What if your smartwatch could detect illness four days before you feel symptoms? Dr. Michael Snyder, Stanford's pioneering geneticist and father of deep data profiling, has turned this science fiction into reality. And his groundbreaking work measures 135,000 biological markers compared to the mere 15 tests done in a typical doctor's visit.

In this mind-boggling conversation with Méline, Dr. Snyder shares how he discovered his own diabetes through genomic sequencing and continuous monitoring, catching it well before any doctor would have. His research reveals that we spend 11-15 years of our lives in poor health, but emerging technologies could change everything.

Most fascinating of all? Only 16% of your lifespan depends on genetics - the rest is lifestyle. Dr. Snyder's lab has proven that smartwatches can detect Covid with 80% accuracy, often days before symptoms appear, and that continuous glucose monitors will transform how you eat forever.

Listen in to discover:

How omics technology measures tens of thousands of molecules from blood and urine
Why different people age in completely different ways (age-types)
How your gut bacteria outnumber your human cells
Why fibre is the most underrated health intervention
The future of at-home health monitoring
"I believe with some re-engineering, we could probably have people live forever," Dr. Snyder explains, offering a glimpse into medicine's extraordinary future.

Subscribe to The HumanWare Project to join Méline Liu exploring the frontier where human potential meets cutting-edge technology.

**This content is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional before making any health or lifestyle changes.**

What if the brown, caramelised crust on your morning toast contained 50 new compounds that are literally accelerating your ageing? Dr. Pankaj Kapahi, a leading ageing researcher at the Buck Institute, has spent decades uncovering how seemingly innocent foods might be shortening our lives.

In this eye-opening conversation with Méline, Dr. Kapahi reveals the shocking truth about advanced glycation end products (AGEs) – toxic compounds formed when we cook food that make it tastier but trigger inflammation and premature ageing. His research on fruit flies has uncovered profound insights about human longevity, including why fibre should be your number one dietary priority.

Most startling of all? Women who experience puberty before age 11 and give birth before 20 face a staggering 400% increase in diabetes and obesity risk – revealing how early life events set the stage for how we age.

In this episode you'll hear all about:

Why cooking food creates 50 new ageing compounds in minutes
How intermittent fasting literally rewires your cellular clocks
Why muscle quality matters more than muscle mass
The optimal age for women to have children (around 30)
Why people kept in constant darkness might live longer
"It's more important to have more life in your years than to have more years in your life," Dr. Kapahi says, offering a profound new perspective on what healthy ageing really means. Listen in for more!

Subscribe to The Humanware Project to join Méline Liu exploring the frontier where human potential meets cutting-edge technology.

**This content is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional before making any health or lifestyle changes.**

Step inside the laboratory where the future of human longevity is being written. In this exclusive behind-the-scenes tour, Méline visits Generation Lab with co-founder Alina Rui Su a Harvard-trained scientist and Forbes 30 Under 30 entrepreneur, alongside pioneering researchers Dr. Irina and Dr. Michael Conboy.

From million-dollar flow cytometry machines that analyse ageing at the single-cell level to automated microscopes capturing cellular transformation in real-time, this lab houses the cutting-edge technology turning 20 years of groundbreaking science into real-world treatments. The Conboys reveal how their famous parabiosis experiments – surgically connecting young and old mice – led to the revolutionary discovery that aging might be reversible.

Most fascinating of all? Their work on 'immortal DNA' shows how stem cells can distinguish between old and new genetic material, keeping the freshest copies for themselves whilst passing worn versions to daughter cells.

In this episode you'll discover:

How million-dollar machines detect cellular aging in real-time
The romantic story behind one of science's greatest partnerships
Why parabiosis isn't just about blood sharing
The 'immortal DNA' mechanism that could revolutionise medicine: https://pmc.ncbi.nlm.nih.gov/articles/PMC1852584/
How Generation Lab is turning research into accessible treatments

"Take care of science and science will take care of you," Dr. Irina Conboy explains, embodying the passion driving this revolutionary work.

