
"Promising Decline in U.S. Opioid Overdose Deaths Amid Ongoing Epidemic"
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Digging deeper, the most deadly substances have shifted over time. Since the late 1990s, opioid deaths have occurred in three waves: first, a prescription painkiller-driven wave, followed by heroin, and most recently, a sharp increase due to synthetic opioids like illicitly manufactured fentanyl. The recent decline in deaths is driven by fewer overdoses from several sources. For instance, CDC data reveals deaths involving heroin are down by about one-third, deaths from prescription opioids fell by nearly 12 percent, and fatalities linked to synthetic opioids like fentanyl—while still alarmingly high—saw a two percent decrease.
However, the picture is complex and not all regions or populations have experienced relief. Research published in JAMA Network Open in June 2025 found that while the countrywide death rate peaked in late summer of 2023 and began to drop, the pace of decline varied by region. The Northeast, Midwest, and South peaked earlier, while the West peaked a year later. In contrast to the overall decline, overdose death rates continued to rise, albeit more slowly, among older adults, Black or African American communities, American Indian or Alaska Native populations, and some multiracial and Hispanic groups.
The impact of opioids goes beyond loss of life. According to Drug Abuse Statistics, more than 2.3 million people abused opioids in an average month last year, translating to over 80,000 each day. Approximately 3.2 percent of American adults misused these drugs, and 75 percent of overdose deaths continue to involve opioids, the vast majority driven by fentanyl. Social costs have soared as well: opioid misuse is now estimated to cost the US $1.5 trillion annually in healthcare, lost productivity, and legal expenses.
The pattern repeats elsewhere. Canadian public health reports show
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