NAD+ is usually described as something you run out of. JP Errico explains why that's backwards: you don't stop making it, you burn through it — and inflammation is what's doing the burning.

In this episode, we cover what NAD+ actually does beyond energy production, why sirtuins can't function without it, and how CD38 on activated immune cells consumes NAD+ by the thousands of molecules. JP walks through SIRT1 and its control over NF-κB, PGC-1α and FOXO3; SIRT3's role in mitochondrial protein folding and heat shock proteins; and SIRT6's work in DNA damage repair.

We also get into a CD38 vaccine coming out of China, how your body packages the NAMPT recycling enzyme into exosomes and ships it to the cells that need it while you sleep, where urolithin A and methylene blue fit, and why no supplement can out-run a broken circadian rhythm.

JP closes with the four root causes of aging — mitochondrial electron transport chain malfunction, chronic NF-κB activation, AMPK and mTOR imbalance, and NAD+ depletion — and why every one of them is reversible.

In this episode, we discuss:

• Why NAD+ decline is a consumption problem, not a production problem
• PARP1, CD38, and what's actually draining the tank
• What sirtuins do, and why they stop working without NAD+
• SIRT1, SIRT3, SIRT6 — and which has the best longevity data
• NMN vs NR: why the debate matters less than you think
• Sleep, fasting, heat and exercise as the foundation
• The four reversible root causes of aging
• How perception changes whether a challenge ages you or strengthens you

Dr. Navaz Habib

Email: podcast@healthupgraded.com
Facebook: https://www.facebook.com/DrNavazHabib/
Instagram: https://www.instagram.com/drnavazhabib/
LinkedIn: https://ca.linkedin.com/in/drnavazhabib

JP Errico
Instagram: https://www.instagram.com/thevnsguy/
LinkedIn: https://www.linkedin.com/in/jp-errico-097629aa

In this episode of the Health Upgrade Podcast, we are joined by Coach Debbie Potts, who shares her personal journey from being a high-performing Ironman athlete to facing unexpected health challenges. Debbie opens up about her experiences with burnout, weight gain, and fatigue, highlighting how even those doing "all the right things" can still struggle when chronic stress goes unmanaged.

The conversation dives deep into the concepts of metabolism, stress accumulation, and recovery. We discuss the importance of balancing stressors with adequate rest, the role of the vagus nerve and heart rate variability, and how too much of a "good thing" (exercise, fasting, or even biohacking habits) can push anyone into "metabolic chaos" if recovery is neglected.

If you're a high performer or simply looking to better understand your body's signals, this episode offers actionable insights and a fresh perspective on health. Share the episode with friends and be sure to follow for more tips on upgrading your metabolism and fostering real recovery in your life!

Dr. Navaz Habib

Email: podcast@healthupgraded.com
Facebook: https://www.facebook.com/DrNavazHabib/
Instagram: https://www.instagram.com/drnavazhabib/
LinkedIn: https://ca.linkedin.com/in/drnavazhabib

JP Errico
Instagram: https://www.instagram.com/thevnsguy/
LinkedIn: https://www.linkedin.com/in/jp-errico-097629aa

Coach Debbie Potts
Website: https://debbiepotts.net/
Instagram: https://www.instagram.com/coachdebbiepotts/

In this episode of the Health Upgrade Podcast, I dive into the growing epidemic of blood sugar dysregulation and type 2 diabetes, breaking down why these issues have become so prevalent. I explain how genetics, lifestyle, stress, sleep, and even our gut microbiome all play a critical role in blood sugar regulation, not just the foods we eat. From genetic markers to the impact of adverse childhood events, I highlight the interconnectedness of our environment and our metabolic health.

You will learn about effective strategies for blood sugar management, from optimizing meal timing and movement to choosing the best evidence-backed diets and supporting gut health. I share simple, actionable tips like walking after meals, prioritizing quality sleep, and building consistent exercise routines, emphasizing that consistency, not perfection, is the key to long-term results.

If you found these insights helpful, please share this episode with friends who might benefit from a health upgrade too! Let’s work together to make small, sustainable changes for better health!

Dr. Navaz Habib

Email: podcast@healthupgraded.com
Facebook: https://www.facebook.com/DrNavazHabib/
Instagram: https://www.instagram.com/drnavazhabib/
LinkedIn: https://ca.linkedin.com/in/drnavazhabib

In this episode of the Health Upgrade Podcast, I dive into the science behind doomscrolling, from why we get stuck endlessly on our phones late at night to what’s really happening inside our brains and bodies during those scrolling marathons. I explore the neuroscience of decision fatigue, explain how our visual systems and nervous states are affected, and uncover how screen habits send us into stress mode instead of helping us truly wind down.

One concept discussed was the powerful link between our visual focus and nervous system state, illustrating how narrowing our gaze on our phones turns off the calming vagus nerve and ramps up stress hormones. I also share practical strategies like the 20-20-20 rule, physiologic sigh breathing, and creating tech boundaries in the evening to support better sleep and healthier habits.