Subscribe to The HumanWare Project to join Méline Liu exploring the frontier where human potential meets cutting-edge technology.

**This content is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional before making any health or lifestyle changes.**

For over a century, medicine has treated the female body as a mystery – one that Dr. Jennifer Garrison is finally solving. As a pioneering neuroscientist studying brain-body communication, she's uncovered a startling truth: if we could understand female ageing, we could solve all of human ageing.

In this eye-opening conversation with Méline, Dr. Garrison reveals how ovaries age up to 2.5 times faster than other organs, creating a health crisis that affects every woman. But her most fascinating discovery? Your brain operates its own 'Wi-Fi system' – wireless chemical signals that control everything from sleep to reproduction.

Dr. Garrison exposes the shocking reality that, until 1993, most clinical studies excluded women entirely, leaving us practising medicine with only half the knowledge. The result? Women live longer but spend 25% more time in poor health than men.

In this episode you'll discover:

How ovaries act as 'architects of health' throughout your entire life
Why 135+ symptoms plague women during perimenopause
The revolutionary tissue transplant experiments extending lifespan
Why current hormone therapy feels like 'a sledgehammer'
How female health represents a $14 billion untapped market
"We have been underserved as a population for a century," Dr. Garrison explains. "I can't think of anything more important that I could work on as a scientist than to try to understand how to fix this."

Subscribe to The HumanWare Project to join Méline Liu exploring the frontier where human potential meets cutting-edge technology.

*This content is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional before making any health or lifestyle changes.*

Deep inside your brain's memory centre, something extraordinary is happening that scientists are only just beginning to understand. Dr. Ashley Webb – a leading neuroscientist at the Buck Institute and scientific co-founder of Bolden Therapeutics – has uncovered a shocking discovery about how male and female brains age in fundamentally different ways.

In this fascinating conversation with Méline, Dr. Webb reveals her groundbreaking research on the hippocampus, our brain's GPS system. Her most startling finding? Female brains undergo dramatic changes on the X chromosome during ageing that simply don't occur in males – potentially explaining why women are disproportionately affected by Alzheimer's disease.
But there's hope. Dr. Webb's research shows our brains can regenerate throughout life, creating brand new neurons through neurogenesis.
In this this episode you'll discover:

Why finding your car is actually a sophisticated test of brain health
How new blood tests can detect Alzheimer's decades before symptoms appear
Why voluntary exercise literally grows new brain cells
How chronic stress destroys memory formation
The effects of neural stem cell decline
The brain's quality control systems that clear cellular damage

"The brain can actually regenerate itself to some extent," Dr. Webb explains. "The dogma has always been no new neurons – but it turns out that's very likely to be untrue. And here's why..."
Subscribe to The HumanWare Project to join Méline Liu exploring the frontier where human potential meets cutting-edge technology.

**This content is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional before making any health or lifestyle changes.**

The quest to reverse ageing led Dr. Irina Conboy to a startling discovery: after connecting young and old mice together in a groundbreaking experiment, she found that, not only did the old mice become younger, but the young mice prematurely aged. This revelation sparked a revolutionary insight: ageing isn't about lacking something that young blood provides, but rather accumulating too much of certain proteins.

In this brilliant conversation with Méline, Dr. Conboy explains how her research at Generation Lab has evolved from those early experiments to a promising new therapeutic drug. Unlike controversial "young blood" therapies, her approach focuses on diluting the excess proteins that accumulate with age – essentially "changing the water in the fish tank" of our bodies.

The most powerful revelation? Young blood is not the miracle cure many believe it to be. In fact, Dr. Conboy's research shows that simply removing 50% of blood plasma can be far more rejuvenating than adding young blood – and without the significant health risks of repeated plasma exchange procedures.

