『Painkiller NSAIDs Boost Muscle Growth, Not Strength, in Trained Men』のカバーアート

Painkiller NSAIDs Boost Muscle Growth, Not Strength, in Trained Men

Painkiller NSAIDs Boost Muscle Growth, Not Strength, in Trained Men

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 This episode reviews a 2025 research article in "The Journal of Physiology," authored by Mallinson et al., which investigates the effects of Non-Steroidal Anti-Inflammatory Drug (NSAID) ingestion alongside resistance exercise training (RET) in trained men. The study, a randomized, placebo-controlled, double-blind experiment, found that daily consumption of diclofenac over 84 days augmented muscle hypertrophy (increased muscle cross-sectional area and volume) compared to a placebo, particularly between days 28 and 84 of training. Notably, this increased muscle size was not accompanied by greater gains in muscle strength or increased total workout output, suggesting the NSAID enhanced the molecular signals for muscle growth but did not translate to superior functional performance. The researchers observed that gene networks linked to muscle growth and metabolism were more profoundly altered in the NSAID group, indicating a differential effect on muscle mRNA expression. Despite the muscle size benefits, the authors conclude that recommending chronic NSAID use for enhancing sports performance is inadvisable due to the lack of strength improvement and known adverse effects, though it might aid muscle mass restoration after injury.
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