If you found this episode helpful, please share it with a friend who might benefit! Don’t forget to rate the podcast and consider joining the free Health Upgraded community for more resources and weekly support. Upgrade your evenings, break the doom scrolling cycle, and give your body the healthy rest it deserves!

Dr. Navaz Habib

Email: podcast@healthupgraded.com
Facebook: https://www.facebook.com/DrNavazHabib/
Instagram: https://www.instagram.com/drnavazhabib/
LinkedIn: https://ca.linkedin.com/in/drnavazhabib

In this special “Ask Us Anything #2” episode of the Health Upgrade Podcast, Valerie Driscoll and Sara Tate join me to answer questions from our Health Upgraded community.

We talk about what can happen when you start vagus nerve stimulation too early and why it’s important not to introduce too many new treatments or tools before your body is ready.

We also discuss the importance of checking the basics first, including digestion, bowel movements, hydration, stress levels, and healthy ways to cope with stress. Before trying more advanced tools like stimulators or cold plunges, it’s important to make sure your body has a strong foundation.

If you enjoyed the conversation, share the episode with someone who might find it helpful. Remember, good health starts with getting the basics right before adding more to your routine.

Dr. Navaz Habib

Email: podcast@healthupgraded.com
Facebook: https://www.facebook.com/DrNavazHabib/
Instagram: https://www.instagram.com/drnavazhabib/
LinkedIn: https://ca.linkedin.com/in/drnavazhabib

In this episode of the Health Upgrade Podcast, we are joined by John Hacker, founder of NeurGear and creator of the ZenBud ultrasound vagus nerve stimulator. The conversation covers the science behind vagus nerve stimulation, comparing technologies like ultrasound and electrical stimulation, and exploring their therapeutic applications in areas such as mental health, stress, and chronic pain.

Together, we dive into the challenges and controversies in the world of bioelectronic medicine, highlighting the impact of the medical and wellness industries, regulatory hurdles, and the importance of usability and patient compliance. We discuss real-world stories, clinical outcomes, and the crucial role of personalized care in ensuring sustainable health improvements through technology.

If you're intrigued by the future of health technology and want to discover how vagus nerve stimulation could benefit you or someone you know, this episode is packed with actionable insights. Share this episode with friends, and remember to follow the show so you never miss an update on cutting-edge health strategies!

Dr. Navaz Habib

Email: podcast@healthupgraded.com
Facebook: https://www.facebook.com/DrNavazHabib/
Instagram: https://www.instagram.com/drnavazhabib/
LinkedIn: https://ca.linkedin.com/in/drnavazhabib

JP Errico
Instagram: https://www.instagram.com/thevnsguy/
LinkedIn: https://www.linkedin.com/in/jp-errico-097629aa

Jon Hacker
LinkedIn: https://www.linkedin.com/in/jon-hacker/

In this episode, I dive into the world of cold plunges, breaking down the science, the hype, and what really matters for your health. We discuss the latest research on cold exposure, including its impact on stress, recovery, resilience, and neurochemistry. But the key takeaway? It’s not just about how cold the water is! A big part of the benefits comes from how you breathe during the process.

I highlight when cold immersion can be helpful and who needs to exercise caution or avoid it altogether. There’s special emphasis on individual capacity, differences between men and women, and practical ways to get the benefits without going to extremes. For anyone considering cold plunges or cold showers, it’s essential to listen to your body and focus on breathing, not just temperature.

Loved this episode or know someone curious about cold plunges? Share it with a friend who could benefit from understanding the real science behind this health trend! If you want more tips and want to join our community, check out healthupgraded.com. Don’t forget to follow so you never miss an episode that could help you upgrade your health!

Dr. Navaz Habib

Email: podcast@healthupgraded.com
Facebook: https://www.facebook.com/DrNavazHabib/
Instagram: https://www.instagram.com/drnavazhabib/
LinkedIn: https://ca.linkedin.com/in/drnavazhabib

In this episode of the Health Upgrade Podcast, we are joined by Dr. Dana Johnson, a leading expert in occupational therapy and whole-body apraxia. Together, we explore the often-misunderstood world of autism, focusing on the challenges of motor planning, sensory processing, and the brain-body disconnect that affects so many individuals and their families.

Dr. Dana Johnson shares her journey into the field, highlighting the importance of understanding apraxia beyond speech, and shines light on how intentional movement, regulation, and small lifestyle changes can significantly improve outcomes for people with autism. The conversation also covers the roles of gut health, mitochondrial function, and parental co-regulation, offering real-world strategies and hope for families facing these daily struggles.

If you know someone impacted by autism or are seeking approachable, science-backed strategies to help loved ones, this episode is a must-listen. Don’t forget to share it with someone who would benefit. Let’s build a more supportive and informed community together!

Dr. Navaz Habib

Email: podcast@healthupgraded.com
Facebook: https://www.facebook.com/DrNavazHabib/
Instagram: https://www.instagram.com/drnavazhabib/
LinkedIn: https://ca.linkedin.com/in/drnavazhabib

JP Errico
Instagram: https://www.instagram.com/thevnsguy/
LinkedIn: https://www.linkedin.com/in/jp-errico-097629aa

Dr. Dana Johnson
Website: https://drdanajohnson.com/