Listen in to discover:

Why noise and dysregulation in our biological systems may be the true markers of ageing
How different organs age at varying rates, creating unique "biological age" profiles
The critical transition points in ageing that occur around ages 25-27 and 40
Why rapamycin and metformin may not be the miracle anti-ageing drugs many claim
How Generation Lab's new drug, extended mice lifespans by an astonishing 73%
Through Dr. Conboy's pioneering research, we glimpse a future where human lifespan could extend by an additional 40 years – not just living longer, but remaining active and vibrant well beyond our current expectations. Her work suggests the possibility of resetting our biological clocks without resorting to unproven or risky interventions.

Subscribe to The HumanWare Project to join Méline Liu exploring the frontier where human potential meets cutting-edge technology.

**This content is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional before making any health or lifestyle changes.**

Standing at a career crossroads, Ben Woodington faced a pivotal decision: pursue AI applications in healthcare, or dive into the then-nascent field of neurotechnology. His choice to develop tiny electronic implants for the human brain was driven by a profound question: which technologies would transform healthcare most dramatically over the next two decades?

In this eye-opening conversation with Méline, Ben reveals how his company Coherence Neuro is developing revolutionary brain-computer interfaces (BCI) that could transform disease treatment. Their first product, Soma 1 - a device smaller than a coin implanted flush with the skull – can deliver electrotherapy alongside detecting unique electrical signatures of cancer cells, creating an entirely new field of neural biomarkers.

The most powerful revelation? Our bodies' electrical activity underpins nearly every biological process, including cancer. By measuring these signals and stimulating tissues electrically, Ben's platform neurotechnology opens up remarkable new treatment possibilities beyond what drugs alone can achieve.

In this fascinating episode, discover:

· Why BCI don't always require invasive implants
· How tiny implantable devices can detect cancer progression through electrical signatures
· The surprising ways electrical stimulation can treat diseases beyond brain disorders
· Why the scientific hurdles have largely been solved, leaving engineering, clinical and ethical challenges
· The profound questions we'll face as the boundaries between humans and machines continue to blur

As Ben notes, "The complete merging of machine data and human beings is going to solve a lot of our problems and diseases. That's super exciting to me. We've never had anything like that in the history of humankind."

Through Ben's expert perspective, we glimpse a near future where our understanding of electrical biology transforms healthcare - and potentially what it means to be human. A world where devices smaller than a fingernail can extend our lives, where cancer becomes a manageable condition through electronic treatment and monitoring, and where we must navigate the complex ethical terrain of becoming intimately connected to our technology.

Subscribe to The HumanWare Project to join Méline Liu exploring the frontier where human potential meets cutting-edge technology.

**This content is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional before making any health or lifestyle changes.**

What if preventative health isn't something that happens after work, but flows through your entire day? For Bulëza Koci, this approach is transforming how leaders optimise their performance.

In this conversation with Méline, Bulëza reveals how her experience in integrated cancer therapies sparked her mission to help high-performers through data-driven, personalised strategies. As founder of the Dream Health programme, she explains how leaders can apply elite athlete principles to business performance.

The key insight? Recovery isn't a luxury – it's essential technology for peak performance. Like athletes who schedule recovery as deliberately as training, today's leaders must master nervous system regulation to avoid burnout. Understanding the crucial difference between sympathetic (fight-or-flight) and parasympathetic (rest-and-digest) states, and learning to shift between them, is the foundation of sustainable high performance.

In this fascinating episode, discover:

Why muscle mass is critical for longevity and resilience against disease
How to identify your natural biorhythms and structure your day accordingly
Practical techniques to activate your vagus nerve and shift from stress to recovery
Why inflammation markers are crucial indicators of overall health
Simple morning rituals that can transform your entire day
Through Bulëza's expertise, we glimpse a future where preventative health isn't about quick fixes, but understanding your unique biology and creating sustainable practices for lasting performance.

Subscribe to The HumanWare Project to join Méline Liu exploring the frontier where human potential meets cutting-edge technology.

**This content is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional before making any health or lifestyle changes.**