Nels and Vincent discuss molecular mimicry of a pathogen virulence target by a plant immune receptor.

Hosts: Nels Elde and Vincent Racaniello

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• Molecular mimicry of a pathogen virulence target by a plant immune receptor (Science)
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Nels – Plug-in solar
Vincent – This Engine Will Reinvent Space Travel

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Nels and Vincent discuss a chemically defined synthetic cell capable of growth and replication.

Hosts: Nels Elde and Vincent Racaniello

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• Chemically defined synthetic cell (bioRxiv)
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Nels – Jimothy the short spined racoon in Seattle
Vincent – Nitrogen-fixing organelle in a marine alga

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Science journalist Roxanne Khamsi joins Nels and Vincent discuss her first book, Beyond Inheritance, which explores how DNA continuously mutates throughout our lives, challenging the idea that our genetic destiny is fixed at birth.

Hosts: Nels Elde and Vincent Racaniello

Guest: Roxanne Khamsi

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• Beyond Inheritance (Amazon)
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Nels and Vincent discuss the development of a comprehensive transcriptomic atlas of early
embryogenesis from 61 animal species to understand the control of gene expression transitions from maternally deposited products to newly transcribed zygotic RNA.

Hosts: Nels Elde and Vincent Racaniello

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• Evolutionary landscapes of zygotic genome activation across animals (bioRxiv)
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Nels – Biologists Confirm Not Much Evolution Happened Today
Vincent – How Trains Take Electricity from Wires Without Breaking Contact

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Nels and Vincent discuss the discovery of a short RNA with the ability to catalyze its own synthesis.

Hosts: Nels Elde and Vincent Racaniello

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• A small polymerase ribozyme (Science)
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Nels – The University of Illinois Just Released a Popcorn So Good It Doesn't Need Butter
Vincent – Waste Wars: The Wild Afterlife of Your Trash by Alexander Clapp

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Nels and Vincent explain how stinkbug females smear fungus on their eggs to protect them from wasp parasitism.

Hosts: Nels Elde and Vincent Racaniello

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• Defensive fungal symbiosis on insect hindlegs (Science)
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Nels – Meet the Olympic superstar who trains under the radar in Utah
Vincent – The Discovery That Changed the Universe

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Nels and Vincent explain how selfishness evolved multiple times from an essential tRNA synthetase gene in a nematode.

Hosts: Nels Elde and Vincent Racaniello

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• Evolution of selfishness from a tRNA synthetase gene (Nat Ecol Evol)
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Nels - From Where Does it STEM?
Vincent - An Act of Cosmic Sabotage

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Nels and Vincent examines the use of AI and genome language models to design novel derivatives of bacteriophage phiX174.

Hosts: Nels Elde and Vincent Racaniello

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Nels – NIH official resigns after flap over risks of seasonal flu virus study and The Office of Science and Technology Policy (OSTP) requests input from all interested parties on Federal policy updates that aim to accelerate the American scientific enterprise, enable groundbreaking discoveries, and ensure that scientific progress and technological innovation benefit all Americans.
Vincent – One Plus One Equals One: Symbiosis and the evolution of complex life by John Archibald

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