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The Health Edge: translating the science of self-care

The Health Edge: translating the science of self-care

著者: Mark Pettus MD and John Bagnulo PhD MPH
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“It’s not what we don’t know that gets us into trouble. It’s what we know that ain’t so”.

Will Rogers


We believe the explosion of life science research from many disciplines had catapulted ahead of our capacity to process, integrate, understand, and apply. We are interested in translating all that is out there as news to use. A fundamentally different understanding of human biology has emerged. The implications from the perspective of self-care are profound. We are rapidly moving away from the debate of nature versus nurture toward an understanding that life emerges from a dynamic landscape of nature via nurture.

We are passionate about the science. We are passionate about the implications. We believe in the capacity and possibility made possible by being alive here and now! We are beautifully designed to be on the African Savannah, living fully integrated with our planet, and in the context of social relationship. Our modern environment is not well designed to promote human health and the capacity to thrive. Many are struggling to maintain balance and traction in lives that often feel overwhelming and frightening.The challenge is to better leverage our superb ancestral adaptation for a different and radically challenging modern environment. Everything that touches us today has the potential be be very familiar or totally foreign. The less aware one is of the day to day distance between what we are biologically , as a species, “familiar with” and what we actually encounter, the fewer the possibilities for more effective alignment.

Leaving one’s health trajectory to chance in our modern environment is a very risky proposition. We are interested in holding the science to the light with an open and humbled mindset. Like you, We are intrepid explorers interested in how we emerge in the midst of our relationship with the environmental inputs of our lives…how we eat, how we move, how we sleep, how we navigate the mind fields of conflict in our lives, how socially connected we are, how we manage the burden of environmental toxins in our lives, how much meaning we cultivate in our work, love, play and how we interpret and respond to stress in our lives. We will drill deep, share all that my experiences has taught and do all that we can to create value for you as you seek to find your health edge. We always welcome your feedback.

Mark and John

© 2025 The Health Edge: translating the science of self-care
代替医療・補完医療 衛生・健康的な生活 身体的病い・疾患
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  • How Exercise Intensity Shapes Longevity, Heart Health, And Metabolic Resilience
    2025/12/17

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    A minute that leaves you breathless can rival eight minutes of comfortable effort. That’s the eye-opening takeaway we unpack as we dive into fresh UK Biobank data showing how vigorous activity dramatically outperforms moderate and light movement for reducing all-cause mortality, cardiovascular events, diabetes, and even cancer risk. We strip away jargon and use the talk test—can you sing, speak, or barely get a sentence out?—so anyone can gauge intensity without a lab or a smartwatch.

    We explore why intensity pays off under the hood: stronger left ventricular function, bigger stroke volume, better oxygen delivery, improved lactate recycling, greater capillary and mitochondrial density, and faster glycogen turnover. Then we get practical. No fancy gear required—try telephone-pole intervals on a walk, short hill surges, a flight of stairs at speed, or breathless bursts during yardwork and shoveling. Keep light movement threaded through your day to counter the stress signals of sitting, but add slim, safe slices of intensity to unlock outsized benefits when time is tight.

    We also lay out a sane progression. Find a steady state before nudging harder, start with tiny intervals, and build toward an 80 percent moderate base with 10 to 20 percent vigorous effort. Fold in resistance training to protect muscle, strength, and glucose control. The goal isn’t punishment; it’s leverage—using a few honest minutes to gain more health per unit of time. If you’ve ever wondered how to make movement matter more, this conversation offers a clear path you can start today. If it helps, share it with a friend, subscribe for more science-backed self-care, and leave a review to tell us your first vigorous minute.

    For video, PowerPoint slide deck and reference studies go to www.thehealthedgepodcast.com

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    54 分
  • Coffee, AFib, And What The Science Says
    2025/12/11

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    Coffee and heart rhythm don’t have to be enemies. We dig into a new randomized trial across the US, Canada, and Australia suggesting that caffeinated coffee may lower the risk of recurrent atrial fibrillation compared with abstaining, then connect the dots with real-world monitoring, ablation strategy, and day-to-day choices that influence heart health.

    We start by grounding AFib in plain terms: what it is, why so many people never feel it, and how stroke risk rises when the atria stop driving a steady beat. From there, we step into the electrophysiology lab to explain why trouble often starts near the pulmonary veins and how clinicians map and ablate rogue electrical tissue. Along the way, we highlight the role of wearables like Apple Watch in catching silent arrhythmias and guiding decisions, a shift that is rapidly improving detection and management outside the clinic.

    Then we unpack the DECAF trial’s headline: coffee drinkers showed meaningfully lower recurrence of AFib or flutter over six months versus those who abstained. We explore possible reasons, from caffeine’s adenosine receptor antagonism and calcium signaling effects to the antioxidant and mitochondrial support offered by coffee’s polyphenols. We also compare with NEJM data in the general population showing no significant increase in ectopy, putting fears into perspective. Finally, we get practical: dosing and timing to protect sleep, what brewing methods change, how dairy proteins can blunt polyphenol absorption, and when unfiltered versus filtered makes sense if you’re balancing lipids and antioxidants.

    If you enjoy coffee and live with AFib, these insights can help you personalize your cup without losing sight of the fundamentals: anticoagulation when indicated, smart rate or rhythm control, and balanced training that avoids chronic overload. If this conversation helps you think differently about caffeine, subscribe, share with someone who cares about heart health, and leave a review so others can find it.

    For powerpoint slide deck, video recording and reference open-source articles go to: www.thehealthedgepodcast.com

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    35 分
  • The Delicate Balance Between Oxidative Stress And Antioxidants
    2025/12/03

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    Most wellness advice tries to stamp out oxidative stress. We make a different case: the right dose of stress is the signal that builds resilience. From the first snowfall chat to a deep dive on electrons, mitochondria, and energy flow, we walk through how redox balance—reduction and oxidation—is the unseen driver of better fitness, metabolism, and healthy aging. Rather than drowning your cells in pharmacologic antioxidant doses, we show why whole foods, intelligent training, and hormetic practices switch on the body’s superior, built-in defenses.

    We break down how reactive oxygen species act as messengers that activate NRF2 and tune NF kappa B, leading to stronger antioxidant enzymes like superoxide dismutase, catalase, and glutathione. You’ll hear why studies on high-dose vitamin A, E, and isolated polyphenols have disappointed or even backfired, and how funding bias confuses the supplement hype cycles. We connect these insights to practical levers: balancing training intensity to avoid chronic overreach, using time-restricted eating to spur ketone-driven repair, and introducing sauna, cold exposure, and real daylight to enhance mitochondrial function and recovery.

    Food-first takes center stage. We discuss the risks of seed oils and excessive polyunsaturated fats on membrane stability and oxidative load, plus simple swaps toward olive oil, avocado, and nutrient-dense whole foods. Micronutrients like selenium, zinc, and sulfur amino acids matter because they power your endogenous antioxidant systems. The goal isn’t to smother the flame; it’s to keep a steady candle that signals adaptation without tipping into a wildfire. We close with a n=1 approach—listen to energy, sleep, and training feedback—and small experiments that reveal your best balance.

    If this resonated, follow the show, share it with a friend who loves the science of training and longevity, and leave a quick review so more listeners can find us.

    For video, open access reference papers and PP slide deck go to: www.thehealthedgepodcast.com

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    52 分
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