TWiN unpacks a striking paradox, that the very cell divisions that built the human brain's most advanced layers also put them at greatest risk, and how a dedicated DNA repair pathway saves them.

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• MicrobeTV Discord Server
• Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair (Nature)
• Timestamps by Jolene Ramsey. Thanks!

Music is by Ronald Jenkees

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TWiN explains the finding that vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits in mice via synthesis of a sphingosine derivative on neonatal skin.

.Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

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• MicrobeTV Discord Server
• Vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits (Cell Host Microbe)
• Timestamps by Jolene Ramsey. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

TWiN explains the finding that activation of intracellular, not plasma membrane, serotonin 2A receptors is responsible for the plasticity-promoting and antidepressant-like properties of psychedelic compounds.

Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

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• MicrobeTV Discord Server
• Psychedelics rewire the brain from within (Science)
• Psychedelics elicit their effects by Gi signaling (Nature)
• History of LSD (Wikipedia)
• Timestamps by Jolene Ramsey. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv