エピソード

  • Mere suspicison is enough
    2025/07/17

    Nigel Wenham Thirwell https://lucyletbyinnocence.com/thirlwall-reviews-inspections-overview.html#n-wenham

    Dr Jayaram Thirwell. https://lucyletbyinnocence.com/thirlwall-doctors.html#r-jayaram

    Unherd: Hidden email raises doubts about Lucy Letby's verdict. https://unherd.com/newsroom/hidden-email-casts-doubt-on-lucy-letby-verdict/

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    52 分
  • Baby P: Death by Doctor
    2025/06/26
    The show trial of Lucy Letby: https://triedbystats.com/

    Show notes: https://docs.google.com/document/d/1luI6wmmHokOS8S_d2Br58Nj7kuiOsr4JI3TigMEW9gA/edit?usp=sharing

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    1 時間 1 分
  • Life The Universe and Everything More Thoughts on the Insulin Cases
    2025/06/18

    Show notes: https://docs.google.com/document/d/1MdXnrKFzXAScsNmudzpUUIDs3gDzmqCIg6v6y89bDDU/edit?usp=sharing

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    58 分
  • The Appalling medical treatment of Baby D
    58 分
  • Back to Biology
    57 分
  • St. Lucy of Letby
    2025/06/03

    Quick analysis of the Australian version of 60 minutes and critique of "criminology".

    Show notes

    https://docs.google.com/document/d/1O7eqIOmq8S4wyGsuRYxElI1GzJdy74CfDgoZTaMkNFg/edit?usp=sharing

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    1 時間 8 分
  • The Essential Lucy Letby
    2025/05/24

    Show notes: https://docs.google.com/document/d/10DOWpYi3XWQLTOrlLhiK0f2MBZfPuIz5l2lFk7UNYKg/edit?usp=sharing

    Chopin Nocturne in C# Minor https://www.youtube.com/watch?v=DqpPRj6UZqc

    Chopin Nocturne in C Minor https://www.youtube.com/watch?v=tSAwZP8e-zQ

    Beethoven, Adagio Cantabile, 2nd Movement Sonata Pathétique No. 8, op. 13 https://www.youtube.com/watch?v=BuN3yCmHb_U

    Franz Schubert - Piano Trio op.100 No.2 in Eb major 2nd Movement from the Soundtrack "The Hunger" ( David Bowie, Catherine Deneuve 1982) https://www.youtube.com/watch?v=DzehhFgI2MQ

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    56 分
  • The Fruit of The Poison Tree
    2025/05/20

    Phil's substack https://substack.com/@philedwards1

    Stuart Gilham's latest video: https://youtu.be/-VgH6OGa_1k?si=QUhhisncA2CdSpdk

    A single Roche Elecsys Immunoassay test for insulin and C-peptide is not a valid determinant of exogenous insulin administration in a preterm neonate due to several critical factors:

    The Roche Elecsys assay has not been validated explicitly for preterm neonates, a population with unique metabolic profiles due to immaturity. No studies have confirmed its accuracy, sensitivity, or specificity in this group, and reference intervals are based on general or adult populations.

    Preterm neonates exhibit significant variability in insulin and C-peptide levels due to factors like gestational age, insulin resistance, and transient hyperinsulinism.

    Without continuous monitoring, short-term peaks or troughs in insulin or C-peptide are missed, as studies only sample over hours or days. A single test cannot capture dynamic changes, risking misinterpretation of high insulin as exogenous when it could be a natural transient response.

    The assay can be affected by interferences (e.g., cross-reactivity with proinsulin or split products, and matrix effects in neonatal blood, which are not accounted for in preterm-specific validations, potentially skewing results.

    Even if a high insulin to low C-peptide ratio suggests exogenous insulin, preterm neonates can naturally have low C-peptide due to insulin deficiency or rapid clearance, alongside high insulin from resistance or stress. This overlap means the ratio is not a definitive indicator without context.

    https://pmc.ncbi.nlm.nih.gov/articles/PMC6056384/

    https://karger.com/neo/article/108/2/93/227641/Hyperglycaemic-Preterm-Babies-Have-Sex-Differences

    https://bmjpaedsopen.bmj.com/content/8/1/e002470

    https://bmjpaedsopen.bmj.com/content/1/1/e000160

    https://labogids.sintmaria.be/sites/default/files/files/c-peptide_2018-08_v10.pdf

    https://diagnostics.roche.com/global/en/products/lab/elecsys-c-peptide-cps-000460.html

    https://www.labcorp.com/tests/010108/c-peptide

    https://www.annlabmed.org/journal/view.html?doi=10.3343%2Falm.2018.38.6.530

    https://wwwn.cdc.gov/nchs/data/nhanes/public/2009/labmethods/ins_f_met_insulin_elecsys_2010_immunoassay.pdf

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    52 分