Fury
    2025/09/13
    Film historian Rebecca Prime joins moderator Ross Melnick (Film and Media Studies, UCSB) for a discussion of the classic Hollywood film The Sound of Fury. Prime outlines the film’s production history and how its political and social commentary was shaped by its director, Cy Endfield, who would go on to be blacklisted due to his association with the Communist Party. They further discuss Endfield’s subsequent work in London and how he struggled with the blacklist for the rest of his career. Series: "Carsey-Wolf Center" [Humanities] [Show ID: 40919]
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    34 分
  • Why Research Funding Matters: A Patient Perspective

    Why Research Funding Matters: A Patient Perspective
    2025/09/11
    Kimberly Peters, a stage four uterine cancer patient at UC San Diego Health, urges government leaders not to cut science funding. She warns that reduced federal support risks delaying vital research and life-saving cures. [Health and Medicine] [Show ID: 41071]
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    1 分
  • Earth Works: The Cultural Evolution of Farm Workers

    Earth Works: The Cultural Evolution of Farm Workers
    2025/09/09
    Explore the evolving identities, histories, and rights of farmworkers across Mexico and the United States. Panelists—including scholars, organizers, and agricultural leaders—discuss cross-border migration, labor conditions, cultural heritage, and the impact of policies on communities. The conversation highlights the role of indigenous and Catholic traditions, the legacy of the Bracero Program, and the continuing struggles and resilience of agricultural workers. It also examines how economic and environmental pressures shape migration, labor organizing, and efforts to create sustainable, dignified livelihoods for future generations. Series: "Future Thought Leaders" [Public Affairs] [Agriculture] [Business] [Show ID: 40584]
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    1 時間 38 分
  • Bach Lives!

    Bach Lives!
    2025/09/09
    Considered the godfather of A.I. music, UC Santa Cruz professor and composer David Cope, who died in May, 2025, developed the computer program EMI, or Experiments in Musical Intelligence, in the 1980s. It was one of the earliest computer algorithms used to generate classical music. This documentary film by UC Santa Cruz's Bob Giges looks at the impact of Cope's genius on the world of music. Series: "Arts Channel " [Science] [Arts and Music] [Show ID: 40968]
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    25 分
  • One Doctor's Journey Through the AIDS Epidemic

    One Doctor's Journey Through the AIDS Epidemic
    2025/09/08
    On his very first day at San Francisco General Hospital, Dr. Paul Volberding met his first AIDS patient – a moment that shaped his career and left an indelible mark on the fight against an epidemic. Now, more than 40 years later, Volberding reflects on the creation of Ward 86, the nation’s first HIV clinics, and how UCSF’s compassionate, community-first approach redefined HIV/AIDS care worldwide. The work of Volberding and UCSF’s dedicated clinicians and scientists laid the foundation for advancements that continue to save lives today. [Health and Medicine] [Show ID: 40986]
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    7 分
  • Neuromodulation Pharmacogenetics and Imaging: Biological Approaches to Tailoring Therapy

    Neuromodulation Pharmacogenetics and Imaging: Biological Approaches to Tailoring Therapy
    2025/09/07
    As part of the 2025 Developmental Disabilities Conference, Dr. Elysa Marco talks about various biological approaches to therapy. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 40623]
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    42 分