Applyo Jena is building a freeze-dried future, one bead at a time. In this episode, Dr. Hanno Hermann and Dr. Thanh Tu Hellmich-Duong walk us through how their lyo-bead technology emerged from the challenges of field-based HIV diagnostics and evolved into a flexible platform that stabilizes everything from enzymes to magnetic nanoparticles, without the need for refrigeration.

From diagnostics research to therapeutics, this lyophilization platform is solving key pain points in reagent formulation, shipping, and field use. Hanno and Thanh Tu explain how lyo-beads offer precise, single-use reagent doses with near-instantaneous rehydration, minimal batch-to-batch variability, and extended ambient temperature stability. Whether it's for isothermal RT-LAMP, next-gen sequencing prep, or phage-based application, Applyo’s platform unlocks new formats, simplifies logistics, and lowers the environmental burden of molecular workflows.

With new hires, new markets, and new product lines on the horizon, Applyo Jena is poised for a decade of growth and maybe even a hand in reshaping the way freeze-dried pharmaceuticals are developed and delivered.

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Visit the Invitrogen School of Molecular Biology to access helpful molecular biology resources and educational content, and please share this resource with anyone you know working in molecular biology.

For Research Use Only. Not for use in diagnostic procedures.

In this Mol Bio Minutes episode, Thermo Fisher Scientific’s Monika Jazdauskaitė dives into the versatile world of Recombinase Polymerase Amplification (RPA). Unlike PCR, RPA operates at a constant, low temperature (around 37–42°C), enabling fast, equipment-light workflows that are ideal for field diagnostics and decentralized labs. Monika explains how the method works and why RPA is emerging as a go-to technique for both DNA and RNA target detection.

She highlights RPA’s specificity, sensitivity, and robustness against common inhibitors like ethanol and heparin, critical for applications like respiratory pathogen detection or low-quality sample inputs. Plus, she shares how RPA’s gentle conditions and lyophilization compatibility make it a strong candidate for stabilizing next-generation sequencing (NGS) libraries, especially those with high GC content.

Whether you're looking to simplify pathogen detection or streamline your sequencing prep, RPA offers a compelling alternative to traditional amplification. And with ready-to-use kits like the Invitrogen™ Lyo-ready RPA Kit, Thermo Fisher is helping researchers bring speed and stability to molecular workflows, all with no thermal cycler required.

Subscribe to get future episodes as they drop and if you like what you’re hearing we hope you’ll share a review or recommend the series to a colleague. 

Visit the Invitrogen School of Molecular Biology to access helpful molecular biology resources and educational content, and please share this resource with anyone you know working in molecular biology.

For Research Use Only. Not for use in diagnostic procedures.

In this episode of Speaking of Mol Bio, Dr. Andre Ghetti, CEO of AnaBios, offers a deep dive into the world of translational preclinical research. AnaBios is redefining early human insights by using ethically sourced, functional human tissues and cells to generate actionable data before compounds ever enter clinical trials. Ghetti walks us through the company’s approach of offering human-relevant safety and efficacy data, validating drug targets, and supporting everything from small startups to major pharma groups.

We learn how AnaBios engages with clients to customize assays, especially in high-need areas like non-opioid pain therapies, fibrosis, and cardiac safety, and how they use a blend of standardized and novel functional assays, some of which required building their own hardware. He also discusses their integration of RT-PCR, RNA-seq, and calcium imaging, including genetically encoded sensors to monitor neuronal activity at scale.

From their use of machine learning to analyze massive data sets, to collaborations with the FDA, to their unique ability to preserve tissue viability across the U.S., AnaBios offers a powerful glimpse into the future of translational biology. Dr. Ghetti also shares advice for young scientists and reflects on what’s next for AnaBios, including oncology and stem-cell model integration.

Subscribe to get future episodes as they drop and if you like what you’re hearing we hope you’ll share a review or recommend the series to a colleague. 

Visit the Invitrogen School of Molecular Biology to access helpful molecular biology resources and educational content, and please share this resource with anyone you know working in molecular biology.

For Research Use Only. Not for use in diagnostic procedures.