TWiN unpacks a striking paradox, that the very cell divisions that built the human brain's most advanced layers also put them at greatest risk, and how a dedicated DNA repair pathway saves them.

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• Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair (Nature)
• Timestamps by Jolene Ramsey. Thanks!

Music is by Ronald Jenkees

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TWiN explains the finding that vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits in mice via synthesis of a sphingosine derivative on neonatal skin.

.Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

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• Vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits (Cell Host Microbe)
• Timestamps by Jolene Ramsey. Thanks!

Music is by Ronald Jenkees

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TWiN explains the finding that activation of intracellular, not plasma membrane, serotonin 2A receptors is responsible for the plasticity-promoting and antidepressant-like properties of psychedelic compounds.

Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

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• Psychedelics rewire the brain from within (Science)
• Psychedelics elicit their effects by Gi signaling (Nature)
• History of LSD (Wikipedia)
• Timestamps by Jolene Ramsey. Thanks!

Music is by Ronald Jenkees

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TWiN explains the role of a ubiquitin ligase component in regulating the sheathing of multiple axons by Schwann cells.

Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

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• Gut microbiome promotes pain in fibromyalgia (Neuron)
• Timestamps by Jolene Ramsey. Thanks!

Music is by Ronald Jenkees

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TWiN explains a study which showed that transplanting gut microbiota from women with fibromyalgia into mice induces pain, as well as phenotypes commonly observed in patients, such as immune activation, metabolomic changes, and reduced skin innervation.

Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

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• Gut microbiome promotes pain in fibromyalgia (Neuron)
• Timestamps by Jolene Ramsey. Thanks!

Music is by Ronald Jenkees

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TWiN explores the use of speech brain-computer interfaces to restore communication to people with paralysis, and reveals strategies for protecting private inner speech.

Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

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• MicrobeTV Discord Server
• Keeping private inner speech from brain-computer interfaces (Cell)
• Mind-reading brain implant with password protection (Nature)
• Timestamps by Jolene Ramsey. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv