TWiM explains the connection between inflammation caused by microbial glycogen in the gut and amyotrophic lateral sclerosis, and how disruption of cysteine metabolism leads to synthetic lethality and in vivo fitness impairment in Acinetobacter baumannii.

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Links for this episode:

• Myeloid cell gene prevents inflammatory response to microbial glycogen (Cell Rep)

• Cysteine metabolism and fitness impairment in Acinetobacter baumannii (mBio)
  
  

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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TWiM visits Tufts University School of Medcine and are joined by John Coffin, Michael Malamy, and Verna Manni for a tribute to Elio Schaechter who was chair of Molecular Biology and Microbiology for 23 years.

Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Petra Levin

Guests: John Coffin, Michael Malamy, and Verna Manni

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Music used on TWiM is by Ronald Jenkees.

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TWiM explains how Streptococcus mitis bacteriocins drive contact-dependent lysis of S. pneumoniae facilitating transformation, and microbial dominance in diabetic foot osteomyelitis determined with nanopore sequencing.

Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson

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• Streptococcus mitis bacteriocins drive contact-dependent lysis of S. pneumoniae (mBio)
• Microbial dominance in diabetic foot osteomyelitis determined with nanopore sequencing (J Inf Dis)
• Diabetic foot ulcer review (World J Clin Cases)
• How nanopore sequencing works (YouTube)

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Music used on TWiM is by Ronald Jenkees.

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TWiM explains how an enhanced domestication method allows for growth of uncultured bacteria, and identification of the oncogene SLC35F2 as is a high-specificity transporter for the micronutrients queuine and queuosine.

Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson.

Guest: Mark O. Martin

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

• Domestication method for uncultured bacteria (ISME Comm)
• Transporter for the micronutrients queuine and queuosine (PNAS)
• How diet and microbiome can impact your health (UF blog)
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TWiM explains a candidate signature of health in the gut microbial community, and how an intestinal bacterium exacerbates cardiac ischemia/reperfusion injury.

Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson and Petra Levin.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

• A candidate signature of health in the gut microbiome (Cell Host Microbe)
• 204,938 reference genomes from the human gut microbiome (Nat Biotech)
• A human gut metagenome-assembled genome catalogue spanning 41 countries (Nat Micro)
• A comprehensive ruminant microbial catalog (Gigascience)
• Bacteroides acidifaciens exacerbates cardiac ischemia/reperfusion injury (Cell Host Microbe)
• The Great Ozempic Experiment (NY Times, paywall)
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TWiM explains how to use microbes to enhance maize yield and reduce corn rootworm damage, and how the human microbiota modulates IgE-mediated reactions to foods through allergen metabolism.

Hosts: Michael Schmidt, Petra Levin, and Michele Swanson.

Guest: Mark O. Martin

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

• Harnessing Microbes for Crop Production (Phytobiome J)
• Microbes take on corn rootworm (Science)
• Microbial metabolism of food allergens (Cell Host Microbe)
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TWiM reveals the archaeal roots of eukaryotic life, and a building a gut malabsorption biosensor with bacteria.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

• The archaeal roots of eukaryotic life (PNAS)
• Building a malabsorption biosensor (Cell)
• Engineering gut biosensors with microbes (Natuer)
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TWiM discusses the use of bacteriophage-loaded microneedle patches for targeted and minimally disruptive foodborne pathogen decontamination, and a conjugal gene drive-like system that efficiently suppresses antibiotic resistance in bacteria.

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Links for this episode:

• Bacteriophage-loaded microneedle patches for food (Sci Adv)

• Gene drive to suppress antibiotic resistance (npj antimicrob and resistance)

• CRISPR gene drives (Syntego)

• Bier laboratory

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv