『Science in Real Time (ScienceIRT)』のカバーアート

Science in Real Time (ScienceIRT)

Science in Real Time (ScienceIRT)

著者： Araceli Biosciences
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 Science in Real Time (ScienceIRT) podcast serves as a digital lab notebook—an open-access, conversational platform that brings the stories behind cutting-edge life science tools and techniques into focus. From biologics to predictive analytics and AI-powered innovation, our guests are shaping the future of therapeutic discovery in real time.2025 Araceli Biosciences 生物科学 科学 経済学
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  • Molecule Talk - CellCLIP: When Cell Painting Meets AI and Natural Language

    Molecule Talk - CellCLIP: When Cell Painting Meets AI and Natural Language
    2025/09/25

    In this Molecule Talk episode, host Carli Reyes explores CellCLIP, a provocative new approach at the intersection of high-content imaging and AI. Based on a June 2025 preprint, CellCLIP attempts to link Cell Painting images with natural language descriptions of perturbations, making cellular data more interpretable, searchable, and useful across disciplines. While still preliminary and not yet peer-reviewed, the idea has the potential to transform how scientists connect cell morphology with biological concepts.

    What You’ll Hear:

    • Cell Painting 101 — how high-content imaging creates “morphological fingerprints” of cells, and why these fingerprints are powerful but hard to interpret.
    • The CellCLIP idea — adapting the CLIP model from computer vision to align cell images with text descriptions like drug names, pathways, or gene knockouts.
    • Proof-of-concept results — retrieval tests, mechanism-of-action classification, and generalization across genetic and chemical perturbations.
    • Why it matters — from improving interpretability to enabling cross-modal integration of biology, and even accelerating drug discovery.
    • Open questions — how well CellCLIP handles unseen drugs, whether it learns biology vs. memorization, and how it will scale to massive datasets like JUMP-Cell Painting.

    Together, these insights highlight a shift toward bridging cell biology and natural language — creating tools that could help scientists move from abstract image features to intuitive, actionable biological concepts.

    Got an idea for a topic or guest you’d love to hear on Molecule Talk? We’d love to hear from you!
    Connect with us at our ScienceIRT Website or on LinkedIn: Araceli Biosciences.


    If you enjoyed this episode, don’t forget to subscribe, leave us a review, and share it with a colleague who’s just as passionate about shaping the future of biotech as you are!

    🔗 Explore & Connect

    • Science in Real Time Website: https://www.aracelibio.com/science-irt-podcast-biology-big-data/
    • Araceli Biosciences LinkedIn: https://www.linkedin.com/company/araceli-biosciences/
    • Twitter/X: @AraceliBio
    • Instagram: @ScienceIRT_AraceliBio
    • TikTok: @ScienceIRT_AraceliBio


    References:

    • Ramesh, B., Singh, A., Huang, Y., Thienpont, B., & Carpenter, A. E. (2025). CellCLIP: Learning perturbation effects in cell painting via text-guided contrastive learning. arXiv. https://arxiv.org/abs/2506.06290 (PREPRINT)
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    8 分
  • Funding Focus - August 2025: Pharma Bets, AI Raises, and Policy Shifts

    Funding Focus - August 2025: Pharma Bets, AI Raises, and Policy Shifts
    2025/09/09

    In this month’s Funding Focus, host Carli Reyes unpacks the deals, policies, and investments shaping the future of biotech and drug discovery. From billion-dollar pharma bets to government-backed strategies, we explore how capital is accelerating science on a global scale.

    What you'll hear:

    • Novo Nordisk’s $550M partnership with Replicate Bioscience to advance self-replicating RNA therapies.
    • The UK’s £1.12B industrial strategy to position Britain as Europe’s biotech hub by 2030.
    • Phenomic AI’s $20M Series A, fueling the convergence of imaging and AI in oncology drug discovery.
    • The bigger picture: how public and private funding are converging into a global biotech ecosystem.

    We'll also share behind-the-scenes context and a look ahead at September — from the next wave of AI-biotech partnerships to new government R&D packages that could reshape where startups take root.

    Got an idea for a topic or a guest you’d love to hear on Science in Real Time? We’d love to hear from you!

    Connect with us at our ScienceIRT Website or on LinkedIn: Araceli Biosciences.


    If you enjoyed this episode, don’t forget to subscribe, leave us a review, and share it with a colleague who’s just as passionate about shaping the future of biotech as you are!

    🔗 Explore & Connect

    • Science in Real Time Website: https://www.aracelibio.com/science-irt-podcast-biology-big-data/
    • Araceli Biosciences LinkedIn: https://www.linkedin.com/company/araceli-biosciences/
    • Twitter/X: @AraceliBio
    • Instagram: @ScienceIRT_AraceliBio
    • TikTok: @ScienceIRT_AraceliBio


    🔗 References:

    • Novo Nordisk & Replicate Bioscience partnership: https://www.reuters.com/business/healthcare-pharmaceuticals/novo-nordisk-seeks-new-obesity-diabetes-drugs-with-replicate-bioscience-2025-08-28/
    • UK Life Sciences Industrial Strategy: https://www.thetimes.co.uk/article/biotech-growths-missing-link-appetite-for-risk-09q8zt0qw
    • Phenomic AI $20M Series A: https://www.fiercebiotech.com/biotech/funding-roundup-phenomic-ai-20m-series-a
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    7 分
  • BioScopes - Predictive Biology: Organoids, AI, and the Next Era of Research

    BioScopes - Predictive Biology: Organoids, AI, and the Next Era of Research
    2025/08/28
    In this BioScope episode, host Carli Reyes takes you inside four groundbreaking stories that show how discovery science is evolving from proof-of-concept experiments to predictive, life-like models of human biology. From organoids that grow at the pace of a developing fetus to AI systems that simulate entire cells, this episode reveals how scientists are pushing past traditional limits and creating tools that make biology more realistic, scalable, and powerful.What You’ll Hear:Kidney organoids on a human timeline — the first fetal kidney models that grow step by step over nine months, opening new windows into birth defects, prenatal gene programs, and drug safety during pregnancy.“Minibrains” with a twist — immune cells called microglia aren’t just cleaning up, but actively building neural circuits, reshaping how we think about brain development and disorders.CellForge AI — a multi-agent AI that builds predictive “virtual cells” you can experiment on in silico, accelerating discovery while reducing reliance on costly lab experiments.Vascularized organoids — mini-hearts and mini-livers sprouting branching blood vessels, finally overcoming a major barrier in organoid research and bringing drug testing and personalized medicine closer to reality.Together, these stories highlight the convergence of stem cell science, high-content imaging, and AI — a new era where we don’t just observe biology, but predict and design it.Got an idea for a topic or a guest you’d love to hear on Science in Real Time? We’d love to hear from you! Connect with us at our ScienceIRT Website or on LinkedIn: Araceli Biosciences. If you enjoyed this episode, don’t forget to subscribe, leave us a review, and share it with a colleague who’s just as passionate about shaping the future of biotech as you are! 🔗 Explore & ConnectScience in Real Time Website: https://www.aracelibio.com/science-irt-podcast-biology-big-data/ Araceli Biosciences LinkedIn: https://www.linkedin.com/company/araceli-biosciences/Twitter/X: @AraceliBioInstagram: @ScienceIRT_AraceliBioTikTok: @ScienceIRT_AraceliBioReferences:Kidney OrganoidsNamestnikov, M., Cohen-Zontag, O., Omer, D., Gnatek, Y., Goldberg, S., Vincent, T., Singh, S., Shiber, Y., Yehudai, T. R., Volkov, H., Genet, D. F., Urbach, A., Polak-Charcon, S., Grinberg, I., Pode-Shakked, N., Weisz, B., Vaknin, Z., Freedman, B. S., & Dekel, B. (2025). Human fetal kidney organoids model early human nephrogenesis and Notch-driven cell fate. The EMBO Journal, 44(14), e00504. https://doi.org/10.1038/s44318-025-00504-2Reuters. (2025, August 20). Health Rounds: Human fetal kidney development mimicked in test tubes. Reuters. Retrieved from https://www.reuters.com/business/healthcare-pharmaceuticals/health-rounds-human‑fetal‑kidney‑development‑mimicked‑test‑tubes‑2025‑08‑20/Minibrains & MicrogliaYu, D., Jain, S., Wangzhou, A., Zhu, B., Shao, W., Coley-O’Rourke, E. J., De Florencio, S., Kim, J., Choi, J. J., Paredes, M. F., Nowakowski, T. J., Huang, E. J., & Piao, X. (2025, August 6). Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1. Nature. https://doi.org/10.1038/s41586-025-08958-5Lanese, N. (2025, August 24). 'Minibrains' reveal secrets of how key brain cells form in the womb. Live Science. https://www.livescience.com/health/neuroscience/minibrains-reveal-secrets-of-how-key-brain-cells-form-in-the-womb?utm_source=chatgpt.comCellForge AITang, X., Yu, Z., Chen, J., Cui, Y., Shao, D., Wang, W., Wu, F., Zhuang, Y., Shi, W., Huang, Z., Cohan, A., Lin, X., Theis, F., Krishnaswamy, S., & Gerstein, M. (2025, August 4). CellForge: Agentic design of virtual cell models. arXiv. https://doi.org/10.48550/arXiv.2508.02276 GitHub — CellForge code repository (https://github.com/gersteinlab/CellForge) Heart Organoids with VesselsAbilez, O. J., Yang, H., Guan, Y., Shen, M., Yildirim, Z., Zhuge, Y., Venkateshappa, R., Zhao, S. R., Gomez, A. H., El-Mokahal, M., Dunkenberger, L., Ono, Y., Shibata, M., Nwokoye, P. N., Tian, L., Wilson, K. D., Lyall, E. H., Jia, F., Wo, H. T., Zhou, G., Aldana, B., Karakikes, I., Obal, D., Peltz, G., Zarins, C. K., & Wu, J. C. (2025, June 5). Gastruloids enable modeling of the earliest stages of human cardiac and hepatic vascularization. Science, 388(6751), eadu9375. https://doi.org/10.1126/science.adu9375Bai, N. (2025, June 5). How a Stanford breakthrough in lab-grown mini-hearts could change medical research. San Francisco Chronicle. Retrieved from https://www.sfchronicle.com/science/article/heart-organoid-medicine-drug-discovery-research-20357811.php?utm_source=chatgpt.com
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    12 分
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