The drug was right. The culture said susceptible.
But the patient didn’t improve.

In this episode, we reveal the real reason antimicrobial therapy fails:
You didn’t match the drug’s kill style to the dosing strategy.

🔍 Learn:

• The difference between time-dependent and concentration-dependent killing
• Key PK/PD metrics like Time > MIC, Cmax/MIC, and AUC/MIC
• Why some antibiotics demand frequent small doses while others want big hits
• How drug class, site of infection, and patient physiology change your strategy
• Common pitfalls that lead to treatment failure or resistance

🎯 Includes a board-style question and flashcard-style recap.

🎧 Built for surgical residents.
Feedback or requests? Carl Damiani (cd@simini.com)

You picked the right drug. The culture said susceptible.
And the infection still got worse.

It’s not always resistance — sometimes, it’s you.

In this episode, we break down how antimicrobials actually kill — and why understanding that is the key to board success and clinical results.

You’ll learn:

• The difference between bactericidal and bacteriostatic drugs
• The mechanisms of action for the major antimicrobial classes
• Why folic acid synthesis inhibition is a double-drug strategy
• How to choose the right kill style for the right patient
• Time-dependent vs. concentration-dependent antibiotics

Includes a board-style question + flashcard-style recap.

🎧 Built for surgical residents.
Feedback or requests? cd@simini.com

In this episode, we break down one of the most misunderstood principles in fracture repair: what role your implant is actually playing.

Is it carrying all the load? Or sharing it with the bone?
Because if you mismatch your construct to the fracture — it’s not if it will fail. It’s when.

🔍 You’ll learn:

• The difference between load sharing and load bearing
• What happens when implants are too stiff or too weak
• When to use bridging vs. compression
• Why implant selection = healing environment
• Common board traps, like over-stiff constructs and stress shielding

Includes a board-style question + flashcard recap. Built for residents.

🎧 Listen while commuting, scrubbing in, or running with your dog.

Feedback? Ideas for the next episode? cd@simini.com