Opioid Epidemic Shows Promising Signs of Decline in North America
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Listeners should know the crisis isn’t monolithic; it’s been marked by three main waves over the past quarter-century. The first began in the late 1990s with skyrocketing opioid prescriptions. By 2010, a second wave emerged, driven by a steep rise in heroin overdoses. Then, starting around 2013, a third and ongoing wave arrived with the proliferation of illegal, synthetic opioids—especially fentanyl and its analogs. These highly potent substances are often mixed into heroin, counterfeit pills, and even non-opioid drugs, amplifying both their potency and danger. The CDC highlights that from 2022 to 2023, overdose deaths involving synthetic opioids like fentanyl decreased slightly by two percent. Heroin-related deaths declined more precipitously, by about 33 percent, and prescription opioid deaths dropped nearly 12 percent. Still, the illegal drug supply remains highly unpredictable, with fentanyl frequently found in drugs where users may not expect it.
Polydrug use is now a defining feature of the epidemic. Nearly half of all overdose deaths in 2023 involved opioids in combination with stimulants such as cocaine or methamphetamine. The addition of substances like the animal tranquilizer xylazine—a non-opioid sedative now often detected in fentanyl supplies—has made overdose events even more complex and resistant to treatment.
This growing crisis is not unique to the United States. In Canada, the Public Health Agency reports over 53,800 apparent opioid toxicity deaths since national surveillance began in 2016. In the first three months of 2025 alone, Canada
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