Back in the 1980s, when Shimon Sakaguchi was a young researcher in immunology, he found it difficult to get his research funded. Now, his pioneering work which explains how our immune system knows when and what to attack, has won him a Nobel prize.

Sakaguchi, along with American researchers Mary Brunkow and Fred Ramsdell, were jointly awarded the 2025 Nobel prize in physiology or medicine for the work on regulatory T-cells, known as T-regs for short, a special class of immune cells which prevent our immune system from attacking our own body.

In this episode Sakaguchi tells The Conversation about his journey of discovery and the potential treatments it could unlock.

This episode was produced by Mend Mariwany, Katie Flood and Gemma Ware. Sound design and mixing by Michelle Macklem and theme music by Neeta Sarl. Read the full credits for this episode and sign up here for a free daily newsletter from The Conversation.

If you like the show, please consider donating to The Conversation, an independent, not-for-profit news organisation.

• Metal-organic frameworks: Nobel-winning tiny ‘sponge crystals’ with an astonishing amount of inner space
• Nobel physics prize awarded for pioneering experiments that paved the way for quantum computers
• How does your immune system stay balanced? A Nobel Prize-winning answer
• Nobel medicine prize: how a hidden army in your body keeps you alive – and could help treat cancer

As Donald Trump gives oxygen to unproven theories about what might be behind a recent rise in autism cases, experts repeatedly point to the changing nature of how autism is diagnosed and viewed.

A key moment in the history of autism diagnosis was the publication in 1994 of a new version of the Diagnostic and Statistical Manual of Mental Disorders. It's a reference book of psychiatric conditions and how to diagnose them, used by psychiatrists and psychologists around the world.

In this episode, Andrew Whitehouse, a professor of autism research at the University of Western Australia, explains why this shift in autism diagnosis happened in the 1990s, what impact it had, and what it's meant for the support autistic people get.

This episode was produced by Katie Flood, Mend Mariwany and Gemma Ware. Sound design and mixing by Michelle Macklem and theme music by Neeta Sarl. Read the full credits for this episode and sign up here for a free daily newsletter from The Conversation.

If you like the show, please consider donating to The Conversation, an independent, not-for-profit news organisation.

Donald Trump is not letting up pressure on the US Federal Reserve. He's taken efforts to fire one of its governors, all the way up to the US Supreme Court.

Trump's clash with the Fed echoes pressure that Richard Nixon put on the central bank in the 1970s to lower interest rates. In this episode, Cristina Bodea, professor of political science at Michigan State University, why that moment – and the inflation spike that followed – became a cautionary tale about what can happen if politicians threaten the independence of central banks.

This episode was written and produced by Katie Flood and Gemma Ware with assistance from Mend Mariwany. Sound design and mixing by Eloise Stevens and theme music by Neeta Sarl. Read the full credits for this episode and sign up here for a free daily newsletter from The Conversation.

If you like the show, please consider donating to The Conversation, an independent, not-for-profit news organisation.