Opioid Overdose Deaths Decline in the U.S. for the First Time Since 2018, Offering Cautious Hope
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Three distinct waves have defined the opioid overdose epidemic since the 1990s. The first wave stemmed from increased opioid prescriptions, especially for pain management. The second wave saw a surge in heroin-related deaths starting in 2010, and the third wave began in 2013 with the proliferation of powerful synthetic opioids like fentanyl. Illegally manufactured fentanyl is now the leading cause of opioid deaths and is often mixed with other drugs, increasing the risk for unsuspecting users. From 2022 to 2023, deaths involving synthetic opioids other than methadone—mostly fentanyl—decreased by 2%, while heroin-involved deaths dropped by about 33% and prescription opioid deaths fell by nearly 12%, according to CDC data.
State-level differences reveal further complexity. For example, Ohio reported a 9% decrease in unintentional drug overdose deaths in 2023—double the national decrease—and the state’s Department of Health found that illicit fentanyl was involved in 78% of overdose deaths, often combined with other drugs. Similar decreases occurred in some Canadian provinces, with Canada reporting most opioid toxicity deaths in British Columbia, Alberta, and Ontario. Between January and March of 2025, Canada saw 1,377 apparent opioid toxicity deaths, 95% of which were accidental, according to the Public Health Agency of Canada. Of those, 63% involved fentanyl and 82% involved non-pharmaceutical opioids, indicating the overwhelming presence of street drugs rather than prescribed medications.
Though the U.S. witnessed improvement, the scope remains daunting. An estimated 8.9 million Americans aged 12 and up abused opioids in 2023, with 3.2%
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