In this episode of Incubator India, Dr. Akanksha hosts Professor Dr. Shubha Phadke, a pioneer in medical genetics, to discuss the transformative role of Whole Exome Sequencing (WES) in neonatal care. The conversation covers the fundamentals of WES, its clinical applications, the importance of accurate phenotyping, and the utilization of genetic databases for effective diagnosis. Dr. Phadke emphasizes the need for high suspicion of genetic disorders in neonates and the critical role of detailed family history and clinical information in guiding genetic testing. This conversation delves into the critical role of genetics in neonatology, emphasizing the importance of rapid whole genome sequencing for early diagnosis and management of genetic disorders in neonates. It discusses the challenges posed by variants of unknown significance, the necessity of genetic counseling in the NICU, and the ethical dilemmas surrounding genetic testing and prenatal diagnosis in the Indian context. The conversation concludes with a call to empower clinicians with genetic knowledge to enhance patient care.

In this third episode of The Incubator India Podcast, hosts Dr. Anita Singh and Dr. Akanksha Verma dive into some of the latest research and break it down for our community of neonatologists in India. From hypertension in preterm neonates to the role of probiotics in NEC prevention, they break down five important studies with direct application in clinical practice. They explore the urgent need for standardized hypertension protocols, the surprising gaps in probiotic adoption, and whether blood gas analyzers can replace traditional CSF glucose testing. The discussion heats up as they examine India’s rubella vaccination campaign, uncovering both major successes and critical immunity gaps, before wrapping up with an in-depth look at vitamin K prophylaxis—does a higher dose offer real benefits?

Throughout the episode, Dr. Singh and Dr. Verma connect the dots between research and real-world practice, questioning how India can bridge the gap between data and daily neonatal care. With a sharp focus on evidence-based medicine, clinical impact, and policy evolution, this episode is a must-listen for anyone passionate about shaping the future of neonatology in India.

Tune in now for a fast-paced, insight-packed discussion that challenges the status quo!

The articles covered on today’s episode of the podcast can be found here

1. Das R, Nagpal R, Deshpande S, Kumar G, Singh A, Kallimath A and Suryawanshi P (2024) A survey on management practices of hypotension in preterm neonates: an Indian perspective.Front. Pediatr. 12:1411719.doi: 10.3389/fped.2024.1411719

2. More K, Hanumantharaju A, Amrit A, et al. (November 18, 2024) Use of Probiotics for Preventing Necrotizing Enterocolitis in Preterm Infants: A Survey of Current Practices Among Indian Neonatologists. Cureus 16(11): e73923.DOI 10.7759/cureus.73923

3. Jain A, Dutta S, Pal A, Kumar P. Neonatal CSF glucose measured by blood gas analyzer, glucometer, and standard laboratory methods. J Perinatol. 2024;44(12):1795-1799. doi:10.1038/s41372-024-02106-y

4. Anne RP, Kumar J, Kumar P, Meena J. Effect of oropharyngeal colostrum therapy on neonatal sepsis in preterm neonates: A systematic review and meta-analysis. J Pediatr Gastroenterol Nutr. 2024;78(3):471-487. doi:10.1002/jpn3.12085

5. Shanmugasundaram D, Viswanathan R, Winter AK, et al. Rubella immunity among pregnant women and the burden of congenital rubella syndrome (CRS) in India, 2022. Vaccine. 2024;42(24):126077.doi:10.1016/j.vaccine.2024.06.044

6. Natarajan AS, Delhi Kumar CG, Senthil Kumar GP, et al. One milligram versus two-milligram intramuscular vitamin K to prevent late-onset hemorrhagic disease in young infants: a randomized controlled trial. Indian Pediatr. 2025;62:116-20. doi: 10.1007/s13312-025-3374-6.

In the second episode of The Incubator India Podcast series, Dr. Akanksha Verma engages in a profound conversation with Surgeon Rear Admiral Professor Girish Gupta, a trailblazer in neonatology and early neonatal intervention. Currently leading the Department of Neonatology at Grafikira Institute of Medical Sciences, Dehradun, Professor Gupta draws on his 37 years of distinguished service in the Indian Armed Forces to share transformative insights into neonatal care.

This episode delves into the concept of early neonatal intervention, presenting it as a comprehensive approach that starts before conception and continues through antenatal, delivery, and postnatal periods. Professor Gupta discusses impactful practices such as delayed cord clamping, Kangaroo Mother Care (KMC), and multisensory integration, explaining how these strategies foster neurodevelopment, reduce stress, and optimize brain plasticity. He also underscores the importance of developmentally supportive NICU environments designed to minimize stress and support healing.

Highlighting the role of parents and innovative technologies, including artificial intelligence, Professor Gupta offers actionable advice for both healthcare professionals and families. This second episode continues to establish the podcast as a vital resource for advancing neonatal care, combining practical insights with inspirational guidance. Tune in for an enlightening exploration of strategies to ensure the best outcomes for newborns.